Assessment of the Safety and Efficiency of a Preperitoneal Continuous Infusion Using Bupivacaine after Abdominal Laparotomy in Digestive Carcinology
The purpose of this paper is to evaluate the safety and efficacy of continuous preperitoneal wound infiltration using bupivacaine after abdominal laparotomy in relation to plasma bupivacaine concentration and visual analog scale. Our study was performed on 60 adult patients with digestive cancer, op...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-01-01
|
| Series: | Anesthesiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2023/8842393 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850173341403447296 |
|---|---|
| author | Hayat Ben-Saghroune Mohammed Abdessadek Sanae Achour Youssef Kfal Abderrahim El Bouazzaoui Nabil Kanjaa Hicham Sbai |
| author_facet | Hayat Ben-Saghroune Mohammed Abdessadek Sanae Achour Youssef Kfal Abderrahim El Bouazzaoui Nabil Kanjaa Hicham Sbai |
| author_sort | Hayat Ben-Saghroune |
| collection | DOAJ |
| description | The purpose of this paper is to evaluate the safety and efficacy of continuous preperitoneal wound infiltration using bupivacaine after abdominal laparotomy in relation to plasma bupivacaine concentration and visual analog scale. Our study was performed on 60 adult patients with digestive cancer, operated at laparotomy, and randomized into two groups: bupivacaine and saline groups. The wound infiltration was through a multiperforated catheter along the scar. For the bupivacaine group, 0.25% bupivacaine was used; however, for the saline group, only saline (0.9%) was infiltrated. The pain was assessed by using the visual analog scale (VAS) in both groups. Plasma bupivacaine concentration was measured by high-performance liquid chromatography. The bupivacaine group had significantly lower postoperative morphine consumption and lower postoperative pain than the saline group (P < 0.0001). The majority of patients in the bupivacaine group had significant relief with the VAS scores of less than 3/10 cm at rest and 6/10 cm on mobilization. However, for the saline group, the VAS scores were higher than 6/10 cm either at rest or with mobilization. There was no clinical sign of toxicity and no technical complications for the bupivacaine group. Only eleven patients required morphine in this group, but the majority of patients received morphine at different doses in the saline group. Plasma bupivacaine was at very low concentrations. Overall, the current study has confirmed that continuous preperitoneal wound infiltration as postoperative analgesia is a simple, effective, and safe technique. It allows decreasing of morphine consumption and subsequently canceling their side effects. |
| format | Article |
| id | doaj-art-d36f158cd91a4819a0ce6e53f9e1e144 |
| institution | OA Journals |
| issn | 1687-6970 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Anesthesiology Research and Practice |
| spelling | doaj-art-d36f158cd91a4819a0ce6e53f9e1e1442025-08-20T02:19:51ZengWileyAnesthesiology Research and Practice1687-69702023-01-01202310.1155/2023/8842393Assessment of the Safety and Efficiency of a Preperitoneal Continuous Infusion Using Bupivacaine after Abdominal Laparotomy in Digestive CarcinologyHayat Ben-Saghroune0Mohammed Abdessadek1Sanae Achour2Youssef Kfal3Abderrahim El Bouazzaoui4Nabil Kanjaa5Hicham Sbai6Laboratory of Anesthesia-Intensive Care and Emergency MedicineLaayoune Higher School of TechnologyFaculty of Medicine and PharmacyCentral Medical Analysis LaboratoryLaboratory of Anesthesia-Intensive Care and Emergency MedicineLaboratory of Anesthesia-Intensive Care and Emergency MedicineAnaesthesia and Critical Care DepartmentThe purpose of this paper is to evaluate the safety and efficacy of continuous preperitoneal wound infiltration using bupivacaine after abdominal laparotomy in relation to plasma bupivacaine concentration and visual analog scale. Our study was performed on 60 adult patients with digestive cancer, operated at laparotomy, and randomized into two groups: bupivacaine and saline groups. The wound infiltration was through a multiperforated catheter along the scar. For the bupivacaine group, 0.25% bupivacaine was used; however, for the saline group, only saline (0.9%) was infiltrated. The pain was assessed by using the visual analog scale (VAS) in both groups. Plasma bupivacaine concentration was measured by high-performance liquid chromatography. The bupivacaine group had significantly lower postoperative morphine consumption and lower postoperative pain than the saline group (P < 0.0001). The majority of patients in the bupivacaine group had significant relief with the VAS scores of less than 3/10 cm at rest and 6/10 cm on mobilization. However, for the saline group, the VAS scores were higher than 6/10 cm either at rest or with mobilization. There was no clinical sign of toxicity and no technical complications for the bupivacaine group. Only eleven patients required morphine in this group, but the majority of patients received morphine at different doses in the saline group. Plasma bupivacaine was at very low concentrations. Overall, the current study has confirmed that continuous preperitoneal wound infiltration as postoperative analgesia is a simple, effective, and safe technique. It allows decreasing of morphine consumption and subsequently canceling their side effects.http://dx.doi.org/10.1155/2023/8842393 |
| spellingShingle | Hayat Ben-Saghroune Mohammed Abdessadek Sanae Achour Youssef Kfal Abderrahim El Bouazzaoui Nabil Kanjaa Hicham Sbai Assessment of the Safety and Efficiency of a Preperitoneal Continuous Infusion Using Bupivacaine after Abdominal Laparotomy in Digestive Carcinology Anesthesiology Research and Practice |
| title | Assessment of the Safety and Efficiency of a Preperitoneal Continuous Infusion Using Bupivacaine after Abdominal Laparotomy in Digestive Carcinology |
| title_full | Assessment of the Safety and Efficiency of a Preperitoneal Continuous Infusion Using Bupivacaine after Abdominal Laparotomy in Digestive Carcinology |
| title_fullStr | Assessment of the Safety and Efficiency of a Preperitoneal Continuous Infusion Using Bupivacaine after Abdominal Laparotomy in Digestive Carcinology |
| title_full_unstemmed | Assessment of the Safety and Efficiency of a Preperitoneal Continuous Infusion Using Bupivacaine after Abdominal Laparotomy in Digestive Carcinology |
| title_short | Assessment of the Safety and Efficiency of a Preperitoneal Continuous Infusion Using Bupivacaine after Abdominal Laparotomy in Digestive Carcinology |
| title_sort | assessment of the safety and efficiency of a preperitoneal continuous infusion using bupivacaine after abdominal laparotomy in digestive carcinology |
| url | http://dx.doi.org/10.1155/2023/8842393 |
| work_keys_str_mv | AT hayatbensaghroune assessmentofthesafetyandefficiencyofapreperitonealcontinuousinfusionusingbupivacaineafterabdominallaparotomyindigestivecarcinology AT mohammedabdessadek assessmentofthesafetyandefficiencyofapreperitonealcontinuousinfusionusingbupivacaineafterabdominallaparotomyindigestivecarcinology AT sanaeachour assessmentofthesafetyandefficiencyofapreperitonealcontinuousinfusionusingbupivacaineafterabdominallaparotomyindigestivecarcinology AT youssefkfal assessmentofthesafetyandefficiencyofapreperitonealcontinuousinfusionusingbupivacaineafterabdominallaparotomyindigestivecarcinology AT abderrahimelbouazzaoui assessmentofthesafetyandefficiencyofapreperitonealcontinuousinfusionusingbupivacaineafterabdominallaparotomyindigestivecarcinology AT nabilkanjaa assessmentofthesafetyandefficiencyofapreperitonealcontinuousinfusionusingbupivacaineafterabdominallaparotomyindigestivecarcinology AT hichamsbai assessmentofthesafetyandefficiencyofapreperitonealcontinuousinfusionusingbupivacaineafterabdominallaparotomyindigestivecarcinology |