The role of lipid profile in the relationship between skipping breakfast and hyperuricemia: a moderated mediation model
Abstract Background The prevalence of hyperuricemia is rising among oilfield workers in China. This study aimed to explore the underlying mechanisms between skipping breakfast and serum uric acid. Methods A total of 21,676 participants aged 20-60 from a large oilfield company in China were included....
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BMC
2025-04-01
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| Online Access: | https://doi.org/10.1186/s12889-025-22594-7 |
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| author | Zhihao Deng Feixiang Zhou Gang Tian Qi Wang Yan Yan |
| author_facet | Zhihao Deng Feixiang Zhou Gang Tian Qi Wang Yan Yan |
| author_sort | Zhihao Deng |
| collection | DOAJ |
| description | Abstract Background The prevalence of hyperuricemia is rising among oilfield workers in China. This study aimed to explore the underlying mechanisms between skipping breakfast and serum uric acid. Methods A total of 21,676 participants aged 20-60 from a large oilfield company in China were included. Association analysis, multivariate logistic, subgroup analysis, and moderated mediation analysis were performed to assess the association between skipping breakfast and hyperuricemia. Results We found that 24.48% of oilfield employees had hyperuricemia. The odds ratio of hyperuricemia linked to skipping breakfast was 0.78 (95%CI: 0.69-0.88). The association between skipping breakfast and hyperuricemia was mediated by TC (22.32%) and LDL-C (21.57%). Age moderated this mediation, with significant effects for skipping breakfast (ß: 0.553, 95%CI: 0.042-1.063) and TC (ß: -0.339, 95%CI: -0.586- -0.093). Similar results were observed for LDL-C mediation (ß: 0.522, 95%CI: 0.009-1.035; ß: -0.585, 95%CI: -0.894- -0.276). Conclusion Skipping breakfast positively influenced hyperuricemia through TC and LDL-C. Age moderated the relationship between skipping breakfast and serum uric acid. Greater attention should be given to young employees in Chinese oilfield enterprises, with dietary interventions implemented to reduce abnormal lipids metabolism and hyperuricemia. |
| format | Article |
| id | doaj-art-d36ef55bf97443f894bcfdd17cb5633c |
| institution | OA Journals |
| issn | 1471-2458 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
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| series | BMC Public Health |
| spelling | doaj-art-d36ef55bf97443f894bcfdd17cb5633c2025-08-20T01:49:47ZengBMCBMC Public Health1471-24582025-04-0125111210.1186/s12889-025-22594-7The role of lipid profile in the relationship between skipping breakfast and hyperuricemia: a moderated mediation modelZhihao Deng0Feixiang Zhou1Gang Tian2Qi Wang3Yan Yan4Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South UniversityDepartment of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South UniversityHenan Province Hypertension Precision Prevention and Control Engineering Research Center, Henan Provincial People’s HospitalDepartment of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South UniversityDepartment of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South UniversityAbstract Background The prevalence of hyperuricemia is rising among oilfield workers in China. This study aimed to explore the underlying mechanisms between skipping breakfast and serum uric acid. Methods A total of 21,676 participants aged 20-60 from a large oilfield company in China were included. Association analysis, multivariate logistic, subgroup analysis, and moderated mediation analysis were performed to assess the association between skipping breakfast and hyperuricemia. Results We found that 24.48% of oilfield employees had hyperuricemia. The odds ratio of hyperuricemia linked to skipping breakfast was 0.78 (95%CI: 0.69-0.88). The association between skipping breakfast and hyperuricemia was mediated by TC (22.32%) and LDL-C (21.57%). Age moderated this mediation, with significant effects for skipping breakfast (ß: 0.553, 95%CI: 0.042-1.063) and TC (ß: -0.339, 95%CI: -0.586- -0.093). Similar results were observed for LDL-C mediation (ß: 0.522, 95%CI: 0.009-1.035; ß: -0.585, 95%CI: -0.894- -0.276). Conclusion Skipping breakfast positively influenced hyperuricemia through TC and LDL-C. Age moderated the relationship between skipping breakfast and serum uric acid. Greater attention should be given to young employees in Chinese oilfield enterprises, with dietary interventions implemented to reduce abnormal lipids metabolism and hyperuricemia.https://doi.org/10.1186/s12889-025-22594-7HyperuricemiaBreakfastLipid profileAgeWorking population |
| spellingShingle | Zhihao Deng Feixiang Zhou Gang Tian Qi Wang Yan Yan The role of lipid profile in the relationship between skipping breakfast and hyperuricemia: a moderated mediation model BMC Public Health Hyperuricemia Breakfast Lipid profile Age Working population |
| title | The role of lipid profile in the relationship between skipping breakfast and hyperuricemia: a moderated mediation model |
| title_full | The role of lipid profile in the relationship between skipping breakfast and hyperuricemia: a moderated mediation model |
| title_fullStr | The role of lipid profile in the relationship between skipping breakfast and hyperuricemia: a moderated mediation model |
| title_full_unstemmed | The role of lipid profile in the relationship between skipping breakfast and hyperuricemia: a moderated mediation model |
| title_short | The role of lipid profile in the relationship between skipping breakfast and hyperuricemia: a moderated mediation model |
| title_sort | role of lipid profile in the relationship between skipping breakfast and hyperuricemia a moderated mediation model |
| topic | Hyperuricemia Breakfast Lipid profile Age Working population |
| url | https://doi.org/10.1186/s12889-025-22594-7 |
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