Central IKKβ inhibition prevents air pollution mediated peripheral inflammation and exaggeration of type II diabetes

Central IKKβ inhibition prevents air pollution mediated peripheral inflammation and exaggeration of type II diabetes

Abstract Background Prior experimental and epidemiologic data support a link between exposure to fine ambient particulate matter (<2.5 μm in aerodynamic diameter, PM2.5) and development of insulin resistance/Type II diabetes mellitus (Type II DM). We investigated the role of hypothalamic inflamma...

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Main Authors: Cuiqing Liu, Laura K Fonken, Aixia Wang, Andrei Maiseyeu, Yuntao Bai, Tse-Yao Wang, Santosh Maurya, Yi-An Ko, Muthu Periasamy, Timothy Dvonch, Masako Morishita, Robert D Brook, Jack Harkema, Zhekang Ying, Bhramar Mukherjee, Qinghua Sun, Randy J Nelson, Sanjay Rajagopalan
Format: Article
Language:English
Published: BMC 2014-10-01
Series:Particle and Fibre Toxicology
Subjects:
Diabetes
Particulate matter
Hypothalamus
Inflammation
IKKβ
Online Access:https://doi.org/10.1186/s12989-014-0053-5
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