Two-dimensional graphene nanomaterials for combined photothermal and chemotherapy-enhanced targeted therapy of breast cancer
Breast cancer is one of the most common malignant tumors in women, accounting for 7–10 % of all malignant tumors in the body. Second only to uterine cancer, it poses a significant threat to women's health. In this study, a two-dimensional material based on GO nanoparticles was designed to combi...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006425002261 |
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| author | Xiongjie Zhu Juanjuan Lei Chao Jiang Zhaobi Fang Wenkai Zhang Zhe Yang Rui Guo Rui Xu Xiaoshan Hu |
| author_facet | Xiongjie Zhu Juanjuan Lei Chao Jiang Zhaobi Fang Wenkai Zhang Zhe Yang Rui Guo Rui Xu Xiaoshan Hu |
| author_sort | Xiongjie Zhu |
| collection | DOAJ |
| description | Breast cancer is one of the most common malignant tumors in women, accounting for 7–10 % of all malignant tumors in the body. Second only to uterine cancer, it poses a significant threat to women's health. In this study, a two-dimensional material based on GO nanoparticles was designed to combine photothermal therapy (PTT) with chemotherapy for targeted treatment of breast cancer. Firstly, HPAA was grafted onto GO through an amide reaction after EDC/NHS activation. Secondly, RGD was attached to the amino group of HPAA. Finally, the chemotherapeutic drug doxorubicin was loaded through intermolecular interactions. In vitro results showed that the HPAA/GO-RGD@DOX exhibited a good photothermal effect and drug release profile, with greater drug release in acidic environments compared to neutral ones. Additionally, it accelerated the apoptosis of tumor cells under laser irradiation. Importantly, in vivo experiments demonstrated that HPAA/GO-RGD@DOX, when combined with laser irradiation, effectively targeted the tumor site and inhibited tumor growth. In conclusion, HPAA/GO-RGD@DOX exhibits high tumor targeting efficiency and a strong photothermal effect. This study suggests that the HPAA/GO-RGD@DOX composite holds great promise as a new type of functional 2D nanoparticle with photothermal capabilities for breast cancer therapy. |
| format | Article |
| id | doaj-art-d36cc687e0524cbaa61e4b10149449b7 |
| institution | DOAJ |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-d36cc687e0524cbaa61e4b10149449b72025-08-20T02:59:46ZengElsevierMaterials Today Bio2590-00642025-06-013210166810.1016/j.mtbio.2025.101668Two-dimensional graphene nanomaterials for combined photothermal and chemotherapy-enhanced targeted therapy of breast cancerXiongjie Zhu0Juanjuan Lei1Chao Jiang2Zhaobi Fang3Wenkai Zhang4Zhe Yang5Rui Guo6Rui Xu7Xiaoshan Hu8Department of Medical Oncology, Guangzhou Institute of Cancer Research, The Affiliated Cancer Hospital, Guangzhou Medical University, Guangzhou, ChinaDepartment of Hepatobiliary Surgery, Guangzhou Institute of Cancer Research, The Affiliated Cancer Hospital, Guangzhou Medical University, Guangzhou, ChinaDepartment of Cancer Center, The People's Hospital of Baoan Shenzhen, Guangdong, ChinaDepartment of Oncology, Zhujiang Hospital of Southern Medical University, Guangzhou, ChinaDepartment of Medical Oncology, Guangzhou Institute of Cancer Research, The Affiliated Cancer Hospital, Guangzhou Medical University, Guangzhou, ChinaSouthern Medical University, Guangzhou, ChinaKey Laboratory of Biomaterials Of Guangdong Higher Education Institutes, Guangdong Provincial Engineering and Technological Research Centre for Drug Carrier Development, Department of Biomedical Engineering, Jinan University, Guangzhou, China; Corresponding author.Department of Medical Oncology, Guangzhou Institute of Cancer Research, The Affiliated Cancer Hospital, Guangzhou Medical University, Guangzhou, China; Corresponding author.Department of Medical Oncology, Guangzhou Institute of Cancer Research, The Affiliated Cancer Hospital, Guangzhou Medical University, Guangzhou, China; Corresponding author.Breast cancer is one of the most common malignant tumors in women, accounting for 7–10 % of all malignant tumors in the body. Second only to uterine cancer, it poses a significant threat to women's health. In this study, a two-dimensional material based on GO nanoparticles was designed to combine photothermal therapy (PTT) with chemotherapy for targeted treatment of breast cancer. Firstly, HPAA was grafted onto GO through an amide reaction after EDC/NHS activation. Secondly, RGD was attached to the amino group of HPAA. Finally, the chemotherapeutic drug doxorubicin was loaded through intermolecular interactions. In vitro results showed that the HPAA/GO-RGD@DOX exhibited a good photothermal effect and drug release profile, with greater drug release in acidic environments compared to neutral ones. Additionally, it accelerated the apoptosis of tumor cells under laser irradiation. Importantly, in vivo experiments demonstrated that HPAA/GO-RGD@DOX, when combined with laser irradiation, effectively targeted the tumor site and inhibited tumor growth. In conclusion, HPAA/GO-RGD@DOX exhibits high tumor targeting efficiency and a strong photothermal effect. This study suggests that the HPAA/GO-RGD@DOX composite holds great promise as a new type of functional 2D nanoparticle with photothermal capabilities for breast cancer therapy.http://www.sciencedirect.com/science/article/pii/S2590006425002261Two-dimensionalPhotothermal therapyChemotherapyTargetedBreast cancer |
| spellingShingle | Xiongjie Zhu Juanjuan Lei Chao Jiang Zhaobi Fang Wenkai Zhang Zhe Yang Rui Guo Rui Xu Xiaoshan Hu Two-dimensional graphene nanomaterials for combined photothermal and chemotherapy-enhanced targeted therapy of breast cancer Materials Today Bio Two-dimensional Photothermal therapy Chemotherapy Targeted Breast cancer |
| title | Two-dimensional graphene nanomaterials for combined photothermal and chemotherapy-enhanced targeted therapy of breast cancer |
| title_full | Two-dimensional graphene nanomaterials for combined photothermal and chemotherapy-enhanced targeted therapy of breast cancer |
| title_fullStr | Two-dimensional graphene nanomaterials for combined photothermal and chemotherapy-enhanced targeted therapy of breast cancer |
| title_full_unstemmed | Two-dimensional graphene nanomaterials for combined photothermal and chemotherapy-enhanced targeted therapy of breast cancer |
| title_short | Two-dimensional graphene nanomaterials for combined photothermal and chemotherapy-enhanced targeted therapy of breast cancer |
| title_sort | two dimensional graphene nanomaterials for combined photothermal and chemotherapy enhanced targeted therapy of breast cancer |
| topic | Two-dimensional Photothermal therapy Chemotherapy Targeted Breast cancer |
| url | http://www.sciencedirect.com/science/article/pii/S2590006425002261 |
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