Unravelling the transcriptome of the human tuberculosis lesion and its clinical implications

Unravelling the transcriptome of the human tuberculosis lesion and its clinical implications

Abstract The tuberculosis (TB) lesion is a complex structure, contributing to the overall spectrum of TB. We characterise, using RNA sequencing, 44 fresh human pulmonary TB lesion samples from 13 TB individuals (drug-sensitive and multidrug-resistant TB) undergoing therapeutic surgery. We confirm cl...

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Main Authors: Kaori L. Fonseca, Juan José Lozano, Albert Despuig, Dominic Habgood-Coote, Julia Sidorova, Diego Aznar, Lilibeth Arias, Álvaro Del Río-Álvarez, Juan Carrillo-Reixach, Aaron Goff, Leticia Muraro Wildner, Shota Gogishvili, Keti Nikolaishvili, Natalia Shubladze, Zaza Avaliani, Gustavo Tapia, Paula Rodríguez-Martínez, Pere-Joan Cardona, Federico Martinón-Torres, Antonio Salas, Alberto Gómez-Carballa, Carolina Armengol, Simon J. Waddell, Myrsini Kaforou, Anne O’Garra, Sergo Vashakidze, Cristina Vilaplana
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60255-w
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