Association between surgery and increased survival in primary central nervous system lymphoma: a retrospective cohort study
Abstract This study investigated the effect of surgery on the prognosis of patients with primary central nervous system lymphoma (PCNSL) using data from the surveillance, epidemiology, and end results (SEER) database. A cohort of 5932 patients was analyzed, with 1466 undergoing surgical intervention...
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Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-025-88351-3 |
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| author | Gangping Li XinJiang Hou Yuewen Fu DongJie He Di Zhang |
| author_facet | Gangping Li XinJiang Hou Yuewen Fu DongJie He Di Zhang |
| author_sort | Gangping Li |
| collection | DOAJ |
| description | Abstract This study investigated the effect of surgery on the prognosis of patients with primary central nervous system lymphoma (PCNSL) using data from the surveillance, epidemiology, and end results (SEER) database. A cohort of 5932 patients was analyzed, with 1466 undergoing surgical intervention (780 subtotal resection (STR), 686 gross total resection (GTR)) and 4466 receiving no surgery or biopsy only. The median age of the study population was 61.5 years. The median survival was 24.0 months for STR, 30.0 months for GTR, and 18.0 months for non-surgical patients (P < 0.001). Multivariate Cox regression analyses showed that the adjusted hazard ratio (HR) for STR was 0.77 (95% CI 0.70–0.85, P < 0.001) for overall survival (OS) and 0.74 (95% CI 0.66–0.83, P < 0.001) for cancer-specific survival (CSS). For GTR, the adjusted HR was 0.73 (95% CI 0.65–0.80, P < 0.001) for OS and 0.73 (95% CI 0.65–0.82, P < 0.001) for CSS. These results remained robust even after subgroup analyses, sensitivity analyses and propensity score matching (PSM). No significant interactions were observed in any subgroup. These findings indicate that surgery may improve the survival of patients with PCNSL, though further research is needed to confirm these findings. A key limitation is the inability to stratify patients by performance status and lesion number, critical for assessing resective surgery suitability. |
| format | Article |
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| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
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| spelling | doaj-art-d3695ed2126349ec8fd36bfa964415842025-02-02T12:23:02ZengNature PortfolioScientific Reports2045-23222025-01-0115111110.1038/s41598-025-88351-3Association between surgery and increased survival in primary central nervous system lymphoma: a retrospective cohort studyGangping Li0XinJiang Hou1Yuewen Fu2DongJie He3Di Zhang4Department of Hematology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer HospitalCollege of Medicine, Xi’an International UniversityDepartment of Hematology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer HospitalDepartment of Radiation Oncology, Tangdu Hospital, Second Affiliated Hospital of Air Force Military Medical UniversityDepartment of Medical Records Management, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer HospitalAbstract This study investigated the effect of surgery on the prognosis of patients with primary central nervous system lymphoma (PCNSL) using data from the surveillance, epidemiology, and end results (SEER) database. A cohort of 5932 patients was analyzed, with 1466 undergoing surgical intervention (780 subtotal resection (STR), 686 gross total resection (GTR)) and 4466 receiving no surgery or biopsy only. The median age of the study population was 61.5 years. The median survival was 24.0 months for STR, 30.0 months for GTR, and 18.0 months for non-surgical patients (P < 0.001). Multivariate Cox regression analyses showed that the adjusted hazard ratio (HR) for STR was 0.77 (95% CI 0.70–0.85, P < 0.001) for overall survival (OS) and 0.74 (95% CI 0.66–0.83, P < 0.001) for cancer-specific survival (CSS). For GTR, the adjusted HR was 0.73 (95% CI 0.65–0.80, P < 0.001) for OS and 0.73 (95% CI 0.65–0.82, P < 0.001) for CSS. These results remained robust even after subgroup analyses, sensitivity analyses and propensity score matching (PSM). No significant interactions were observed in any subgroup. These findings indicate that surgery may improve the survival of patients with PCNSL, though further research is needed to confirm these findings. A key limitation is the inability to stratify patients by performance status and lesion number, critical for assessing resective surgery suitability.https://doi.org/10.1038/s41598-025-88351-3SurgeryCentral nervous systemLymphomaPrognosisSEER |
| spellingShingle | Gangping Li XinJiang Hou Yuewen Fu DongJie He Di Zhang Association between surgery and increased survival in primary central nervous system lymphoma: a retrospective cohort study Scientific Reports Surgery Central nervous system Lymphoma Prognosis SEER |
| title | Association between surgery and increased survival in primary central nervous system lymphoma: a retrospective cohort study |
| title_full | Association between surgery and increased survival in primary central nervous system lymphoma: a retrospective cohort study |
| title_fullStr | Association between surgery and increased survival in primary central nervous system lymphoma: a retrospective cohort study |
| title_full_unstemmed | Association between surgery and increased survival in primary central nervous system lymphoma: a retrospective cohort study |
| title_short | Association between surgery and increased survival in primary central nervous system lymphoma: a retrospective cohort study |
| title_sort | association between surgery and increased survival in primary central nervous system lymphoma a retrospective cohort study |
| topic | Surgery Central nervous system Lymphoma Prognosis SEER |
| url | https://doi.org/10.1038/s41598-025-88351-3 |
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