4D structural biology–quantitative dynamics in the eukaryotic RNA exosome complex

Abstract Molecular machines play pivotal roles in all biological processes. Most structural methods, however, are unable to directly probe molecular motions. Here, we demonstrate that dedicated NMR experiments can provide quantitative insights into functionally important dynamic regions in very larg...

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Bibliographic Details
Main Authors: Jobst Liebau, Daniela Lazzaretti, Torben Fürtges, Anna Bichler, Michael Pilsl, Till Rudack, Remco Sprangers
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62982-6
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