Neurostimulation on lumbosacral nerves as a new treatment for spinal cord injury impairments and its impact on cortical activity: a narrative review
Spinal cord injury (SCI) can cause significant motor, sensory, and autonomic dysfunction by disrupting neural connections. As a result, it is a global health challenge that requires innovative interventions to improve outcomes. This review assesses the wide-ranging impacts of SCI and focuses on the...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnhum.2024.1478423/full |
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| author | Rodrigo Lantyer Marques Dantas Diego N. Vilela Mariana Cardoso Melo Gustavo Fernandes Gustavo Fernandes Gustavo Fernandes Nucelio Lemos Nucelio Lemos Nucelio Lemos Jean Faber Jean Faber |
| author_facet | Rodrigo Lantyer Marques Dantas Diego N. Vilela Mariana Cardoso Melo Gustavo Fernandes Gustavo Fernandes Gustavo Fernandes Nucelio Lemos Nucelio Lemos Nucelio Lemos Jean Faber Jean Faber |
| author_sort | Rodrigo Lantyer Marques Dantas |
| collection | DOAJ |
| description | Spinal cord injury (SCI) can cause significant motor, sensory, and autonomic dysfunction by disrupting neural connections. As a result, it is a global health challenge that requires innovative interventions to improve outcomes. This review assesses the wide-ranging impacts of SCI and focuses on the laparoscopic implantation of neuroprosthesis (LION) as an emerging and promising rehabilitation technique. The LION technique involves the surgical implantation of electrodes on lumbosacral nerves to stimulate paralyzed muscles. Recent findings have demonstrated significant improvements in mobility, sexual function, and bladder/bowel control in chronic SCI patients following LION therapy. This manuscript revisits the potential physiological mechanisms underlying these results, including neuroplasticity and modulation of autonomic activity. Additionally, we discuss potential future applications and amendments of LION therapy. This study emphasizes the potential of neuromodulation as a complementary approach to traditional rehabilitation, that can provide a beacon of hope for improving functionality and quality of life for individuals with SCI. |
| format | Article |
| id | doaj-art-d367ec4ff4804eb2824ce5fbed38f7d8 |
| institution | DOAJ |
| issn | 1662-5161 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj-art-d367ec4ff4804eb2824ce5fbed38f7d82025-08-20T02:49:52ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612024-12-011810.3389/fnhum.2024.14784231478423Neurostimulation on lumbosacral nerves as a new treatment for spinal cord injury impairments and its impact on cortical activity: a narrative reviewRodrigo Lantyer Marques Dantas0Diego N. Vilela1Mariana Cardoso Melo2Gustavo Fernandes3Gustavo Fernandes4Gustavo Fernandes5Nucelio Lemos6Nucelio Lemos7Nucelio Lemos8Jean Faber9Jean Faber10Neuroscience Division, Department of Neurology and Neurosurgery, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, BrazilNeuroscience Division, Department of Neurology and Neurosurgery, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, BrazilBiomedical Engineering Division, Institute of Science and Technology, Federal University of São Paulo, São José dos Campos, BrazilDepartment of Gynecology, Federal University of São Paulo, São Paulo, BrazilDepartment of Gynecology and Neuropelveology, Increasing-Institute of Care and Rehabilitation in Neuropelveology and Gynecology, São Paulo, BrazilDepartment of Obstetrics and Gynecology, Santa Casa de São Paulo School of Medical Sciences, São Paulo, BrazilDepartment of Gynecology, Federal University of São Paulo, São Paulo, BrazilDepartment of Gynecology and Neuropelveology, Increasing-Institute of Care and Rehabilitation in Neuropelveology and Gynecology, São Paulo, BrazilDepartment of Obstetrics and Gynecology, Faculty of Medicine, University of Toronto, Toronto, ON, CanadaNeuroscience Division, Department of Neurology and Neurosurgery, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, BrazilBiomedical Engineering Division, Institute of Science and Technology, Federal University of São Paulo, São José dos Campos, BrazilSpinal cord injury (SCI) can cause significant motor, sensory, and autonomic dysfunction by disrupting neural connections. As a result, it is a global health challenge that requires innovative interventions to improve outcomes. This review assesses the wide-ranging impacts of SCI and focuses on the laparoscopic implantation of neuroprosthesis (LION) as an emerging and promising rehabilitation technique. The LION technique involves the surgical implantation of electrodes on lumbosacral nerves to stimulate paralyzed muscles. Recent findings have demonstrated significant improvements in mobility, sexual function, and bladder/bowel control in chronic SCI patients following LION therapy. This manuscript revisits the potential physiological mechanisms underlying these results, including neuroplasticity and modulation of autonomic activity. Additionally, we discuss potential future applications and amendments of LION therapy. This study emphasizes the potential of neuromodulation as a complementary approach to traditional rehabilitation, that can provide a beacon of hope for improving functionality and quality of life for individuals with SCI.https://www.frontiersin.org/articles/10.3389/fnhum.2024.1478423/fullneuromodulationspinal cord injurylaparoscopic neuroprosthesissensorimotor rehabilitationneural stimulation |
| spellingShingle | Rodrigo Lantyer Marques Dantas Diego N. Vilela Mariana Cardoso Melo Gustavo Fernandes Gustavo Fernandes Gustavo Fernandes Nucelio Lemos Nucelio Lemos Nucelio Lemos Jean Faber Jean Faber Neurostimulation on lumbosacral nerves as a new treatment for spinal cord injury impairments and its impact on cortical activity: a narrative review Frontiers in Human Neuroscience neuromodulation spinal cord injury laparoscopic neuroprosthesis sensorimotor rehabilitation neural stimulation |
| title | Neurostimulation on lumbosacral nerves as a new treatment for spinal cord injury impairments and its impact on cortical activity: a narrative review |
| title_full | Neurostimulation on lumbosacral nerves as a new treatment for spinal cord injury impairments and its impact on cortical activity: a narrative review |
| title_fullStr | Neurostimulation on lumbosacral nerves as a new treatment for spinal cord injury impairments and its impact on cortical activity: a narrative review |
| title_full_unstemmed | Neurostimulation on lumbosacral nerves as a new treatment for spinal cord injury impairments and its impact on cortical activity: a narrative review |
| title_short | Neurostimulation on lumbosacral nerves as a new treatment for spinal cord injury impairments and its impact on cortical activity: a narrative review |
| title_sort | neurostimulation on lumbosacral nerves as a new treatment for spinal cord injury impairments and its impact on cortical activity a narrative review |
| topic | neuromodulation spinal cord injury laparoscopic neuroprosthesis sensorimotor rehabilitation neural stimulation |
| url | https://www.frontiersin.org/articles/10.3389/fnhum.2024.1478423/full |
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