mGem: Decoding transmicrobe messaging—the growing impact of extracellular vesicles
ABSTRACT Extracellular vesicles (EVs) are membrane-enclosed nanoparticles that contain proteins, lipids, and nucleic acids, playing key roles in interactions between pathogens and hosts. Most research on pathogen-derived EVs has focused on understanding their impact on disease pathogenesis, immunomo...
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| Language: | English |
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American Society for Microbiology
2025-06-01
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| Series: | mBio |
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| Online Access: | https://journals.asm.org/doi/10.1128/mbio.03130-24 |
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| author | Alicia Rojas |
| author_facet | Alicia Rojas |
| author_sort | Alicia Rojas |
| collection | DOAJ |
| description | ABSTRACT Extracellular vesicles (EVs) are membrane-enclosed nanoparticles that contain proteins, lipids, and nucleic acids, playing key roles in interactions between pathogens and hosts. Most research on pathogen-derived EVs has focused on understanding their impact on disease pathogenesis, immunomodulation, and their use as biomarkers for diagnosis. However, few studies have explored the cross talk between bacteria, fungi, protozoa, helminths, or arthropods via EVs. This is particularly relevant in the human gut microenvironment, where a high diversity of microbes exists and is modulated with helminth gastrointestinal infections. Additionally, during blood-borne coinfections like malaria and lymphatic filariasis, direct communication between pathogens may take place, and in the arthropod-pathogen interface, the multiplication of some protozoa or helminths is essential for their development. Understanding transmicrobe EV communication may reveal novel therapeutic strategies for controlling infectious diseases in both vertebrate and invertebrate hosts, particularly in regions with high coinfection rates. |
| format | Article |
| id | doaj-art-d36645ea3f7945d790c1e44e366e4b1a |
| institution | OA Journals |
| issn | 2150-7511 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | American Society for Microbiology |
| record_format | Article |
| series | mBio |
| spelling | doaj-art-d36645ea3f7945d790c1e44e366e4b1a2025-08-20T02:33:00ZengAmerican Society for MicrobiologymBio2150-75112025-06-0116610.1128/mbio.03130-24mGem: Decoding transmicrobe messaging—the growing impact of extracellular vesiclesAlicia Rojas0Laboratory of Helminthology, Faculty of Microbiology, University of Costa Rica, San José, Costa RicaABSTRACT Extracellular vesicles (EVs) are membrane-enclosed nanoparticles that contain proteins, lipids, and nucleic acids, playing key roles in interactions between pathogens and hosts. Most research on pathogen-derived EVs has focused on understanding their impact on disease pathogenesis, immunomodulation, and their use as biomarkers for diagnosis. However, few studies have explored the cross talk between bacteria, fungi, protozoa, helminths, or arthropods via EVs. This is particularly relevant in the human gut microenvironment, where a high diversity of microbes exists and is modulated with helminth gastrointestinal infections. Additionally, during blood-borne coinfections like malaria and lymphatic filariasis, direct communication between pathogens may take place, and in the arthropod-pathogen interface, the multiplication of some protozoa or helminths is essential for their development. Understanding transmicrobe EV communication may reveal novel therapeutic strategies for controlling infectious diseases in both vertebrate and invertebrate hosts, particularly in regions with high coinfection rates.https://journals.asm.org/doi/10.1128/mbio.03130-24EVscoinfectionbacteriafungiprotozoahelminth |
| spellingShingle | Alicia Rojas mGem: Decoding transmicrobe messaging—the growing impact of extracellular vesicles mBio EVs coinfection bacteria fungi protozoa helminth |
| title | mGem: Decoding transmicrobe messaging—the growing impact of extracellular vesicles |
| title_full | mGem: Decoding transmicrobe messaging—the growing impact of extracellular vesicles |
| title_fullStr | mGem: Decoding transmicrobe messaging—the growing impact of extracellular vesicles |
| title_full_unstemmed | mGem: Decoding transmicrobe messaging—the growing impact of extracellular vesicles |
| title_short | mGem: Decoding transmicrobe messaging—the growing impact of extracellular vesicles |
| title_sort | mgem decoding transmicrobe messaging the growing impact of extracellular vesicles |
| topic | EVs coinfection bacteria fungi protozoa helminth |
| url | https://journals.asm.org/doi/10.1128/mbio.03130-24 |
| work_keys_str_mv | AT aliciarojas mgemdecodingtransmicrobemessagingthegrowingimpactofextracellularvesicles |