Individual differences in prelimbic neural representation of food and cocaine seeking
Summary: The prelimbic cortex is involved in operant reward seeking. However, the precise nature of its activity patterns and whether/how they differ between different types of rewards are largely unknown. We use miniscope calcium imaging to observe prelimbic activity during both food and cocaine se...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Cell Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124724013731 |
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| author | Joseph T. Glanzberg Alexander J. Denman Nicholas J. Beacher Matthew C. Broomer Bo Liang Yun Li Yavin Shaham Giovanni Barbera Yan Zhang Da-Ting Lin |
| author_facet | Joseph T. Glanzberg Alexander J. Denman Nicholas J. Beacher Matthew C. Broomer Bo Liang Yun Li Yavin Shaham Giovanni Barbera Yan Zhang Da-Ting Lin |
| author_sort | Joseph T. Glanzberg |
| collection | DOAJ |
| description | Summary: The prelimbic cortex is involved in operant reward seeking. However, the precise nature of its activity patterns and whether/how they differ between different types of rewards are largely unknown. We use miniscope calcium imaging to observe prelimbic activity during both food and cocaine seeking in freely behaving mice. We find that neurobehavioral representations remain stable across days within individual mice. Unexpectedly, our data reveal significant individual differences: some mice display high similarity in their prelimbic cortex activity patterns for both food and cocaine seeking, while others show no such overlap. These findings suggest that individual differences in the neural mechanisms underlying food and cocaine seeking could be a critical factor to consider when developing future addiction treatment strategies. |
| format | Article |
| id | doaj-art-d3647dd32988476a8a2899e9d6230d9c |
| institution | Kabale University |
| issn | 2211-1247 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj-art-d3647dd32988476a8a2899e9d6230d9c2024-11-29T06:23:36ZengElsevierCell Reports2211-12472024-12-014312115022Individual differences in prelimbic neural representation of food and cocaine seekingJoseph T. Glanzberg0Alexander J. Denman1Nicholas J. Beacher2Matthew C. Broomer3Bo Liang4Yun Li5Yavin Shaham6Giovanni Barbera7Yan Zhang8Da-Ting Lin9Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 333 Cassell Drive, Baltimore, MD 21224, USAIntramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 333 Cassell Drive, Baltimore, MD 21224, USAIntramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 333 Cassell Drive, Baltimore, MD 21224, USAIntramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 333 Cassell Drive, Baltimore, MD 21224, USASchool of Electrical Engineering & Computer Science, College of Engineering & Mines, University of North Dakota, 243 Centennial Drive Stop 7165, Grand Forks, ND 58202, USADepartment of Zoology and Physiology, University of Wyoming, 1000 E. University Avenue, Laramie, WY 82071, USAIntramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 333 Cassell Drive, Baltimore, MD 21224, USAIntramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 333 Cassell Drive, Baltimore, MD 21224, USANational Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence, Peking University, Beijing 100191, China; Corresponding authorIntramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 333 Cassell Drive, Baltimore, MD 21224, USA; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, MD 21205, USA; Corresponding authorSummary: The prelimbic cortex is involved in operant reward seeking. However, the precise nature of its activity patterns and whether/how they differ between different types of rewards are largely unknown. We use miniscope calcium imaging to observe prelimbic activity during both food and cocaine seeking in freely behaving mice. We find that neurobehavioral representations remain stable across days within individual mice. Unexpectedly, our data reveal significant individual differences: some mice display high similarity in their prelimbic cortex activity patterns for both food and cocaine seeking, while others show no such overlap. These findings suggest that individual differences in the neural mechanisms underlying food and cocaine seeking could be a critical factor to consider when developing future addiction treatment strategies.http://www.sciencedirect.com/science/article/pii/S2211124724013731CP: Neuroscience |
| spellingShingle | Joseph T. Glanzberg Alexander J. Denman Nicholas J. Beacher Matthew C. Broomer Bo Liang Yun Li Yavin Shaham Giovanni Barbera Yan Zhang Da-Ting Lin Individual differences in prelimbic neural representation of food and cocaine seeking Cell Reports CP: Neuroscience |
| title | Individual differences in prelimbic neural representation of food and cocaine seeking |
| title_full | Individual differences in prelimbic neural representation of food and cocaine seeking |
| title_fullStr | Individual differences in prelimbic neural representation of food and cocaine seeking |
| title_full_unstemmed | Individual differences in prelimbic neural representation of food and cocaine seeking |
| title_short | Individual differences in prelimbic neural representation of food and cocaine seeking |
| title_sort | individual differences in prelimbic neural representation of food and cocaine seeking |
| topic | CP: Neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2211124724013731 |
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