A Prospective Study on Complement Activation Distinguishes Focal Segmental Glomerulosclerosis from Minimal Change Disease

A Prospective Study on Complement Activation Distinguishes Focal Segmental Glomerulosclerosis from Minimal Change Disease

Introduction: Minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS) are related podocytopathies with distinct kidney outcomes. Surprisingly, elevated urinary activation fragments have been found in FSGS despite little complement deposition on immunofluorescence (IF) staining. Wh...

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Main Authors: Alexandra Cambier, Natacha Patey, Virginie Royal, François Gougeon, Dominique S. Genest, Soumeya Brachemi, Guillaume Bollée, Clémence Merlen, Arnaud Bonnefoy, Anne-Laure Lapeyraque, Stéphan Troyanov
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Kidney International Reports
Subjects:
complement activation
focal segmental glomerulosclerosis
minimal change disease
nephrotic syndrome
proteinuria
urinary complement fragments
Online Access:http://www.sciencedirect.com/science/article/pii/S2468024923016376
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