Single-cell signaling network profiling during redox stress reveals dynamic redox regulation in immune cells

Single-cell signaling network profiling during redox stress reveals dynamic redox regulation in immune cells

Abstract In eukaryotic cells, reactive oxygen species (ROS) serve as crucial signaling components. ROS are potentially toxic, so constant adjustments are needed to maintain cellular health. Here we describe a single-cell, mass cytometry-based method that we call signaling network under redox stress...

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Main Authors: Yi-Chuan Wang, Ping-Hsun Wu, Wen-Chieh Ting, Yi-Fu Wang, Ming-Han Yang, Tung-Hung Su, Jia-Ying Su, Hsun-I Sun, Wei-Min Huang, Pei-Ling Tsai, Gerlinde Wernig, Ping-Chih Ho, Limei Wang, Chen-Tu Wu, Yih-Leong Chang, Tseng-Cheng Chen, Tzu-Ching Meng, Yao-Ming Chang, Shih-Lei Lai, Chia-Wei Li, Tai-Ming Ko, Kai-Chien Yang, Ya-Jen Chang, Yijuang Chern, Mei-Chuan Kuo, Yen-Tsung Huang, Yi-Shiuan Tzeng, Jih-Luh Tang, Shih-Yu Chen
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60727-z
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