Receptor Binding Properties of Neuraminidase for influenza A virus: An Overview of Recent Research Advances
Influenza A viruses (IAVs) pose a serious risk to both human and animal health. IAVs’ receptor binding characteristics account for a major portion of their host range and tissue tropism. While the function of neuraminidase (NA) in promoting the release of progeny virus is well-known, its role in the...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2023-12-01
|
| Series: | Virulence |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/21505594.2023.2235459 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850108429212844032 |
|---|---|
| author | Lian Liu Gaojie Chen Shujian Huang Feng Wen |
| author_facet | Lian Liu Gaojie Chen Shujian Huang Feng Wen |
| author_sort | Lian Liu |
| collection | DOAJ |
| description | Influenza A viruses (IAVs) pose a serious risk to both human and animal health. IAVs’ receptor binding characteristics account for a major portion of their host range and tissue tropism. While the function of neuraminidase (NA) in promoting the release of progeny virus is well-known, its role in the virus entry process remains poorly understood. Studies have suggested that certain subtypes of NA can act as receptor-binding proteins, either alone or in conjunction with haemagglutinin (HA). An important distinction is that NA from the avian influenza virus have a second sialic acid-binding site (2SBS) that is preserved in avian strains but missing in human or swine strains. Those observations suggest that the 2SBS may play a key role in the adaptation of the avian influenza virus to mammalian hosts. In this review, we provide an update of the recent research advances in the receptor-binding role of NA and highlight its underestimated importance during the early stages of the IAV life cycle. By doing so, we aim to provide new insights into the mechanisms underlying IAV host adaptation and pathogenesis. |
| format | Article |
| id | doaj-art-d35a3f4cdc044a3bbab9c505dfd1b787 |
| institution | OA Journals |
| issn | 2150-5594 2150-5608 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Virulence |
| spelling | doaj-art-d35a3f4cdc044a3bbab9c505dfd1b7872025-08-20T02:38:22ZengTaylor & Francis GroupVirulence2150-55942150-56082023-12-0114110.1080/21505594.2023.2235459Receptor Binding Properties of Neuraminidase for influenza A virus: An Overview of Recent Research AdvancesLian Liu0Gaojie Chen1Shujian Huang2Feng Wen3Foshan University, Foshan, ChinaSchool of Life Science and Engineering, Foshan University, Foshan, ChinaSchool of Life Science and Engineering, Foshan University, Foshan, ChinaSchool of Life Science and Engineering, Foshan University, Foshan, ChinaInfluenza A viruses (IAVs) pose a serious risk to both human and animal health. IAVs’ receptor binding characteristics account for a major portion of their host range and tissue tropism. While the function of neuraminidase (NA) in promoting the release of progeny virus is well-known, its role in the virus entry process remains poorly understood. Studies have suggested that certain subtypes of NA can act as receptor-binding proteins, either alone or in conjunction with haemagglutinin (HA). An important distinction is that NA from the avian influenza virus have a second sialic acid-binding site (2SBS) that is preserved in avian strains but missing in human or swine strains. Those observations suggest that the 2SBS may play a key role in the adaptation of the avian influenza virus to mammalian hosts. In this review, we provide an update of the recent research advances in the receptor-binding role of NA and highlight its underestimated importance during the early stages of the IAV life cycle. By doing so, we aim to provide new insights into the mechanisms underlying IAV host adaptation and pathogenesis.https://www.tandfonline.com/doi/10.1080/21505594.2023.2235459Neuraminidaseinfluenza a virusavian influenza virussecond sialic acid-binding sitehost adaptationinterspecies transmission |
| spellingShingle | Lian Liu Gaojie Chen Shujian Huang Feng Wen Receptor Binding Properties of Neuraminidase for influenza A virus: An Overview of Recent Research Advances Virulence Neuraminidase influenza a virus avian influenza virus second sialic acid-binding site host adaptation interspecies transmission |
| title | Receptor Binding Properties of Neuraminidase for influenza A virus: An Overview of Recent Research Advances |
| title_full | Receptor Binding Properties of Neuraminidase for influenza A virus: An Overview of Recent Research Advances |
| title_fullStr | Receptor Binding Properties of Neuraminidase for influenza A virus: An Overview of Recent Research Advances |
| title_full_unstemmed | Receptor Binding Properties of Neuraminidase for influenza A virus: An Overview of Recent Research Advances |
| title_short | Receptor Binding Properties of Neuraminidase for influenza A virus: An Overview of Recent Research Advances |
| title_sort | receptor binding properties of neuraminidase for influenza a virus an overview of recent research advances |
| topic | Neuraminidase influenza a virus avian influenza virus second sialic acid-binding site host adaptation interspecies transmission |
| url | https://www.tandfonline.com/doi/10.1080/21505594.2023.2235459 |
| work_keys_str_mv | AT lianliu receptorbindingpropertiesofneuraminidaseforinfluenzaavirusanoverviewofrecentresearchadvances AT gaojiechen receptorbindingpropertiesofneuraminidaseforinfluenzaavirusanoverviewofrecentresearchadvances AT shujianhuang receptorbindingpropertiesofneuraminidaseforinfluenzaavirusanoverviewofrecentresearchadvances AT fengwen receptorbindingpropertiesofneuraminidaseforinfluenzaavirusanoverviewofrecentresearchadvances |