In vitro Activity of Eravacycline and Risk Factors for Carbapenem-Resistant Acinetobacter Baumannii Infections in Patients with Respiratory Diseases: A Retrospective Cohort Study
Jiahao Guan,1,* Zitong Wang,1,2,* Yihan Dong,1,2 Jun Wang,3 Yajuan Ren,4 Zifan Lu,5 Shuling Hu,1 Xianglong Duan6 1Department of Clinical Laboratory, Shaanxi Provincial People′s Hospital, Xi ′an, People’s Republic of China; 2Medical College, Yan’ an University, Yan’ an, People...
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Dove Medical Press
2025-06-01
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| author | Guan J Wang Z Dong Y Wang J Ren Y Lu Z Hu S Duan X |
| author_facet | Guan J Wang Z Dong Y Wang J Ren Y Lu Z Hu S Duan X |
| author_sort | Guan J |
| collection | DOAJ |
| description | Jiahao Guan,1,&ast; Zitong Wang,1,2,&ast; Yihan Dong,1,2 Jun Wang,3 Yajuan Ren,4 Zifan Lu,5 Shuling Hu,1 Xianglong Duan6 1Department of Clinical Laboratory, Shaanxi Provincial People′s Hospital, Xi ′an, People’s Republic of China; 2Medical College, Yan’ an University, Yan’ an, People’s Republic of China; 3Department of Respiratory MedicineI, Shaanxi Provincial People’s Hospital, Xi ′an, People’s Republic of China; 4Department of Respiratory Medicine II, Shaanxi Provincial People’s Hospital, Xi ′an, People’s Republic of China; 5Translational medicine Center, Shaanxi Provincial People’s Hospital, Xi ′an, People’s Republic of China; 6Second Department of General Surgery, Shaanxi Provincial People’s Hospital, Xi ′an, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Xianglong Duan, Second Department of General Surgery, Shaanxi Provincial People′s Hospital, No. 256, Youyi West Road, Xi’an, Shaanxi, 710068, People’s Republic of China, Tel +86 029-85251331, Email duanxianglong@nwpu.edu.cnBackground: Carbapenem-resistant Acinetobacter baumannii (CRAB) infections, particularly among respiratory patients, are associated with high mortality rates and substantial healthcare costs, exceeding &dollar;1.2 billion annually. Current the medications are recommended therapies, including Colistin and Tigecycline, face significant limitations, such as nephrotoxicity and inadequate lung tissue penetration. In contrast, Eravacycline (ERV), a novel fluorocycline, exhibits potent activity against multidrug-resistant Gram-negative pathogens and may help mitigate these limitations.Patients and Methods: A retrospective analysis was conducted on 1071 CRAB isolates obtained from 524 respiratory patients at Shaanxi Provincial People’s Hospital in 2024. Bacterial identification was performed using mass spectrometry (Zhongyuan Co). while drug susceptibility testing was carried out using the BD Phoenix M50 (Becton Dickinson) and E-test strips (Liofilchem). Multivariable logistic regression was applied to identify independent risk factors, including age, intubation history, comorbidities, and the use of feeding tubes, with adjusted odds ratios (OR), 95% confidence intervals (CI), and P-values reported.Results: Tracheal intubation emerged as the strongest independent risk factor for CRAB acquisition (OR=3.325, 95% CI: 2.273– 4.865, P< 0.001). Resistance to β-lactam antibiotics exceeded 96% (Ceftazidime: 96.56%, Ceftriaxone: 97.14%). C-reactive Protein (CRP) (OR=1.001, 95% CI: 0.996– 1.006, P=0.004) and interleukin-6 (IL-6) (P< 0.001) independently predicted mortality, with SAA demonstrating a strong association with risk (OR = 1.001, 95% CI: 0.999– 1.002, P = 0.006).Conclusion: Endotracheal intubation significantly contributes to the transmission of CRAB, underscoring the necessity for employing early respiratory ventilation and ERV as a recommended therapies therapeutic strategy in environments with elevated β-lactam resistance. Serum amyloid A (SAA) and interleukin-6 (IL-6) are important prognostic biomarkers that facilitate risk stratification. The implementation of infection control measures that prioritize intubation-associated practices is essential for alleviating the burden of CRAB infections.Keywords: eravacycline, carbapenem-resistant Acinetobacter baumannii, multidrug resistance, hospital-acquired infections, respiratory diseases, biomarkers |
| format | Article |
| id | doaj-art-d355898dd9eb4264bcc756d6c52b1fef |
| institution | Kabale University |
| issn | 1178-6973 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Dove Medical Press |
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| series | Infection and Drug Resistance |
| spelling | doaj-art-d355898dd9eb4264bcc756d6c52b1fef2025-08-20T03:29:49ZengDove Medical PressInfection and Drug Resistance1178-69732025-06-01Volume 18Issue 131273136104205In vitro Activity of Eravacycline and Risk Factors for Carbapenem-Resistant Acinetobacter Baumannii Infections in Patients with Respiratory Diseases: A Retrospective Cohort StudyGuan J0Wang ZDong Y1Wang JRen YLu Z2Hu SDuan X3Shaanxi Provincial People′s HospitalYan' an University；Medical Laboratory Center of Shaanxi Provincial People′s Hospital, Xi ′anShaanxi Provincial Key Laboratory of Infection and Immune DiseasesSecond Department of General SurgeryJiahao Guan,1,&ast; Zitong Wang,1,2,&ast; Yihan Dong,1,2 Jun Wang,3 Yajuan Ren,4 Zifan Lu,5 Shuling Hu,1 Xianglong Duan6 1Department of Clinical Laboratory, Shaanxi Provincial People′s Hospital, Xi ′an, People’s Republic of China; 2Medical College, Yan’ an University, Yan’ an, People’s Republic of China; 3Department of Respiratory MedicineI, Shaanxi Provincial People’s Hospital, Xi ′an, People’s Republic of China; 4Department of Respiratory Medicine II, Shaanxi Provincial People’s Hospital, Xi ′an, People’s Republic of China; 5Translational medicine Center, Shaanxi Provincial People’s Hospital, Xi ′an, People’s Republic of China; 6Second Department of General Surgery, Shaanxi Provincial People’s Hospital, Xi ′an, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Xianglong Duan, Second Department of General Surgery, Shaanxi Provincial People′s Hospital, No. 256, Youyi West Road, Xi’an, Shaanxi, 710068, People’s Republic of China, Tel +86 029-85251331, Email duanxianglong@nwpu.edu.cnBackground: Carbapenem-resistant Acinetobacter baumannii (CRAB) infections, particularly among respiratory patients, are associated with high mortality rates and substantial healthcare costs, exceeding &dollar;1.2 billion annually. Current the medications are recommended therapies, including Colistin and Tigecycline, face significant limitations, such as nephrotoxicity and inadequate lung tissue penetration. In contrast, Eravacycline (ERV), a novel fluorocycline, exhibits potent activity against multidrug-resistant Gram-negative pathogens and may help mitigate these limitations.Patients and Methods: A retrospective analysis was conducted on 1071 CRAB isolates obtained from 524 respiratory patients at Shaanxi Provincial People’s Hospital in 2024. Bacterial identification was performed using mass spectrometry (Zhongyuan Co). while drug susceptibility testing was carried out using the BD Phoenix M50 (Becton Dickinson) and E-test strips (Liofilchem). Multivariable logistic regression was applied to identify independent risk factors, including age, intubation history, comorbidities, and the use of feeding tubes, with adjusted odds ratios (OR), 95% confidence intervals (CI), and P-values reported.Results: Tracheal intubation emerged as the strongest independent risk factor for CRAB acquisition (OR=3.325, 95% CI: 2.273– 4.865, P< 0.001). Resistance to β-lactam antibiotics exceeded 96% (Ceftazidime: 96.56%, Ceftriaxone: 97.14%). C-reactive Protein (CRP) (OR=1.001, 95% CI: 0.996– 1.006, P=0.004) and interleukin-6 (IL-6) (P< 0.001) independently predicted mortality, with SAA demonstrating a strong association with risk (OR = 1.001, 95% CI: 0.999– 1.002, P = 0.006).Conclusion: Endotracheal intubation significantly contributes to the transmission of CRAB, underscoring the necessity for employing early respiratory ventilation and ERV as a recommended therapies therapeutic strategy in environments with elevated β-lactam resistance. Serum amyloid A (SAA) and interleukin-6 (IL-6) are important prognostic biomarkers that facilitate risk stratification. The implementation of infection control measures that prioritize intubation-associated practices is essential for alleviating the burden of CRAB infections.Keywords: eravacycline, carbapenem-resistant Acinetobacter baumannii, multidrug resistance, hospital-acquired infections, respiratory diseases, biomarkershttps://www.dovepress.com/in-vitro-activity-of-eravacycline-and-risk-factors-for-carbapenem-resi-peer-reviewed-fulltext-article-IDREravacyclineCarbapenem-resistant Acinetobacter baumanniimultidrug resistancehospital-acquired infectionsrespiratory diseasesbiomarkers |
| spellingShingle | Guan J Wang Z Dong Y Wang J Ren Y Lu Z Hu S Duan X In vitro Activity of Eravacycline and Risk Factors for Carbapenem-Resistant Acinetobacter Baumannii Infections in Patients with Respiratory Diseases: A Retrospective Cohort Study Infection and Drug Resistance Eravacycline Carbapenem-resistant Acinetobacter baumannii multidrug resistance hospital-acquired infections respiratory diseases biomarkers |
| title | In vitro Activity of Eravacycline and Risk Factors for Carbapenem-Resistant Acinetobacter Baumannii Infections in Patients with Respiratory Diseases: A Retrospective Cohort Study |
| title_full | In vitro Activity of Eravacycline and Risk Factors for Carbapenem-Resistant Acinetobacter Baumannii Infections in Patients with Respiratory Diseases: A Retrospective Cohort Study |
| title_fullStr | In vitro Activity of Eravacycline and Risk Factors for Carbapenem-Resistant Acinetobacter Baumannii Infections in Patients with Respiratory Diseases: A Retrospective Cohort Study |
| title_full_unstemmed | In vitro Activity of Eravacycline and Risk Factors for Carbapenem-Resistant Acinetobacter Baumannii Infections in Patients with Respiratory Diseases: A Retrospective Cohort Study |
| title_short | In vitro Activity of Eravacycline and Risk Factors for Carbapenem-Resistant Acinetobacter Baumannii Infections in Patients with Respiratory Diseases: A Retrospective Cohort Study |
| title_sort | in vitro activity of eravacycline and risk factors for carbapenem resistant acinetobacter baumannii infections in patients with respiratory diseases a retrospective cohort study |
| topic | Eravacycline Carbapenem-resistant Acinetobacter baumannii multidrug resistance hospital-acquired infections respiratory diseases biomarkers |
| url | https://www.dovepress.com/in-vitro-activity-of-eravacycline-and-risk-factors-for-carbapenem-resi-peer-reviewed-fulltext-article-IDR |
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