The Impact of Coagulation Biomarkers on Survival Outcomes in Adult Glioblastoma
<i>Background and Objectives</i>: Glioblastoma presents a significant challenge in oncology due to its aggressive nature and poor prognosis, despite advancements in treatment. This study aims to comprehensively evaluate the prognostic significance of coagulation biomarkers, including the...
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MDPI AG
2025-04-01
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| author | Rahmi Atıl Aksoy Timur Koca Yasemin Şengün Ece Atak Aylin Fidan Korcum |
| author_facet | Rahmi Atıl Aksoy Timur Koca Yasemin Şengün Ece Atak Aylin Fidan Korcum |
| author_sort | Rahmi Atıl Aksoy |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: Glioblastoma presents a significant challenge in oncology due to its aggressive nature and poor prognosis, despite advancements in treatment. This study aims to comprehensively evaluate the prognostic significance of coagulation biomarkers, including the novel albumin/D-dimer ratio, in adult glioblastoma patients. <i>Material and Methods</i>: This retrospective study included 74 adult glioblastoma patients who underwent Stupp protocol treatment. Blood samples were collected before radiotherapy to measure biomarkers, including prothrombin time (PT), activated partial thromboplastin time (aPTT), albumin, D-dimer, and the albumin/D-dimer ratio. The prognostic significance of these biomarkers for progression-free survival (PFS) and overall survival (OS) was assessed using both univariate and multivariate Cox regression analyses. <i>Results</i>: The median follow-up time was 12.2 months (range, 1–77.4 months). Univariate analysis revealed that ECOG performance status (<i>p</i> = 0.001), D-dimer (<i>p</i> = 0.03), and albumin (<i>p</i> = 0.001) were significant prognostic factors for PFS. Multivariate analysis identified albumin (<i>p</i> = 0.02) as an independent prognostic biomarker for PFS. For OS, univariate analysis showed that age (<i>p</i> = 0.004), ECOG performance status (<i>p</i> = 0.001), tumor volume (<i>p</i> = 0.007), extent of resection (<i>p</i> = 0.01), radiotherapy dose (<i>p</i> = 0.001), D-dimer (<i>p</i> = 0.02), albumin (<i>p</i> = 0.001), albumin/D-dimer ratio (<i>p</i> = 0.02), and PT (<i>p</i> = 0.002) were significant prognostic factors. Multivariate analysis revealed age (<i>p</i> = 0.04), extent of resection (<i>p</i> = 0.02), and PT (<i>p</i> = 0.04) as independent prognostic factors for OS. <i>Conclusions</i>: Our findings highlight the prognostic significance of coagulation biomarkers, particularly PT, D-dimer, albumin, and the albumin/D-dimer ratio, in glioblastoma. These biomarkers may serve as valuable tools for prognostic assessment and personalized treatment strategies, warranting further exploration in larger prospective studies. |
| format | Article |
| id | doaj-art-d346fcff4b364cc298f1774b5dd49a00 |
| institution | OA Journals |
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| language | English |
| publishDate | 2025-04-01 |
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| spelling | doaj-art-d346fcff4b364cc298f1774b5dd49a002025-08-20T02:28:37ZengMDPI AGMedicina1010-660X1648-91442025-04-0161475610.3390/medicina61040756The Impact of Coagulation Biomarkers on Survival Outcomes in Adult GlioblastomaRahmi Atıl Aksoy0Timur Koca1Yasemin Şengün2Ece Atak3Aylin Fidan Korcum4Department of Radiation Oncology, Akdeniz University Faculty of Medicine, Antalya 07070, TurkeyDepartment of Radiation Oncology, Akdeniz University Faculty of Medicine, Antalya 07070, TurkeyDepartment of Radiation Oncology, Akdeniz University Faculty of Medicine, Antalya 07070, TurkeyDepartment of Radiation Oncology, Akdeniz University Faculty of Medicine, Antalya 07070, TurkeyDepartment of Radiation Oncology, Akdeniz University Faculty of Medicine, Antalya 07070, Turkey<i>Background and Objectives</i>: Glioblastoma presents a significant challenge in oncology due to its aggressive nature and poor prognosis, despite advancements in treatment. This study aims to comprehensively evaluate the prognostic significance of coagulation biomarkers, including the novel albumin/D-dimer ratio, in adult glioblastoma patients. <i>Material and Methods</i>: This retrospective study included 74 adult glioblastoma patients who underwent Stupp protocol treatment. Blood samples were collected before radiotherapy to measure biomarkers, including prothrombin time (PT), activated partial thromboplastin time (aPTT), albumin, D-dimer, and the albumin/D-dimer ratio. The prognostic significance of these biomarkers for progression-free survival (PFS) and overall survival (OS) was assessed using both univariate and multivariate Cox regression analyses. <i>Results</i>: The median follow-up time was 12.2 months (range, 1–77.4 months). Univariate analysis revealed that ECOG performance status (<i>p</i> = 0.001), D-dimer (<i>p</i> = 0.03), and albumin (<i>p</i> = 0.001) were significant prognostic factors for PFS. Multivariate analysis identified albumin (<i>p</i> = 0.02) as an independent prognostic biomarker for PFS. For OS, univariate analysis showed that age (<i>p</i> = 0.004), ECOG performance status (<i>p</i> = 0.001), tumor volume (<i>p</i> = 0.007), extent of resection (<i>p</i> = 0.01), radiotherapy dose (<i>p</i> = 0.001), D-dimer (<i>p</i> = 0.02), albumin (<i>p</i> = 0.001), albumin/D-dimer ratio (<i>p</i> = 0.02), and PT (<i>p</i> = 0.002) were significant prognostic factors. Multivariate analysis revealed age (<i>p</i> = 0.04), extent of resection (<i>p</i> = 0.02), and PT (<i>p</i> = 0.04) as independent prognostic factors for OS. <i>Conclusions</i>: Our findings highlight the prognostic significance of coagulation biomarkers, particularly PT, D-dimer, albumin, and the albumin/D-dimer ratio, in glioblastoma. These biomarkers may serve as valuable tools for prognostic assessment and personalized treatment strategies, warranting further exploration in larger prospective studies.https://www.mdpi.com/1648-9144/61/4/756glioblastomacoagulationprothrombin timeD-dimeralbuminsurvival |
| spellingShingle | Rahmi Atıl Aksoy Timur Koca Yasemin Şengün Ece Atak Aylin Fidan Korcum The Impact of Coagulation Biomarkers on Survival Outcomes in Adult Glioblastoma Medicina glioblastoma coagulation prothrombin time D-dimer albumin survival |
| title | The Impact of Coagulation Biomarkers on Survival Outcomes in Adult Glioblastoma |
| title_full | The Impact of Coagulation Biomarkers on Survival Outcomes in Adult Glioblastoma |
| title_fullStr | The Impact of Coagulation Biomarkers on Survival Outcomes in Adult Glioblastoma |
| title_full_unstemmed | The Impact of Coagulation Biomarkers on Survival Outcomes in Adult Glioblastoma |
| title_short | The Impact of Coagulation Biomarkers on Survival Outcomes in Adult Glioblastoma |
| title_sort | impact of coagulation biomarkers on survival outcomes in adult glioblastoma |
| topic | glioblastoma coagulation prothrombin time D-dimer albumin survival |
| url | https://www.mdpi.com/1648-9144/61/4/756 |
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