Metastatin as a Marker for Hyperandrogenemia in Iraqi Women with Polycystic Ovary Syndrome
Objective. Kisspeptin 1 might reflect increased androgen level in polycystic ovarian syndrome instead of other markers. Study Design. A case control study was performed in Al-Yarmouk Teaching Hospital from 1st of July 2016 to 1st of July 2017; it involved 87 women divided into two groups: 44 women d...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | Obstetrics and Gynecology International |
| Online Access: | http://dx.doi.org/10.1155/2020/5216903 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849473271067574272 |
|---|---|
| author | Manal Madany Abdalqader Shatha Sami Hussein |
| author_facet | Manal Madany Abdalqader Shatha Sami Hussein |
| author_sort | Manal Madany Abdalqader |
| collection | DOAJ |
| description | Objective. Kisspeptin 1 might reflect increased androgen level in polycystic ovarian syndrome instead of other markers. Study Design. A case control study was performed in Al-Yarmouk Teaching Hospital from 1st of July 2016 to 1st of July 2017; it involved 87 women divided into two groups: 44 women diagnosed as PCOS, 22 women with BMI ≥ 25 kg/m2 and 22 women with BMI < 25 kg/m2, and another 43 women without PCOS, 22 women with BMI ≥ 25 kg/m2 and 21 women with BMI < 25 kg/m2. Hormonal, metabolic profiles, and hirsutism scores, as well as serum kisspeptin level, were assessed by using Human Kisspeptin 1(KISS-1) ELISA Kit. The blood samples between days 2 and 5 of menstrual cycle were drawn by an disposable sterile syringe and collected in EDTA containing tubes (as anticoagulant), and the hormonal profile was measured using a biotech ELISA reader. Result. Serum level of kisspeptin was significantly higher in PCOS compared to control (322.4 vs. 235.3 ng/L, respectively). There was no significant difference in age, BMI, and parity between control and PCOS; the frequency of hirsutism, acne, elevated LH, and increased free testosterone (fTT) were significantly higher in PCOS compared to control. Kisspeptin shows a direct significant correlation with hirsutism and fTT (r = 0.648, 0.238, respectively). In ROC analysis, kisspeptin had AUC (95% CI) = 0.874 (0.785–0.935) for predicting PCOS. Conclusion. Kisspeptin levels might be used as a marker for hyperandrogenemia in polycystic ovarian syndrome. |
| format | Article |
| id | doaj-art-d344f3b991b34c8e8b9bb977d0ba4777 |
| institution | Kabale University |
| issn | 1687-9589 1687-9597 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Obstetrics and Gynecology International |
| spelling | doaj-art-d344f3b991b34c8e8b9bb977d0ba47772025-08-20T03:24:12ZengWileyObstetrics and Gynecology International1687-95891687-95972020-01-01202010.1155/2020/52169035216903Metastatin as a Marker for Hyperandrogenemia in Iraqi Women with Polycystic Ovary SyndromeManal Madany Abdalqader0Shatha Sami Hussein1College of Medicine, Department of Obstetrics &Gynecology, Al-Mustansiriyah University, Baghdad, IraqCollege of Medicine, Department of Obstetrics &Gynecology, Al-Mustansiriyah University, Baghdad, IraqObjective. Kisspeptin 1 might reflect increased androgen level in polycystic ovarian syndrome instead of other markers. Study Design. A case control study was performed in Al-Yarmouk Teaching Hospital from 1st of July 2016 to 1st of July 2017; it involved 87 women divided into two groups: 44 women diagnosed as PCOS, 22 women with BMI ≥ 25 kg/m2 and 22 women with BMI < 25 kg/m2, and another 43 women without PCOS, 22 women with BMI ≥ 25 kg/m2 and 21 women with BMI < 25 kg/m2. Hormonal, metabolic profiles, and hirsutism scores, as well as serum kisspeptin level, were assessed by using Human Kisspeptin 1(KISS-1) ELISA Kit. The blood samples between days 2 and 5 of menstrual cycle were drawn by an disposable sterile syringe and collected in EDTA containing tubes (as anticoagulant), and the hormonal profile was measured using a biotech ELISA reader. Result. Serum level of kisspeptin was significantly higher in PCOS compared to control (322.4 vs. 235.3 ng/L, respectively). There was no significant difference in age, BMI, and parity between control and PCOS; the frequency of hirsutism, acne, elevated LH, and increased free testosterone (fTT) were significantly higher in PCOS compared to control. Kisspeptin shows a direct significant correlation with hirsutism and fTT (r = 0.648, 0.238, respectively). In ROC analysis, kisspeptin had AUC (95% CI) = 0.874 (0.785–0.935) for predicting PCOS. Conclusion. Kisspeptin levels might be used as a marker for hyperandrogenemia in polycystic ovarian syndrome.http://dx.doi.org/10.1155/2020/5216903 |
| spellingShingle | Manal Madany Abdalqader Shatha Sami Hussein Metastatin as a Marker for Hyperandrogenemia in Iraqi Women with Polycystic Ovary Syndrome Obstetrics and Gynecology International |
| title | Metastatin as a Marker for Hyperandrogenemia in Iraqi Women with Polycystic Ovary Syndrome |
| title_full | Metastatin as a Marker for Hyperandrogenemia in Iraqi Women with Polycystic Ovary Syndrome |
| title_fullStr | Metastatin as a Marker for Hyperandrogenemia in Iraqi Women with Polycystic Ovary Syndrome |
| title_full_unstemmed | Metastatin as a Marker for Hyperandrogenemia in Iraqi Women with Polycystic Ovary Syndrome |
| title_short | Metastatin as a Marker for Hyperandrogenemia in Iraqi Women with Polycystic Ovary Syndrome |
| title_sort | metastatin as a marker for hyperandrogenemia in iraqi women with polycystic ovary syndrome |
| url | http://dx.doi.org/10.1155/2020/5216903 |
| work_keys_str_mv | AT manalmadanyabdalqader metastatinasamarkerforhyperandrogenemiainiraqiwomenwithpolycysticovarysyndrome AT shathasamihussein metastatinasamarkerforhyperandrogenemiainiraqiwomenwithpolycysticovarysyndrome |