Treatment of Aggressive NK-Cell Leukemia: A Case Report and Review of the Literature
Aggressive NK-cell leukemia is a rare malignancy with neoplastic proliferation of natural killer cells. It often presents with constitutional symptoms, a rapid declining clinical course, and a poor prognosis with a median survival of a few months. The disease is usually resistant to cytotoxic agents...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2011/818469 |
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| _version_ | 1850173449616490496 |
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| author | Anders Kindberg Boysen Paw Jensen Preben Johansen Karen Dybkær Mette Nyegaard |
| author_facet | Anders Kindberg Boysen Paw Jensen Preben Johansen Karen Dybkær Mette Nyegaard |
| author_sort | Anders Kindberg Boysen |
| collection | DOAJ |
| description | Aggressive NK-cell leukemia is a rare malignancy with neoplastic proliferation of natural killer cells. It often presents with constitutional symptoms, a rapid declining clinical course, and a poor prognosis with a median survival of a few months. The disease is usually resistant to cytotoxic agents, and no treatment has emerged as the standard of care for these patients. We report a case of an 18-year-old male who obtains complete remission following two lines of combination chemotherapy. We describe in details our regimens for induction chemotherapy and perform a review of existing literature concerning treatment of aggressive NK-cell leukemia. |
| format | Article |
| id | doaj-art-d344b6313bbd4347ac200d48d731f9c2 |
| institution | OA Journals |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-d344b6313bbd4347ac200d48d731f9c22025-08-20T02:19:51ZengWileyCase Reports in Hematology2090-65602090-65792011-01-01201110.1155/2011/818469818469Treatment of Aggressive NK-Cell Leukemia: A Case Report and Review of the LiteratureAnders Kindberg Boysen0Paw Jensen1Preben Johansen2Karen Dybkær3Mette Nyegaard4Department of Hematology, Aalborg Hospital, Aarhus University Hospital, Hobrovej 18-22, P.O. Box 365, 9100 Aalborg, DenmarkDepartment of Hematology, Aalborg Hospital, Aarhus University Hospital, Hobrovej 18-22, P.O. Box 365, 9100 Aalborg, DenmarkDepartment of Pathology, Aalborg Hospital, Aarhus University Hospital, 9100 Aalborg, DenmarkDepartment of Hematology, Aalborg Hospital, Aarhus University Hospital, Hobrovej 18-22, P.O. Box 365, 9100 Aalborg, DenmarkDepartment of Hematology, Aalborg Hospital, Aarhus University Hospital, Hobrovej 18-22, P.O. Box 365, 9100 Aalborg, DenmarkAggressive NK-cell leukemia is a rare malignancy with neoplastic proliferation of natural killer cells. It often presents with constitutional symptoms, a rapid declining clinical course, and a poor prognosis with a median survival of a few months. The disease is usually resistant to cytotoxic agents, and no treatment has emerged as the standard of care for these patients. We report a case of an 18-year-old male who obtains complete remission following two lines of combination chemotherapy. We describe in details our regimens for induction chemotherapy and perform a review of existing literature concerning treatment of aggressive NK-cell leukemia.http://dx.doi.org/10.1155/2011/818469 |
| spellingShingle | Anders Kindberg Boysen Paw Jensen Preben Johansen Karen Dybkær Mette Nyegaard Treatment of Aggressive NK-Cell Leukemia: A Case Report and Review of the Literature Case Reports in Hematology |
| title | Treatment of Aggressive NK-Cell Leukemia: A Case Report and Review of the Literature |
| title_full | Treatment of Aggressive NK-Cell Leukemia: A Case Report and Review of the Literature |
| title_fullStr | Treatment of Aggressive NK-Cell Leukemia: A Case Report and Review of the Literature |
| title_full_unstemmed | Treatment of Aggressive NK-Cell Leukemia: A Case Report and Review of the Literature |
| title_short | Treatment of Aggressive NK-Cell Leukemia: A Case Report and Review of the Literature |
| title_sort | treatment of aggressive nk cell leukemia a case report and review of the literature |
| url | http://dx.doi.org/10.1155/2011/818469 |
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