Development and validation of a population pharmacokinetic model to guide perioperative tacrolimus dosing after lung transplantation

Development and validation of a population pharmacokinetic model to guide perioperative tacrolimus dosing after lung transplantation

Background: Tacrolimus therapy is standard of care for immunosuppression after lung transplantation. However, tacrolimus exposure variability during the early postoperative period may contribute to poor outcomes in this population. Few studies have examined tacrolimus pharmacokinetics (PK) during th...

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Main Authors: Todd A. Miano, PharmD, PhD, Athena F. Zuppa, MD, MSCE, Rui Feng, PhD, Stephen Griffiths, BS, Laurel Kalman, BA, Michelle Oyster, MS, Edward Cantu, MD, MSCE, Wei Yang, PhD, Joshua M. Diamond, MD, MSCE, Jason D. Christie, MD, MSCE, Marc H. Scheetz, PharmD, MSC, Michael G.S. Shashaty, MD, MSCE
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:JHLT Open
Subjects:
tacrolimus
lung transplantation
pharmacokinetics
precision dosing
pharmacogenetics
critical illness
Online Access:http://www.sciencedirect.com/science/article/pii/S2950133424000831
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