Intratympanic steroid injection adjunct to myringotomy with ventilation tube insertion for otitis media with effusion in children with cleft palate – a matched pair randomized controlled trial
Background: To evaluate the efficacy of adjunctive intratympanic dexamethasone therapy in improving outcomes of myringotomy with ventilation tube insertion for bilateral otitis media with effusion in children with cleft palate. Methods: Children with cleft palate aged 2–12 years were recruited. Dexa...
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SAGE Publishing
2025-06-01
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| Series: | SAGE Open Medicine |
| Online Access: | https://doi.org/10.1177/20503121251348026 |
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| author | Patorn Piromchai Jutarat Anutragulchai Kwanchanok Yimtae Somchai Srirompotong Panida Thanawirattananit |
| author_facet | Patorn Piromchai Jutarat Anutragulchai Kwanchanok Yimtae Somchai Srirompotong Panida Thanawirattananit |
| author_sort | Patorn Piromchai |
| collection | DOAJ |
| description | Background: To evaluate the efficacy of adjunctive intratympanic dexamethasone therapy in improving outcomes of myringotomy with ventilation tube insertion for bilateral otitis media with effusion in children with cleft palate. Methods: Children with cleft palate aged 2–12 years were recruited. Dexamethasone or placebo was administered intratympanically based on randomized allocation, with contralateral ear receiving the alternate treatment. Results: Twenty-three children with cleft palate (mean age: 33.04 ± 27.80 months) were enrolled. Baseline demographics were comparable between groups ( p > 0.05). Both dexamethasone and placebo groups demonstrated significant hearing level improvements at 1-month follow-up ( p < 0.001). Patients with otitis media with effusion duration ⩽ 3 months exhibited superior outcomes in the dexamethasone group (mean difference: −3.18 dB HL, 95% CI: −4.88 to −1.49, p = 0.002). Patients with cleft palate without other anomalies demonstrated a significant improvement in the dexamethasone group (mean difference: −3.24 dB HL, 95% CI: −5.04 to −1.43, p = 0.002). No significant differences in adverse events were observed between groups ( p > 0.05). Conclusions: Early intratympanic dexamethasone injection adjunct to myringotomy with ventilation tube insertion is recommended for otitis media with effusion in children with cleft palate. |
| format | Article |
| id | doaj-art-d3426a8a02bd464faa3253dd5c747573 |
| institution | Kabale University |
| issn | 2050-3121 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | SAGE Open Medicine |
| spelling | doaj-art-d3426a8a02bd464faa3253dd5c7475732025-08-20T03:30:57ZengSAGE PublishingSAGE Open Medicine2050-31212025-06-011310.1177/20503121251348026Intratympanic steroid injection adjunct to myringotomy with ventilation tube insertion for otitis media with effusion in children with cleft palate – a matched pair randomized controlled trialPatorn Piromchai0Jutarat Anutragulchai1Kwanchanok Yimtae2Somchai Srirompotong3Panida Thanawirattananit4Faculty of Medicine, Department of Otorhinolaryngology, Khon Kaen University, Muang Khon Kaen, ThailandFaculty of Medicine, Department of Otorhinolaryngology, Khon Kaen University, Muang Khon Kaen, ThailandFaculty of Medicine, Department of Otorhinolaryngology, Khon Kaen University, Muang Khon Kaen, ThailandFaculty of Medicine, Department of Otorhinolaryngology, Khon Kaen University, Muang Khon Kaen, ThailandFaculty of Medicine, Department of Otorhinolaryngology, Khon Kaen University, Muang Khon Kaen, ThailandBackground: To evaluate the efficacy of adjunctive intratympanic dexamethasone therapy in improving outcomes of myringotomy with ventilation tube insertion for bilateral otitis media with effusion in children with cleft palate. Methods: Children with cleft palate aged 2–12 years were recruited. Dexamethasone or placebo was administered intratympanically based on randomized allocation, with contralateral ear receiving the alternate treatment. Results: Twenty-three children with cleft palate (mean age: 33.04 ± 27.80 months) were enrolled. Baseline demographics were comparable between groups ( p > 0.05). Both dexamethasone and placebo groups demonstrated significant hearing level improvements at 1-month follow-up ( p < 0.001). Patients with otitis media with effusion duration ⩽ 3 months exhibited superior outcomes in the dexamethasone group (mean difference: −3.18 dB HL, 95% CI: −4.88 to −1.49, p = 0.002). Patients with cleft palate without other anomalies demonstrated a significant improvement in the dexamethasone group (mean difference: −3.24 dB HL, 95% CI: −5.04 to −1.43, p = 0.002). No significant differences in adverse events were observed between groups ( p > 0.05). Conclusions: Early intratympanic dexamethasone injection adjunct to myringotomy with ventilation tube insertion is recommended for otitis media with effusion in children with cleft palate.https://doi.org/10.1177/20503121251348026 |
| spellingShingle | Patorn Piromchai Jutarat Anutragulchai Kwanchanok Yimtae Somchai Srirompotong Panida Thanawirattananit Intratympanic steroid injection adjunct to myringotomy with ventilation tube insertion for otitis media with effusion in children with cleft palate – a matched pair randomized controlled trial SAGE Open Medicine |
| title | Intratympanic steroid injection adjunct to myringotomy with ventilation tube insertion for otitis media with effusion in children with cleft palate – a matched pair randomized controlled trial |
| title_full | Intratympanic steroid injection adjunct to myringotomy with ventilation tube insertion for otitis media with effusion in children with cleft palate – a matched pair randomized controlled trial |
| title_fullStr | Intratympanic steroid injection adjunct to myringotomy with ventilation tube insertion for otitis media with effusion in children with cleft palate – a matched pair randomized controlled trial |
| title_full_unstemmed | Intratympanic steroid injection adjunct to myringotomy with ventilation tube insertion for otitis media with effusion in children with cleft palate – a matched pair randomized controlled trial |
| title_short | Intratympanic steroid injection adjunct to myringotomy with ventilation tube insertion for otitis media with effusion in children with cleft palate – a matched pair randomized controlled trial |
| title_sort | intratympanic steroid injection adjunct to myringotomy with ventilation tube insertion for otitis media with effusion in children with cleft palate a matched pair randomized controlled trial |
| url | https://doi.org/10.1177/20503121251348026 |
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