Intratympanic steroid injection adjunct to myringotomy with ventilation tube insertion for otitis media with effusion in children with cleft palate – a matched pair randomized controlled trial
Background: To evaluate the efficacy of adjunctive intratympanic dexamethasone therapy in improving outcomes of myringotomy with ventilation tube insertion for bilateral otitis media with effusion in children with cleft palate. Methods: Children with cleft palate aged 2–12 years were recruited. Dexa...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2025-06-01
|
| Series: | SAGE Open Medicine |
| Online Access: | https://doi.org/10.1177/20503121251348026 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Background: To evaluate the efficacy of adjunctive intratympanic dexamethasone therapy in improving outcomes of myringotomy with ventilation tube insertion for bilateral otitis media with effusion in children with cleft palate. Methods: Children with cleft palate aged 2–12 years were recruited. Dexamethasone or placebo was administered intratympanically based on randomized allocation, with contralateral ear receiving the alternate treatment. Results: Twenty-three children with cleft palate (mean age: 33.04 ± 27.80 months) were enrolled. Baseline demographics were comparable between groups ( p > 0.05). Both dexamethasone and placebo groups demonstrated significant hearing level improvements at 1-month follow-up ( p < 0.001). Patients with otitis media with effusion duration ⩽ 3 months exhibited superior outcomes in the dexamethasone group (mean difference: −3.18 dB HL, 95% CI: −4.88 to −1.49, p = 0.002). Patients with cleft palate without other anomalies demonstrated a significant improvement in the dexamethasone group (mean difference: −3.24 dB HL, 95% CI: −5.04 to −1.43, p = 0.002). No significant differences in adverse events were observed between groups ( p > 0.05). Conclusions: Early intratympanic dexamethasone injection adjunct to myringotomy with ventilation tube insertion is recommended for otitis media with effusion in children with cleft palate. |
|---|---|
| ISSN: | 2050-3121 |