Development of a novel PIK3CA-mutated pancreatic tumor mouse model and evaluation of the therapeutic effects of a PI3K inhibitor.

Development of a novel PIK3CA-mutated pancreatic tumor mouse model and evaluation of the therapeutic effects of a PI3K inhibitor.

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Pancreatic ductal adenocarcinoma (PDAC) is a fatal malignancy. Personalized medicine based on genetic mutations is required to improve its prognosis. The PI3K/AKT pathway plays a crucial role in cancer progression. While PI3K inhibitors have been developed for several malignancies, none have been cl...

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Main Authors: Yoshimasa Suzuki, Makoto Sugimori, Yushi Kanemaru, Sho Onodera, Hiromi Tsuchiya, Aya Ikeda, Ryosuke Ikeda, Yoshihiro Goda, Hiroaki Kaneko, Kuniyasu Irie, Soichiro Sue, Hideaki Ijichi, Shin Maeda
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0326491
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