Utility of chest ultrasound and intrapleural fibrinolytics with gentamicin following failed pleurodesis
This is a case of a 65-year-old male patient who presented to our institution due to worsening dyspnea and respiratory failure development. The patient was admitted due to dyspnea at rest and chest pain. He had a recent medical history of lung cancer with malignant pleural effusion. The patient had...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2025-05-01
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| Series: | Monaldi Archives for Chest Disease |
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| Online Access: | https://www.monaldi-archives.org/macd/article/view/3224 |
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| author | Aldo Pezzuto Ferdinando Cozzolino Giosuè Amoroso Evohe Adone Elisa Desideri Alberto Ricci |
| author_facet | Aldo Pezzuto Ferdinando Cozzolino Giosuè Amoroso Evohe Adone Elisa Desideri Alberto Ricci |
| author_sort | Aldo Pezzuto |
| collection | DOAJ |
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This is a case of a 65-year-old male patient who presented to our institution due to worsening dyspnea and respiratory failure development. The patient was admitted due to dyspnea at rest and chest pain. He had a recent medical history of lung cancer with malignant pleural effusion. The patient had already undergone pleural talc poudrage by thoracoscopy, which had not been effective. Indeed, the patient was found to have residual septate pleural effusion on ultrasound examination. A placement of transthoracic pleural drainage followed by intrapleural instillation of urokinase (100,000 units) and gentamicin (80 mg) was performed within 30 days of chemical pleurodesis, achieving re-expansion of the lung by preventing recurrence of the effusion and leading to rapid clinical improvement. The novelty of the present case concerns the effectiveness of a combined treatment of fibrinolytic and intrapleural antibiotic through a pleural drainage after failure of chemical pleurodesis.
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| format | Article |
| id | doaj-art-d33e43ac145e4f4dbbfc746dfeb16eda |
| institution | OA Journals |
| issn | 1122-0643 2532-5264 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Monaldi Archives for Chest Disease |
| spelling | doaj-art-d33e43ac145e4f4dbbfc746dfeb16eda2025-08-20T01:57:09ZengPAGEPress PublicationsMonaldi Archives for Chest Disease1122-06432532-52642025-05-0110.4081/monaldi.2025.3224Utility of chest ultrasound and intrapleural fibrinolytics with gentamicin following failed pleurodesisAldo Pezzuto0https://orcid.org/0000-0002-6626-2260Ferdinando Cozzolino1https://orcid.org/0009-0008-3218-7283Giosuè Amoroso2https://orcid.org/0009-0004-7166-4469Evohe Adone3Elisa Desideri4Alberto Ricci5Department of Cardiovascular and Respiratory Sciences, Sapienza University, Sant’Andrea Hospital, RomeDepartment of Cardiovascular and Respiratory Sciences, Sapienza University, Sant’Andrea Hospital, RomeDepartment of Cardiovascular and Respiratory Sciences, Sapienza University, Sant’Andrea Hospital, RomeDepartment of Cardiovascular and Respiratory Sciences, Sapienza University, Sant’Andrea Hospital, RomeDepartment of Cardiovascular and Respiratory Sciences, Sapienza University, Sant’Andrea Hospital, RomeDepartment of Cardiovascular and Respiratory Sciences, Sapienza University, Sant’Andrea Hospital, Rome This is a case of a 65-year-old male patient who presented to our institution due to worsening dyspnea and respiratory failure development. The patient was admitted due to dyspnea at rest and chest pain. He had a recent medical history of lung cancer with malignant pleural effusion. The patient had already undergone pleural talc poudrage by thoracoscopy, which had not been effective. Indeed, the patient was found to have residual septate pleural effusion on ultrasound examination. A placement of transthoracic pleural drainage followed by intrapleural instillation of urokinase (100,000 units) and gentamicin (80 mg) was performed within 30 days of chemical pleurodesis, achieving re-expansion of the lung by preventing recurrence of the effusion and leading to rapid clinical improvement. The novelty of the present case concerns the effectiveness of a combined treatment of fibrinolytic and intrapleural antibiotic through a pleural drainage after failure of chemical pleurodesis. https://www.monaldi-archives.org/macd/article/view/3224Septate pleural effusionchemical pleurodesisintrapleural fibrinolysispleural drainagechest ultrasonography |
| spellingShingle | Aldo Pezzuto Ferdinando Cozzolino Giosuè Amoroso Evohe Adone Elisa Desideri Alberto Ricci Utility of chest ultrasound and intrapleural fibrinolytics with gentamicin following failed pleurodesis Monaldi Archives for Chest Disease Septate pleural effusion chemical pleurodesis intrapleural fibrinolysis pleural drainage chest ultrasonography |
| title | Utility of chest ultrasound and intrapleural fibrinolytics with gentamicin following failed pleurodesis |
| title_full | Utility of chest ultrasound and intrapleural fibrinolytics with gentamicin following failed pleurodesis |
| title_fullStr | Utility of chest ultrasound and intrapleural fibrinolytics with gentamicin following failed pleurodesis |
| title_full_unstemmed | Utility of chest ultrasound and intrapleural fibrinolytics with gentamicin following failed pleurodesis |
| title_short | Utility of chest ultrasound and intrapleural fibrinolytics with gentamicin following failed pleurodesis |
| title_sort | utility of chest ultrasound and intrapleural fibrinolytics with gentamicin following failed pleurodesis |
| topic | Septate pleural effusion chemical pleurodesis intrapleural fibrinolysis pleural drainage chest ultrasonography |
| url | https://www.monaldi-archives.org/macd/article/view/3224 |
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