Association Between Perinasal Uptake on Radioactive Iodine Whole-Body Scan and Nasolacrimal Duct Obstruction
<i>Background and Objectives:</i> This study reports an association between nasolacrimal duct obstruction (NLDO) and perinasal uptake on radioactive iodine (RAI) whole-body scan. <i>Materials and Methods</i>: This is a retrospective study of 37 patients from May to November 2...
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MDPI AG
2025-06-01
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| author | Minjung Seo Hongje Lee Na Ri Park Ju-Hyang Lee Seol Hoon Park |
| author_facet | Minjung Seo Hongje Lee Na Ri Park Ju-Hyang Lee Seol Hoon Park |
| author_sort | Minjung Seo |
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| description | <i>Background and Objectives:</i> This study reports an association between nasolacrimal duct obstruction (NLDO) and perinasal uptake on radioactive iodine (RAI) whole-body scan. <i>Materials and Methods</i>: This is a retrospective study of 37 patients from May to November 2017 who underwent thyroidectomy and I-131 ablation for papillary thyroid cancer (PTC) and had a follow-up I-123 diagnostic WBS and dacryoscintigraphy. Ophthalmic examinations assessed punctal stenosis, NLDO, tear film break-up time, Schirmer’s test, punctate keratopathy, tear meniscus height, epiphora, and ocular dryness. Perinasal and nasal uptake on whole-body scans (WBSs) were assessed as negative (no uptake) or positive (focal uptake). The associations between perinasal uptake on WBS, dacryoscintigraphy findings, and ophthalmic assessments were assessed. <i>Results</i>: Nasal uptake on I-131 post-ablation WBS were observed in 60 eyes (81%); perinasal uptake was observed in 8 eyes (11%). Nasal uptake on I-123 post-ablation WBS were observed in all eyes; perinasal uptake was observed in 15 eyes (20%). Perinasal and nasal uptake on I-131 post-ablation WBS were significantly associated with delayed excretion on dacryoscintigraphy (<i>p</i> < 0.001 and <i>p</i> = 0.03, respectively). Perinasal uptake on I-123 WBS was associated with both abnormal dacryoscintigraphy findings and ocular dryness (<i>p</i> < 0.001 and <i>p</i> = 0.02, respectively). <i>Conclusions</i>: Perinasal uptake on I-131 post-ablation and I-123 diagnostic WBS was significantly associated with delayed excretion on dacryoscintigraphy, suggesting NLDO. |
| format | Article |
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| issn | 1010-660X 1648-9144 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
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| series | Medicina |
| spelling | doaj-art-d33d80ea64a442aa9b1a4dbce054521a2025-08-20T03:08:09ZengMDPI AGMedicina1010-660X1648-91442025-06-01617116510.3390/medicina61071165Association Between Perinasal Uptake on Radioactive Iodine Whole-Body Scan and Nasolacrimal Duct ObstructionMinjung Seo0Hongje Lee1Na Ri Park2Ju-Hyang Lee3Seol Hoon Park4Department of Nuclear Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan 05505, Republic of KoreaDepartment of Nuclear Medicine, Dongnam Institution of Radiological & Medical Sciences (DIRAMS), Busan 46033, Republic of KoreaDepartment of Opthalmology, Ulsan University Hospital, Ulsan 44033, Republic of KoreaNamu Eye Clinic, Yongin-si 16841, Republic of KoreaDepartment of Nuclear Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan 05505, Republic of Korea<i>Background and Objectives:</i> This study reports an association between nasolacrimal duct obstruction (NLDO) and perinasal uptake on radioactive iodine (RAI) whole-body scan. <i>Materials and Methods</i>: This is a retrospective study of 37 patients from May to November 2017 who underwent thyroidectomy and I-131 ablation for papillary thyroid cancer (PTC) and had a follow-up I-123 diagnostic WBS and dacryoscintigraphy. Ophthalmic examinations assessed punctal stenosis, NLDO, tear film break-up time, Schirmer’s test, punctate keratopathy, tear meniscus height, epiphora, and ocular dryness. Perinasal and nasal uptake on whole-body scans (WBSs) were assessed as negative (no uptake) or positive (focal uptake). The associations between perinasal uptake on WBS, dacryoscintigraphy findings, and ophthalmic assessments were assessed. <i>Results</i>: Nasal uptake on I-131 post-ablation WBS were observed in 60 eyes (81%); perinasal uptake was observed in 8 eyes (11%). Nasal uptake on I-123 post-ablation WBS were observed in all eyes; perinasal uptake was observed in 15 eyes (20%). Perinasal and nasal uptake on I-131 post-ablation WBS were significantly associated with delayed excretion on dacryoscintigraphy (<i>p</i> < 0.001 and <i>p</i> = 0.03, respectively). Perinasal uptake on I-123 WBS was associated with both abnormal dacryoscintigraphy findings and ocular dryness (<i>p</i> < 0.001 and <i>p</i> = 0.02, respectively). <i>Conclusions</i>: Perinasal uptake on I-131 post-ablation and I-123 diagnostic WBS was significantly associated with delayed excretion on dacryoscintigraphy, suggesting NLDO.https://www.mdpi.com/1648-9144/61/7/1165nasolacrimal duct obstructionradioactive iodinewhole body scandacryoscintigraphy |
| spellingShingle | Minjung Seo Hongje Lee Na Ri Park Ju-Hyang Lee Seol Hoon Park Association Between Perinasal Uptake on Radioactive Iodine Whole-Body Scan and Nasolacrimal Duct Obstruction Medicina nasolacrimal duct obstruction radioactive iodine whole body scan dacryoscintigraphy |
| title | Association Between Perinasal Uptake on Radioactive Iodine Whole-Body Scan and Nasolacrimal Duct Obstruction |
| title_full | Association Between Perinasal Uptake on Radioactive Iodine Whole-Body Scan and Nasolacrimal Duct Obstruction |
| title_fullStr | Association Between Perinasal Uptake on Radioactive Iodine Whole-Body Scan and Nasolacrimal Duct Obstruction |
| title_full_unstemmed | Association Between Perinasal Uptake on Radioactive Iodine Whole-Body Scan and Nasolacrimal Duct Obstruction |
| title_short | Association Between Perinasal Uptake on Radioactive Iodine Whole-Body Scan and Nasolacrimal Duct Obstruction |
| title_sort | association between perinasal uptake on radioactive iodine whole body scan and nasolacrimal duct obstruction |
| topic | nasolacrimal duct obstruction radioactive iodine whole body scan dacryoscintigraphy |
| url | https://www.mdpi.com/1648-9144/61/7/1165 |
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