Rituximab-Associated Inflammatory Progressive Multifocal Leukoencephalopathy
Progressive multifocal leukoencephalopathy (PML) is a rare disease of the immunosuppression that results from neurotropic invasion of the JC virus which leads to demyelination of oligodendrocytes. Immune reconstitution inflammatory syndrome (IRIS), on the other hand, is a condition of inflammation t...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2016/8915047 |
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| _version_ | 1832554924476465152 |
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| author | Chandra Punch Christina Schofield Penelope Harris |
| author_facet | Chandra Punch Christina Schofield Penelope Harris |
| author_sort | Chandra Punch |
| collection | DOAJ |
| description | Progressive multifocal leukoencephalopathy (PML) is a rare disease of the immunosuppression that results from neurotropic invasion of the JC virus which leads to demyelination of oligodendrocytes. Immune reconstitution inflammatory syndrome (IRIS), on the other hand, is a condition of inflammation that develops as the immune system reconstitutes. This case report describes a case of a 35-year-old HIV-negative male who presented with three weeks of right lower extremity paresthesias as well as right upper extremity apraxia. He was diagnosed with PML complicated by IRIS secondary to Rituximab, which he had completed four months prior to presentation. Despite the condition’s poor prognosis, the patient recovered with only minor deficits. |
| format | Article |
| id | doaj-art-d33b3ac848424f3fa9c56a34a23fdc6e |
| institution | Kabale University |
| issn | 2090-6625 2090-6633 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Infectious Diseases |
| spelling | doaj-art-d33b3ac848424f3fa9c56a34a23fdc6e2025-02-03T05:50:11ZengWileyCase Reports in Infectious Diseases2090-66252090-66332016-01-01201610.1155/2016/89150478915047Rituximab-Associated Inflammatory Progressive Multifocal LeukoencephalopathyChandra Punch0Christina Schofield1Penelope Harris2Madigan Army Medical Center, Tacoma, WA, USAMadigan Army Medical Center, Tacoma, WA, USAMadigan Army Medical Center, Tacoma, WA, USAProgressive multifocal leukoencephalopathy (PML) is a rare disease of the immunosuppression that results from neurotropic invasion of the JC virus which leads to demyelination of oligodendrocytes. Immune reconstitution inflammatory syndrome (IRIS), on the other hand, is a condition of inflammation that develops as the immune system reconstitutes. This case report describes a case of a 35-year-old HIV-negative male who presented with three weeks of right lower extremity paresthesias as well as right upper extremity apraxia. He was diagnosed with PML complicated by IRIS secondary to Rituximab, which he had completed four months prior to presentation. Despite the condition’s poor prognosis, the patient recovered with only minor deficits.http://dx.doi.org/10.1155/2016/8915047 |
| spellingShingle | Chandra Punch Christina Schofield Penelope Harris Rituximab-Associated Inflammatory Progressive Multifocal Leukoencephalopathy Case Reports in Infectious Diseases |
| title | Rituximab-Associated Inflammatory Progressive Multifocal Leukoencephalopathy |
| title_full | Rituximab-Associated Inflammatory Progressive Multifocal Leukoencephalopathy |
| title_fullStr | Rituximab-Associated Inflammatory Progressive Multifocal Leukoencephalopathy |
| title_full_unstemmed | Rituximab-Associated Inflammatory Progressive Multifocal Leukoencephalopathy |
| title_short | Rituximab-Associated Inflammatory Progressive Multifocal Leukoencephalopathy |
| title_sort | rituximab associated inflammatory progressive multifocal leukoencephalopathy |
| url | http://dx.doi.org/10.1155/2016/8915047 |
| work_keys_str_mv | AT chandrapunch rituximabassociatedinflammatoryprogressivemultifocalleukoencephalopathy AT christinaschofield rituximabassociatedinflammatoryprogressivemultifocalleukoencephalopathy AT penelopeharris rituximabassociatedinflammatoryprogressivemultifocalleukoencephalopathy |