Lubiprostone Decreases the Small Bowel Transit Time by Capsule Endoscopy: An Exploratory, Randomised, Double-Blind, Placebo-Controlled 3-Way Crossover Study
The aim of this study was to investigate the usefulness of lubiprostone for bowel preparation and as a propulsive agent in small bowel endoscopy. Six healthy male volunteers participated in this randomized, 3-way crossover study. The subjects received a 24 μg tablet of lubiprostone 60 minutes prior...
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| Language: | English |
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Wiley
2014-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2014/879595 |
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| author | Mizue Matsuura Masahiko Inamori Hiroki Endo Tetsuya Matsuura Kenji Kanoshima Yumi Inoh Yuji Fujita Shotaro Umezawa Akiko Fuyuki Shiori Uchiyama Takuma Higurashi Hidenori Ohkubo Eiji Sakai Hiroshi Iida Takashi Nonaka Seiji Futagami Akihiko Kusakabe Shin Maeda Atsushi Nakajima |
| author_facet | Mizue Matsuura Masahiko Inamori Hiroki Endo Tetsuya Matsuura Kenji Kanoshima Yumi Inoh Yuji Fujita Shotaro Umezawa Akiko Fuyuki Shiori Uchiyama Takuma Higurashi Hidenori Ohkubo Eiji Sakai Hiroshi Iida Takashi Nonaka Seiji Futagami Akihiko Kusakabe Shin Maeda Atsushi Nakajima |
| author_sort | Mizue Matsuura |
| collection | DOAJ |
| description | The aim of this study was to investigate the usefulness of lubiprostone for bowel preparation and as a propulsive agent in small bowel endoscopy. Six healthy male volunteers participated in this randomized, 3-way crossover study. The subjects received a 24 μg tablet of lubiprostone 60 minutes prior to the capsule ingestion for capsule endoscopy (CE) and a placebo tablet 30 minutes before the capsule ingestion (L-P regimen), a placebo tablet 60 minutes prior to CE and a 24 μg tablet of lubiprostone 30 minutes prior to CE (P-L regimen), or a placebo tablet 60 minutes prior to r CE and a placebo tablet again 30 minutes prior to CE (P-P regimen). The quality of the capsule endoscopic images and the amount of water in the small bowel were assessed on 5-point scale. The median SBTT was 178.5 (117–407) minutes in the P-P regimen, 122.5 (27–282) minutes in the L-P regimen, and 110.5 (11–331) minutes in the P-L regimen (P=0.042). This study showed that the use of lubiprostone significantly decreased the SBTT. We also confirmed that lubiprostone was effective for inducing water secretion into the small bowel during CE. |
| format | Article |
| id | doaj-art-d33912ed1460441da4090124e8d2ed96 |
| institution | OA Journals |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-d33912ed1460441da4090124e8d2ed962025-08-20T02:19:51ZengWileyGastroenterology Research and Practice1687-61211687-630X2014-01-01201410.1155/2014/879595879595Lubiprostone Decreases the Small Bowel Transit Time by Capsule Endoscopy: An Exploratory, Randomised, Double-Blind, Placebo-Controlled 3-Way Crossover StudyMizue Matsuura0Masahiko Inamori1Hiroki Endo2Tetsuya Matsuura3Kenji Kanoshima4Yumi Inoh5Yuji Fujita6Shotaro Umezawa7Akiko Fuyuki8Shiori Uchiyama9Takuma Higurashi10Hidenori Ohkubo11Eiji Sakai12Hiroshi Iida13Takashi Nonaka14Seiji Futagami15Akihiko Kusakabe16Shin Maeda17Atsushi Nakajima18Hepatology and Gastroenterology, Yokohama City University Hospital, Kanagawa, Yokohama 236-0004, JapanOffice of Postgraduate Medical Education, Yokohama City University Hospital, 3-9 Fukuura, Kanazawa-ku, Kanagawa, Yokohama 236-0004, JapanHepatology and Gastroenterology, Yokohama City University Hospital, Kanagawa, Yokohama 236-0004, JapanHepatology and Gastroenterology, Yokohama City University Hospital, Kanagawa, Yokohama 236-0004, JapanHepatology and Gastroenterology, Yokohama City University Hospital, Kanagawa, Yokohama 236-0004, JapanHepatology and Gastroenterology, Yokohama City University Hospital, Kanagawa, Yokohama 236-0004, JapanHepatology and Gastroenterology, Yokohama City University Hospital, Kanagawa, Yokohama 236-0004, JapanHepatology and Gastroenterology, Yokohama City University Hospital, Kanagawa, Yokohama 236-0004, JapanHepatology and Gastroenterology, Yokohama City University Hospital, Kanagawa, Yokohama 236-0004, JapanHepatology and Gastroenterology, Yokohama City University Hospital, Kanagawa, Yokohama 236-0004, JapanHepatology and Gastroenterology, Yokohama City University Hospital, Kanagawa, Yokohama 236-0004, JapanHepatology and Gastroenterology, Yokohama City University Hospital, Kanagawa, Yokohama 236-0004, JapanHepatology and Gastroenterology, Yokohama City University Hospital, Kanagawa, Yokohama 236-0004, JapanHepatology and Gastroenterology, Yokohama City University Hospital, Kanagawa, Yokohama 236-0004, JapanHepatology and Gastroenterology, Yokohama City University Hospital, Kanagawa, Yokohama 236-0004, JapanDivision of Gastroenterology, Nippon Medical School, Tokyo 113-8603, JapanDepartment of General Medicine, Yokohama City University School of Medicine, Kanagawa, Yokohama 236-0004, JapanDepartment of Gastroenterology, Yokohama City University Hospital, Kanagawa, Yokohama 236-0004, JapanHepatology and Gastroenterology, Yokohama City University Hospital, Kanagawa, Yokohama 236-0004, JapanThe aim of this study was to investigate the usefulness of lubiprostone for bowel preparation and as a propulsive agent in small bowel endoscopy. Six healthy male volunteers participated in this randomized, 3-way crossover study. The subjects received a 24 μg tablet of lubiprostone 60 minutes prior to the capsule ingestion for capsule endoscopy (CE) and a placebo tablet 30 minutes before the capsule ingestion (L-P regimen), a placebo tablet 60 minutes prior to CE and a 24 μg tablet of lubiprostone 30 minutes prior to CE (P-L regimen), or a placebo tablet 60 minutes prior to r CE and a placebo tablet again 30 minutes prior to CE (P-P regimen). The quality of the capsule endoscopic images and the amount of water in the small bowel were assessed on 5-point scale. The median SBTT was 178.5 (117–407) minutes in the P-P regimen, 122.5 (27–282) minutes in the L-P regimen, and 110.5 (11–331) minutes in the P-L regimen (P=0.042). This study showed that the use of lubiprostone significantly decreased the SBTT. We also confirmed that lubiprostone was effective for inducing water secretion into the small bowel during CE.http://dx.doi.org/10.1155/2014/879595 |
| spellingShingle | Mizue Matsuura Masahiko Inamori Hiroki Endo Tetsuya Matsuura Kenji Kanoshima Yumi Inoh Yuji Fujita Shotaro Umezawa Akiko Fuyuki Shiori Uchiyama Takuma Higurashi Hidenori Ohkubo Eiji Sakai Hiroshi Iida Takashi Nonaka Seiji Futagami Akihiko Kusakabe Shin Maeda Atsushi Nakajima Lubiprostone Decreases the Small Bowel Transit Time by Capsule Endoscopy: An Exploratory, Randomised, Double-Blind, Placebo-Controlled 3-Way Crossover Study Gastroenterology Research and Practice |
| title | Lubiprostone Decreases the Small Bowel Transit Time by Capsule Endoscopy: An Exploratory, Randomised, Double-Blind, Placebo-Controlled 3-Way Crossover Study |
| title_full | Lubiprostone Decreases the Small Bowel Transit Time by Capsule Endoscopy: An Exploratory, Randomised, Double-Blind, Placebo-Controlled 3-Way Crossover Study |
| title_fullStr | Lubiprostone Decreases the Small Bowel Transit Time by Capsule Endoscopy: An Exploratory, Randomised, Double-Blind, Placebo-Controlled 3-Way Crossover Study |
| title_full_unstemmed | Lubiprostone Decreases the Small Bowel Transit Time by Capsule Endoscopy: An Exploratory, Randomised, Double-Blind, Placebo-Controlled 3-Way Crossover Study |
| title_short | Lubiprostone Decreases the Small Bowel Transit Time by Capsule Endoscopy: An Exploratory, Randomised, Double-Blind, Placebo-Controlled 3-Way Crossover Study |
| title_sort | lubiprostone decreases the small bowel transit time by capsule endoscopy an exploratory randomised double blind placebo controlled 3 way crossover study |
| url | http://dx.doi.org/10.1155/2014/879595 |
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