Pooling umbilical cord-mesenchymal stromal cells derived from selected multiple donors reduces donor-dependent variability and improves their immunomodulatory properties

Pooling umbilical cord-mesenchymal stromal cells derived from selected multiple donors reduces donor-dependent variability and improves their immunomodulatory properties

Abstract Background Umbilical Cord-derived Mesenchymal Stromal Cells (UC-MSCs) display high immunoregulatory properties, offering new perspectives to treat severe immune and inflammatory diseases. However, the heterogeneity of their biological properties remains a challenge to predict clinical respo...

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Bibliographic Details
Main Authors: Miryam Mebarki, Coralie Moine-Picard, Romain Enjaume-Rauch, Antoine Laurent-Puig, Annaelle Suissa, Valentine Feyants, Jérôme Larghero, Audrey Cras
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Stem Cell Research & Therapy
Subjects:
Human umbilical cord
Wharton’s jelly
Mesenchymal stromal cells
Immunomodulation
Donor heterogeneity
Donor variability
Online Access:https://doi.org/10.1186/s13287-025-04361-y
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