Revisiting polychlorinated biphenyls enriching in human and disrupting of thyroid hormone receptor β1
Polychlorinated biphenyls (PCBs) are persistent organic pollutants renowned for their bioaccumation and toxicity. Although PCBs production and use were banned worldwide decades ago, PCBs still pose a health risk due to their environmental persistence and unintentional production. In this report, PCB...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd.
2025-03-01
|
| Series: | Emerging Contaminants |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405665024001422 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849725304782716928 |
|---|---|
| author | Qiao Wang Junsong Bao Yuhao Fan Junjie Jiang Ying Wang Limei Chen Jun Jin |
| author_facet | Qiao Wang Junsong Bao Yuhao Fan Junjie Jiang Ying Wang Limei Chen Jun Jin |
| author_sort | Qiao Wang |
| collection | DOAJ |
| description | Polychlorinated biphenyls (PCBs) are persistent organic pollutants renowned for their bioaccumation and toxicity. Although PCBs production and use were banned worldwide decades ago, PCBs still pose a health risk due to their environmental persistence and unintentional production. In this report, PCB concentrations and temporal trends in serum from residents of urban areas in eastern China is investigated. The endocrine-disrupting potentials of PCBs are also investigated, particularly effects on thyroid hormone receptors. Through analysis of five years of data, results indicated that dioxin-like PCBs and congener PCB209 concentrations maintained low and had no marked temporal trends, but that the indicator PCBs and particularly PCB52, PCB153, and PCB180 concentrations increased. Furthermore, to evaluate binding of PCBs to the thyroid hormone receptor TRβ1, molecular docking simulations are performed. It is found that the PCBs of PCB28, PCB52, and PCB153 can interfere with triiodothyronine binding to TRβ1, which are comparable to the effects of the polybrominated biphenyl BB-153, a known thyroid function disruptor. What's more, the PCB180 binds to TRβ1 more strongly than that of BB-153. Our results indicated that a continuously monitoring of human exposures to PCB28, PCB52, PCB153, PCB180, and a detailed assessment of thyroid function interference is necessary. |
| format | Article |
| id | doaj-art-d3318f5cdae24a23a7aacb0af413e330 |
| institution | DOAJ |
| issn | 2405-6650 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Emerging Contaminants |
| spelling | doaj-art-d3318f5cdae24a23a7aacb0af413e3302025-08-20T03:10:30ZengKeAi Communications Co., Ltd.Emerging Contaminants2405-66502025-03-0111110044110.1016/j.emcon.2024.100441Revisiting polychlorinated biphenyls enriching in human and disrupting of thyroid hormone receptor β1Qiao Wang0Junsong Bao1Yuhao Fan2Junjie Jiang3Ying Wang4Limei Chen5Jun Jin6College of Life and Environmental Sciences, Minzu University of China, Beijing, 100081, ChinaState Key Laboratory of Water Environment Simulation, School of Environment, Beijing Normal University, Beijing 100875, ChinaCollege of Life and Environmental Sciences, Minzu University of China, Beijing, 100081, ChinaCollege of Life and Environmental Sciences, Minzu University of China, Beijing, 100081, ChinaCollege of Life and Environmental Sciences, Minzu University of China, Beijing, 100081, China; Engineering Research Center of Food Environment and Public Health, Beijing, 100081, ChinaThe Affiliated Wuxi Center for Disease Control and Prevention of Nanjing Medical University, Wuxi Center for Disease Control and Prevention, Wuxi Medical Center, Nanjing Medical University, Wuxi 214023, China; Corresponding author. The Affiliated Wuxi Center for Disease Control and Prevention of Nanjing Medical University, Wuxi Center for Disease Control and Prevention, Wuxi Medical Center, Nanjing Medical University, 499 Jincheng Road, Wuxi 214023, China.College of Life and Environmental Sciences, Minzu University of China, Beijing, 100081, China; Engineering Research Center of Food Environment and Public Health, Beijing, 100081, China; Corresponding author. College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, China.Polychlorinated biphenyls (PCBs) are persistent organic pollutants renowned for their bioaccumation and toxicity. Although PCBs production and use were banned worldwide decades ago, PCBs still pose a health risk due to their environmental persistence and unintentional production. In this report, PCB concentrations and temporal trends in serum from residents of urban areas in eastern China is investigated. The endocrine-disrupting potentials of PCBs are also investigated, particularly effects on thyroid hormone receptors. Through analysis of five years of data, results indicated that dioxin-like PCBs and congener PCB209 concentrations maintained low and had no marked temporal trends, but that the indicator PCBs and particularly PCB52, PCB153, and PCB180 concentrations increased. Furthermore, to evaluate binding of PCBs to the thyroid hormone receptor TRβ1, molecular docking simulations are performed. It is found that the PCBs of PCB28, PCB52, and PCB153 can interfere with triiodothyronine binding to TRβ1, which are comparable to the effects of the polybrominated biphenyl BB-153, a known thyroid function disruptor. What's more, the PCB180 binds to TRβ1 more strongly than that of BB-153. Our results indicated that a continuously monitoring of human exposures to PCB28, PCB52, PCB153, PCB180, and a detailed assessment of thyroid function interference is necessary.http://www.sciencedirect.com/science/article/pii/S2405665024001422Polychlorinated biphenyls (PCBs)Temporal trendsIndicator PCBsThyroid hormone receptorsEndocrine disruption |
| spellingShingle | Qiao Wang Junsong Bao Yuhao Fan Junjie Jiang Ying Wang Limei Chen Jun Jin Revisiting polychlorinated biphenyls enriching in human and disrupting of thyroid hormone receptor β1 Emerging Contaminants Polychlorinated biphenyls (PCBs) Temporal trends Indicator PCBs Thyroid hormone receptors Endocrine disruption |
| title | Revisiting polychlorinated biphenyls enriching in human and disrupting of thyroid hormone receptor β1 |
| title_full | Revisiting polychlorinated biphenyls enriching in human and disrupting of thyroid hormone receptor β1 |
| title_fullStr | Revisiting polychlorinated biphenyls enriching in human and disrupting of thyroid hormone receptor β1 |
| title_full_unstemmed | Revisiting polychlorinated biphenyls enriching in human and disrupting of thyroid hormone receptor β1 |
| title_short | Revisiting polychlorinated biphenyls enriching in human and disrupting of thyroid hormone receptor β1 |
| title_sort | revisiting polychlorinated biphenyls enriching in human and disrupting of thyroid hormone receptor β1 |
| topic | Polychlorinated biphenyls (PCBs) Temporal trends Indicator PCBs Thyroid hormone receptors Endocrine disruption |
| url | http://www.sciencedirect.com/science/article/pii/S2405665024001422 |
| work_keys_str_mv | AT qiaowang revisitingpolychlorinatedbiphenylsenrichinginhumananddisruptingofthyroidhormonereceptorb1 AT junsongbao revisitingpolychlorinatedbiphenylsenrichinginhumananddisruptingofthyroidhormonereceptorb1 AT yuhaofan revisitingpolychlorinatedbiphenylsenrichinginhumananddisruptingofthyroidhormonereceptorb1 AT junjiejiang revisitingpolychlorinatedbiphenylsenrichinginhumananddisruptingofthyroidhormonereceptorb1 AT yingwang revisitingpolychlorinatedbiphenylsenrichinginhumananddisruptingofthyroidhormonereceptorb1 AT limeichen revisitingpolychlorinatedbiphenylsenrichinginhumananddisruptingofthyroidhormonereceptorb1 AT junjin revisitingpolychlorinatedbiphenylsenrichinginhumananddisruptingofthyroidhormonereceptorb1 |