Association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and Sarcopenic obesity in U.S. adults: a cross-sectional study
Objective: This study examines the relationship between the ratio of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol (NHHR) and sarcopenic obesity in U.S. adults, utilizing data from the National Health and Nutrition Examination Survey (NHANES). Methods: We analysed...
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Elsevier
2025-08-01
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| Series: | Preventive Medicine Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211335525001901 |
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| author | Jiao Liu Fujue Ji Jong-Hee Kim |
| author_facet | Jiao Liu Fujue Ji Jong-Hee Kim |
| author_sort | Jiao Liu |
| collection | DOAJ |
| description | Objective: This study examines the relationship between the ratio of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol (NHHR) and sarcopenic obesity in U.S. adults, utilizing data from the National Health and Nutrition Examination Survey (NHANES). Methods: We analysed data from NHANES collected between 2011 and 2018. Multivariable regression models assessed the NHHR-sarcopenic obesity relationship, and limited cubic spline analysis investigated potential non-linearity. We employed likelihood ratio tests to evaluate model fit and performed subgroup analyses to verify the consistency of our findings. Results: The analysis included 8601 participants with an average age of 39.94 ± 11.45 years. In the fully adjusted model, each unit increase in NHHR was associated with a 76 % higher likelihood of sarcopenic obesity (odds ratio [OR]: 1.76, 95 % confidence interval [CI]: 1.18–2.63). The relationship between NHHR and sarcopenic obesity was non-linear, with a significant breakpoint at 3.36. Below this threshold, each unit increase in NHHR significantly increased the risk of sarcopenic obesity (OR: 1.53, 95 % CI: 1.32–1.78), while above this threshold, NHHR had no significant effect on sarcopenic obesity prevalence. Conclusions: These results indicate a positive and non-linear association between NHHR and sarcopenic obesity, suggesting that NHHR, as a simple and widely available lipid marker, may assist in the early identification of individuals at risk of sarcopenic obesity. Further large-scale longitudinal studies are needed to validate its predictive value across broader age groups and to clarify its potential utility in personalized risk assessment and clinical screening. |
| format | Article |
| id | doaj-art-d33030eabb734fc5bda514240fa5713d |
| institution | Kabale University |
| issn | 2211-3355 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
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| series | Preventive Medicine Reports |
| spelling | doaj-art-d33030eabb734fc5bda514240fa5713d2025-08-20T03:50:58ZengElsevierPreventive Medicine Reports2211-33552025-08-015610315110.1016/j.pmedr.2025.103151Association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and Sarcopenic obesity in U.S. adults: a cross-sectional studyJiao Liu0Fujue Ji1Jong-Hee Kim2Major in Sport Science, Division of Sport Industry and Science, College of Performing Arts and Sport, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul, Republic of KoreaMajor in Sport Science, Division of Sport Industry and Science, College of Performing Arts and Sport, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul, Republic of Korea; BK21 FOUR Human-Tech Convergence Program, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, 004763, Republic of KoreaMajor in Sport Science, Division of Sport Industry and Science, College of Performing Arts and Sport, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul, Republic of Korea; BK21 FOUR Human-Tech Convergence Program, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, 004763, Republic of Korea; Corresponding author at: Major in Sport Science, Division of Sport Industry and Science, College of Performing Arts and Sport, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul, Republic of Korea.Objective: This study examines the relationship between the ratio of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol (NHHR) and sarcopenic obesity in U.S. adults, utilizing data from the National Health and Nutrition Examination Survey (NHANES). Methods: We analysed data from NHANES collected between 2011 and 2018. Multivariable regression models assessed the NHHR-sarcopenic obesity relationship, and limited cubic spline analysis investigated potential non-linearity. We employed likelihood ratio tests to evaluate model fit and performed subgroup analyses to verify the consistency of our findings. Results: The analysis included 8601 participants with an average age of 39.94 ± 11.45 years. In the fully adjusted model, each unit increase in NHHR was associated with a 76 % higher likelihood of sarcopenic obesity (odds ratio [OR]: 1.76, 95 % confidence interval [CI]: 1.18–2.63). The relationship between NHHR and sarcopenic obesity was non-linear, with a significant breakpoint at 3.36. Below this threshold, each unit increase in NHHR significantly increased the risk of sarcopenic obesity (OR: 1.53, 95 % CI: 1.32–1.78), while above this threshold, NHHR had no significant effect on sarcopenic obesity prevalence. Conclusions: These results indicate a positive and non-linear association between NHHR and sarcopenic obesity, suggesting that NHHR, as a simple and widely available lipid marker, may assist in the early identification of individuals at risk of sarcopenic obesity. Further large-scale longitudinal studies are needed to validate its predictive value across broader age groups and to clarify its potential utility in personalized risk assessment and clinical screening.http://www.sciencedirect.com/science/article/pii/S2211335525001901Cross-sectional researchSarcopenic obesitySerum lipidsNon-high-density lipoprotein cholesterolHigh-density lipoprotein cholesterol |
| spellingShingle | Jiao Liu Fujue Ji Jong-Hee Kim Association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and Sarcopenic obesity in U.S. adults: a cross-sectional study Preventive Medicine Reports Cross-sectional research Sarcopenic obesity Serum lipids Non-high-density lipoprotein cholesterol High-density lipoprotein cholesterol |
| title | Association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and Sarcopenic obesity in U.S. adults: a cross-sectional study |
| title_full | Association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and Sarcopenic obesity in U.S. adults: a cross-sectional study |
| title_fullStr | Association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and Sarcopenic obesity in U.S. adults: a cross-sectional study |
| title_full_unstemmed | Association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and Sarcopenic obesity in U.S. adults: a cross-sectional study |
| title_short | Association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and Sarcopenic obesity in U.S. adults: a cross-sectional study |
| title_sort | association between the non high density lipoprotein cholesterol to high density lipoprotein cholesterol ratio and sarcopenic obesity in u s adults a cross sectional study |
| topic | Cross-sectional research Sarcopenic obesity Serum lipids Non-high-density lipoprotein cholesterol High-density lipoprotein cholesterol |
| url | http://www.sciencedirect.com/science/article/pii/S2211335525001901 |
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