MIL-101 (Cr): synthesis and simultaneous electrochemical determination of uric acid and theophylline using MIL-101 (Cr) modified electrode

MIL-101 (Cr): synthesis and simultaneous electrochemical determination of uric acid and theophylline using MIL-101 (Cr) modified electrode

This paper uses hydrothermal processes to synthesize metal–organic frameworks in the MIL (Materials Institute Lavoisier) series. Our research revealed that MIL-101 was formed at the early synthetic stage, approximately eight hours, followed by the formation of MIL-88B with further prolongation of th...

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Main Authors: Nguyen Ngoc Nghia, Nguyen Quang Man, Hoa Thi Le, Nguyen Duc Vu Quyen, Ho Van Minh Hai, Nguyen Chi Bao, Son Van Thanh Le, Trinh Ngoc Dat, Le Thi Hong Phong, Vo Thi Khanh Ly, Nguyen Dinh Luyen, Dinh Quang Khieu
Format: Article
Language:English
Published: IOP Publishing 2025-01-01
Series:Materials Research Express
Subjects:
uric acid
theophylline
MIL-88B
MIL-101
Online Access:https://doi.org/10.1088/2053-1591/adfad2
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Summary:This paper uses hydrothermal processes to synthesize metal–organic frameworks in the MIL (Materials Institute Lavoisier) series. Our research revealed that MIL-101 was formed at the early synthetic stage, approximately eight hours, followed by the formation of MIL-88B with further prolongation of the hydrothermal time. The morphology of the octahedral shape for MIL-101 transformed into the rod-like shape of MIL-88B, accompanied by a decrease in the surface area. The electrode modified by MIL-101 exhibited electrochemical activity towards uric acid and theophylline better than that modified by MIL-88B. We also developed a glassy carbon electrode (GCE) modified by MIL-101 for simultaneous uric acid and theophylline detection. Electrochemical sensing features were investigated using electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV), and differential pulse voltammetry (DPV). The calibration curves for uric acid and theophylline were obtained in the 0.20–1.69 μM range. The detection limits (3 σ ) were 0.12 μM and 0.13 μM for uric acid and theophylline, respectively. Notably, using a standard addition method, the present approach was used to determine URI and THE in urine samples, achieving exceptional recoveries. The proposed electrochemical sensor also revealed good reproducibility, repeatability, and long-term stability.
ISSN:2053-1591

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