Inhibition of lethal inflammatory responses through the targeting of membrane‐associated Toll‐like receptor 4 signaling complexes with a Smad6‐derived peptide

Inhibition of lethal inflammatory responses through the targeting of membrane‐associated Toll‐like receptor 4 signaling complexes with a Smad6‐derived peptide

Abstract We have previously reported that Smad6, one of the inhibitory Smads of transforming growth factor‐β (TGF‐β)/bone morphogenetic protein (BMP) signaling, inhibits Toll‐like receptor (TLR) 4 signaling by disrupting the Pellino‐1‐mediated TLR4 signaling complex. Here, we developed Smaducin‐6, a...

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Main Authors: Youn Sook Lee, Jin Seok Park, Su Myung Jung, Sang‐Doo Kim, Jun Hwan Kim, Jae Young Lee, Kyeong Cheon Jung, Mizuko Mamura, Sangho Lee, Seong‐Jin Kim, Yoe‐Sik Bae, Seok Hee Park
Format: Article
Language:English
Published: Springer Nature 2015-03-01
Series:EMBO Molecular Medicine
Subjects:
inflammation
Pellino‐1
sepsis
Smad6
TLR4
Online Access:https://doi.org/10.15252/emmm.201404653
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