Phenomenological and mechanistic insights into potential dietary nucleotide – probiotic synergies in layer chickens: A review
Despite their growing popularity as alternatives to antibiotic growth promoters (AGPs), the individual effects of nucleotides and probiotics on poultry gut functionality remain poorly understood. In addition, inconsistent outcomes are quite common in studies where these two additives have been used...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-05-01
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| Series: | Poultry Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0032579125002883 |
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| author | Siphosethu R. Dibakoane Godfrey Mhlongo Ghaneshree Moonsamy Obiro Cuthbert Wokadala Caven Mguvane Mnisi Victor Mlambo |
| author_facet | Siphosethu R. Dibakoane Godfrey Mhlongo Ghaneshree Moonsamy Obiro Cuthbert Wokadala Caven Mguvane Mnisi Victor Mlambo |
| author_sort | Siphosethu R. Dibakoane |
| collection | DOAJ |
| description | Despite their growing popularity as alternatives to antibiotic growth promoters (AGPs), the individual effects of nucleotides and probiotics on poultry gut functionality remain poorly understood. In addition, inconsistent outcomes are quite common in studies where these two additives have been used separately to modify gut function and related parameters in birds. These inconsistencies, which have limited the potential of probiotics and nucleotides as AGP replacements, stem from various factors and need to be addressed. Combining probiotics and nucleotides could potentially enhance their effectiveness and lead to more consistent outcomes in layer chickens. Since their mechanisms of action complement each other, some level of synergy is expected when used together. Both additives have been shown to support gut health, boost immune function, and improve performance in chickens when used individually. However, no studies have investigated the possible synergistic effects of nucleotides and probiotics in poultry. This review makes the case for combined use of probiotics and nucleotides in layer chickens by providing phenomenological and mechanistic insights into hypothetical synergistic effects. This paper highlights the need for AGP alternatives and reviews studies on the effects and mechanisms of probiotics and nucleotides in layer chickens when used individually. We then propose potential mechanisms for their synergistic effects on gut health, performance, and egg quality based on logical deductions from observed biological responses. These proposed mechanisms are hypothetical and require experimental validation. Finally, the review explores how this synergy could lead to more consistent outcomes and enhance the feasibility of AGP-free egg production. |
| format | Article |
| id | doaj-art-d317530562f94b6ca2f560d8b754ec70 |
| institution | OA Journals |
| issn | 0032-5791 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Poultry Science |
| spelling | doaj-art-d317530562f94b6ca2f560d8b754ec702025-08-20T02:31:00ZengElsevierPoultry Science0032-57912025-05-01104510504910.1016/j.psj.2025.105049Phenomenological and mechanistic insights into potential dietary nucleotide – probiotic synergies in layer chickens: A reviewSiphosethu R. Dibakoane0Godfrey Mhlongo1Ghaneshree Moonsamy2Obiro Cuthbert Wokadala3Caven Mguvane Mnisi4Victor Mlambo5School of Agricultural Sciences, Faculty of Agriculture and Natural Sciences, University of Mpumalanga, Nelspruit 1200, South AfricaSchool of Agricultural Sciences, Faculty of Agriculture and Natural Sciences, University of Mpumalanga, Nelspruit 1200, South AfricaCouncil for Scientific and Industrial Research (CSIR); Future production: Chemicals, Meiring Naude Drive, Pretoria 0081, South AfricaSchool of Agricultural Sciences, Faculty of Agriculture and Natural Sciences, University of Mpumalanga, Nelspruit 1200, South AfricaDepartment of Animal Science, Faculty of Natural and Agricultural Sciences, North-West University, Mafikeng 2735, South Africa; Food Security and Safety Focus Area, Faculty of Natural and Agricultural Sciences, North-West University, Mafikeng 2735, South AfricaSchool of Agricultural Sciences, Faculty of Agriculture and Natural Sciences, University of Mpumalanga, Nelspruit 1200, South Africa; Corresponding author.Despite their growing popularity as alternatives to antibiotic growth promoters (AGPs), the individual effects of nucleotides and probiotics on poultry gut functionality remain poorly understood. In addition, inconsistent outcomes are quite common in studies where these two additives have been used separately to modify gut function and related parameters in birds. These inconsistencies, which have limited the potential of probiotics and nucleotides as AGP replacements, stem from various factors and need to be addressed. Combining probiotics and nucleotides could potentially enhance their effectiveness and lead to more consistent outcomes in layer chickens. Since their mechanisms of action complement each other, some level of synergy is expected when used together. Both additives have been shown to support gut health, boost immune function, and improve performance in chickens when used individually. However, no studies have investigated the possible synergistic effects of nucleotides and probiotics in poultry. This review makes the case for combined use of probiotics and nucleotides in layer chickens by providing phenomenological and mechanistic insights into hypothetical synergistic effects. This paper highlights the need for AGP alternatives and reviews studies on the effects and mechanisms of probiotics and nucleotides in layer chickens when used individually. We then propose potential mechanisms for their synergistic effects on gut health, performance, and egg quality based on logical deductions from observed biological responses. These proposed mechanisms are hypothetical and require experimental validation. Finally, the review explores how this synergy could lead to more consistent outcomes and enhance the feasibility of AGP-free egg production.http://www.sciencedirect.com/science/article/pii/S0032579125002883Gut functionProbioticSynergismEgg qualityDietary nucleotide |
| spellingShingle | Siphosethu R. Dibakoane Godfrey Mhlongo Ghaneshree Moonsamy Obiro Cuthbert Wokadala Caven Mguvane Mnisi Victor Mlambo Phenomenological and mechanistic insights into potential dietary nucleotide – probiotic synergies in layer chickens: A review Poultry Science Gut function Probiotic Synergism Egg quality Dietary nucleotide |
| title | Phenomenological and mechanistic insights into potential dietary nucleotide – probiotic synergies in layer chickens: A review |
| title_full | Phenomenological and mechanistic insights into potential dietary nucleotide – probiotic synergies in layer chickens: A review |
| title_fullStr | Phenomenological and mechanistic insights into potential dietary nucleotide – probiotic synergies in layer chickens: A review |
| title_full_unstemmed | Phenomenological and mechanistic insights into potential dietary nucleotide – probiotic synergies in layer chickens: A review |
| title_short | Phenomenological and mechanistic insights into potential dietary nucleotide – probiotic synergies in layer chickens: A review |
| title_sort | phenomenological and mechanistic insights into potential dietary nucleotide probiotic synergies in layer chickens a review |
| topic | Gut function Probiotic Synergism Egg quality Dietary nucleotide |
| url | http://www.sciencedirect.com/science/article/pii/S0032579125002883 |
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