Sculptors of cerebellar fissures and their potential as therapeutic targets for cerebellar dysfunction
The cerebellum plays an important role in both motor control and cognition. The cerebellar cortex is neuron-rich and composed of characteristic folia and fissures. Defective cerebellar development leads to movement disorders and developmental delay. During early morphogenesis, cellular signaling pro...
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| Format: | Article |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Cellular Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2025.1608185/full |
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| author | Chiu-Lun Shen Yu-Young Tsai Woan-Yuh Tarn |
| author_facet | Chiu-Lun Shen Yu-Young Tsai Woan-Yuh Tarn |
| author_sort | Chiu-Lun Shen |
| collection | DOAJ |
| description | The cerebellum plays an important role in both motor control and cognition. The cerebellar cortex is neuron-rich and composed of characteristic folia and fissures. Defective cerebellar development leads to movement disorders and developmental delay. During early morphogenesis, cellular signaling programs orchestrate simultaneous cerebellar growth and foliation. Aberrant signaling causes various degrees of cerebellar hypoplasia. Based on mouse genetic studies, we discuss several developmental signaling pathways that drive cerebellar morphogenesis. Notably, hypoplasia of vermal lobules VI-VII has been linked to autism spectrum disorder and is in part attributed to brain-derived neurotrophic factor (BDNF)/tropomyosin receptor kinase B signaling. This review also discusses how BDNF biogenesis is critical for cerebellar foliation and whether restoring BDNF signaling could reverse cerebellar developmental disorders. |
| format | Article |
| id | doaj-art-d315c058c06f4a3abeb95aca28c7a055 |
| institution | Kabale University |
| issn | 1662-5102 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj-art-d315c058c06f4a3abeb95aca28c7a0552025-08-20T03:24:52ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022025-06-011910.3389/fncel.2025.16081851608185Sculptors of cerebellar fissures and their potential as therapeutic targets for cerebellar dysfunctionChiu-Lun Shen0Yu-Young Tsai1Woan-Yuh Tarn2Institute of Biomedical Sciences, Academia Sinica, Taipei, TaiwanDepartment of Biological Sciences, Columbia University in the City of New York, New York, NY, United StatesInstitute of Biomedical Sciences, Academia Sinica, Taipei, TaiwanThe cerebellum plays an important role in both motor control and cognition. The cerebellar cortex is neuron-rich and composed of characteristic folia and fissures. Defective cerebellar development leads to movement disorders and developmental delay. During early morphogenesis, cellular signaling programs orchestrate simultaneous cerebellar growth and foliation. Aberrant signaling causes various degrees of cerebellar hypoplasia. Based on mouse genetic studies, we discuss several developmental signaling pathways that drive cerebellar morphogenesis. Notably, hypoplasia of vermal lobules VI-VII has been linked to autism spectrum disorder and is in part attributed to brain-derived neurotrophic factor (BDNF)/tropomyosin receptor kinase B signaling. This review also discusses how BDNF biogenesis is critical for cerebellar foliation and whether restoring BDNF signaling could reverse cerebellar developmental disorders.https://www.frontiersin.org/articles/10.3389/fncel.2025.1608185/fullcerebellar foliationcerebellar fissurecerebellar disorderdevelopmental signalingBDNF |
| spellingShingle | Chiu-Lun Shen Yu-Young Tsai Woan-Yuh Tarn Sculptors of cerebellar fissures and their potential as therapeutic targets for cerebellar dysfunction Frontiers in Cellular Neuroscience cerebellar foliation cerebellar fissure cerebellar disorder developmental signaling BDNF |
| title | Sculptors of cerebellar fissures and their potential as therapeutic targets for cerebellar dysfunction |
| title_full | Sculptors of cerebellar fissures and their potential as therapeutic targets for cerebellar dysfunction |
| title_fullStr | Sculptors of cerebellar fissures and their potential as therapeutic targets for cerebellar dysfunction |
| title_full_unstemmed | Sculptors of cerebellar fissures and their potential as therapeutic targets for cerebellar dysfunction |
| title_short | Sculptors of cerebellar fissures and their potential as therapeutic targets for cerebellar dysfunction |
| title_sort | sculptors of cerebellar fissures and their potential as therapeutic targets for cerebellar dysfunction |
| topic | cerebellar foliation cerebellar fissure cerebellar disorder developmental signaling BDNF |
| url | https://www.frontiersin.org/articles/10.3389/fncel.2025.1608185/full |
| work_keys_str_mv | AT chiulunshen sculptorsofcerebellarfissuresandtheirpotentialastherapeutictargetsforcerebellardysfunction AT yuyoungtsai sculptorsofcerebellarfissuresandtheirpotentialastherapeutictargetsforcerebellardysfunction AT woanyuhtarn sculptorsofcerebellarfissuresandtheirpotentialastherapeutictargetsforcerebellardysfunction |