Berberine Suppresses Influenza A Virus-Triggered Pyroptosis in Macrophages via Intervening in the mtROS-MAVS-NLRP3 Inflammasome Pathway

Berberine Suppresses Influenza A Virus-Triggered Pyroptosis in Macrophages via Intervening in the mtROS-MAVS-NLRP3 Inflammasome Pathway

Infection with influenza A virus (IAV) may trigger excessive inflammatory responses, leading to severe viral pneumonia and accelerating disease progression. Therefore, controlling these excessive inflammatory responses is crucial for the prevention and treatment of pneumonia caused by IAV. Berberine...

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Bibliographic Details
Main Authors: Mengfan Zhao, Di Deng, Hui Liu, Rui Guo, Jun Wu, Yu Hao, Mingrui Yang
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Viruses
Subjects:
influenza A virus (IAV)
macrophage pyroptosis
berberine (BBR)
anti-inflammatory
mitochondrial antiviral signaling protein (MAVS)
Online Access:https://www.mdpi.com/1999-4915/17/4/539
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