Predicting response to benralizumab in patients with COPD: a plain language summary of publication of the GALATHEA and TERRANOVA studies

Summary What is this summary about? ● This is a plain language summary of two articles originally published in The New England Journal of Medicine and The Lancet Respiratory Medicine . These articles presented the results of GALATHEA and TERRANOVA, two clinical studies that took place across 41 coun...

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Main Authors: Gerard J. Criner, Dave Singh, Alberto Papi, Maria Jison, Natalya Makulova, Vivian H. Shih, Laura Brooks, Peter N. Barker, Ubaldo J. Martin
Format: Article
Language:English
Published: SAGE Publishing 2025-03-01
Series:Therapeutic Advances in Respiratory Disease
Online Access:https://doi.org/10.1177/17534666241312060
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Summary:Summary What is this summary about? ● This is a plain language summary of two articles originally published in The New England Journal of Medicine and The Lancet Respiratory Medicine . These articles presented the results of GALATHEA and TERRANOVA, two clinical studies that took place across 41 countries.  ○ GALATHEA and TERRANOVA measured how patients’ COPD changed from before their first benralizumab (10, 30, or 100 mg) injection, to after 56 weeks of treatment.  ○ In both studies, benralizumab was compared with placebo .  ○ To see whether benralizumab treatment would benefit any particular patients included in these studies, researchers carried out an additional analysis following the main studies of GALATHEA and TERRANOVA.
ISSN:1753-4666