The underappreciated contribution of Oskar Fischer to the knowledge of Frontotemporal Lobar Degeneration
ABSTRACT Frontotemporal Lobar Degeneration (FTLD) encompasses progressive neurodegeneration primarily affecting the frontal and/or temporal lobes, presenting in varied pathological entities. These pathologies lead to diverse clinical syndromes collectively known as Frontotemporal Dementia (FTD), whi...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Associação Neurologia Cognitiva e do Comportamento
2025-02-01
|
| Series: | Dementia & Neuropsychologia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642025000100900&lng=en&tlng=en |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823859137098809344 |
|---|---|
| author | Eliasz Engelhardt Lea Tenenholz Grinberg |
| author_facet | Eliasz Engelhardt Lea Tenenholz Grinberg |
| author_sort | Eliasz Engelhardt |
| collection | DOAJ |
| description | ABSTRACT Frontotemporal Lobar Degeneration (FTLD) encompasses progressive neurodegeneration primarily affecting the frontal and/or temporal lobes, presenting in varied pathological entities. These pathologies lead to diverse clinical syndromes collectively known as Frontotemporal Dementia (FTD), which includes a behavioral variant, and primary progressive aphasia, with its non-fluent and semantic variants, and related conditions with parkinsonism or motoneuron disease features. The historical development of FTD concept is rooted in the pioneering work of Arnold Pick, who first described clinical cases of focal brain atrophy. Oskar Fischer significantly advanced this field by detailing the histopathological features of these conditions, such as the ‘spongiform cortical wasting’, and identifying characteristic neuronal changes such as the ‘ballooned cells’. Fischer’s contributions, alongside those of contemporaries like Alois Alzheimer, laid the foundation for understanding FTLD histopathology. Here, Fischer’s overlooked work is spotlighted, advocating for a greater recognition, which he rightfully deserves for his contributions to the field of neurodegenerative diseases. |
| format | Article |
| id | doaj-art-d3115b40b5d143e5a450d7b4d5ba18c1 |
| institution | Kabale University |
| issn | 1980-5764 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Associação Neurologia Cognitiva e do Comportamento |
| record_format | Article |
| series | Dementia & Neuropsychologia |
| spelling | doaj-art-d3115b40b5d143e5a450d7b4d5ba18c12025-02-11T07:43:34ZengAssociação Neurologia Cognitiva e do ComportamentoDementia & Neuropsychologia1980-57642025-02-011910.1590/1980-5764-dn-2024-0226The underappreciated contribution of Oskar Fischer to the knowledge of Frontotemporal Lobar DegenerationEliasz Engelhardthttps://orcid.org/0000-0003-4168-1992Lea Tenenholz Grinberghttps://orcid.org/0000-0002-6809-0618ABSTRACT Frontotemporal Lobar Degeneration (FTLD) encompasses progressive neurodegeneration primarily affecting the frontal and/or temporal lobes, presenting in varied pathological entities. These pathologies lead to diverse clinical syndromes collectively known as Frontotemporal Dementia (FTD), which includes a behavioral variant, and primary progressive aphasia, with its non-fluent and semantic variants, and related conditions with parkinsonism or motoneuron disease features. The historical development of FTD concept is rooted in the pioneering work of Arnold Pick, who first described clinical cases of focal brain atrophy. Oskar Fischer significantly advanced this field by detailing the histopathological features of these conditions, such as the ‘spongiform cortical wasting’, and identifying characteristic neuronal changes such as the ‘ballooned cells’. Fischer’s contributions, alongside those of contemporaries like Alois Alzheimer, laid the foundation for understanding FTLD histopathology. Here, Fischer’s overlooked work is spotlighted, advocating for a greater recognition, which he rightfully deserves for his contributions to the field of neurodegenerative diseases.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642025000100900&lng=en&tlng=enFrontotemporal Lobar DegenerationOskar FischerNeurodegenerative DiseasesPick’s Disease |
| spellingShingle | Eliasz Engelhardt Lea Tenenholz Grinberg The underappreciated contribution of Oskar Fischer to the knowledge of Frontotemporal Lobar Degeneration Dementia & Neuropsychologia Frontotemporal Lobar Degeneration Oskar Fischer Neurodegenerative Diseases Pick’s Disease |
| title | The underappreciated contribution of Oskar Fischer to the knowledge of Frontotemporal Lobar Degeneration |
| title_full | The underappreciated contribution of Oskar Fischer to the knowledge of Frontotemporal Lobar Degeneration |
| title_fullStr | The underappreciated contribution of Oskar Fischer to the knowledge of Frontotemporal Lobar Degeneration |
| title_full_unstemmed | The underappreciated contribution of Oskar Fischer to the knowledge of Frontotemporal Lobar Degeneration |
| title_short | The underappreciated contribution of Oskar Fischer to the knowledge of Frontotemporal Lobar Degeneration |
| title_sort | underappreciated contribution of oskar fischer to the knowledge of frontotemporal lobar degeneration |
| topic | Frontotemporal Lobar Degeneration Oskar Fischer Neurodegenerative Diseases Pick’s Disease |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642025000100900&lng=en&tlng=en |
| work_keys_str_mv | AT eliaszengelhardt theunderappreciatedcontributionofoskarfischertotheknowledgeoffrontotemporallobardegeneration AT leatenenholzgrinberg theunderappreciatedcontributionofoskarfischertotheknowledgeoffrontotemporallobardegeneration AT eliaszengelhardt underappreciatedcontributionofoskarfischertotheknowledgeoffrontotemporallobardegeneration AT leatenenholzgrinberg underappreciatedcontributionofoskarfischertotheknowledgeoffrontotemporallobardegeneration |