Can Passive Cough Monitoring Predict COPD Exacerbations?
Purpose Validation of an alert mechanism for COPD exacerbations based on coughing detected by a stationary unobtrusive nighttime monitor.Methods This prospective double-blind longitudinal study of cough monitoring included 40 chronic obstructive pulmonary disease (COPD) patients. Participants underw...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-04-01
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| Series: | COPD |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/15412555.2025.2487909 |
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| author | A. H. Morice A. C. den Brinker M. Crooks S. Thackray-Nocera O. Ouweltjes R. Rietman |
| author_facet | A. H. Morice A. C. den Brinker M. Crooks S. Thackray-Nocera O. Ouweltjes R. Rietman |
| author_sort | A. H. Morice |
| collection | DOAJ |
| description | Purpose Validation of an alert mechanism for COPD exacerbations based on coughing detected by a stationary unobtrusive nighttime monitor.Methods This prospective double-blind longitudinal study of cough monitoring included 40 chronic obstructive pulmonary disease (COPD) patients. Participants underwent cough monitoring and completed a daily questionnaire for 12 weeks. If no exacerbation occurred within that period patients were asked to continue being monitored for a further 12 weeks. The automated system identified deteriorating trends in cough based on a personalized cough classifier and the alerts were compared with patient reported exacerbation onsets.Results Thirty-eight patients [median age 72 (range 57–84)], median FEV-1% predicted 43% (range 20–106%) completed the study and had 41 exacerbations over a total of 3981 days. For 32 patients, the cough monitor data allowed classifier personalization, trend analysis, and alert generation. Based on the trend data, it is estimated that ∼30% of exacerbations are not associated with an increase in cough. The alert mechanism flagged 59% of the exacerbations. For the cases with alerts preceding the onset, the associated lead time was 4 days or more.Conclusion Though based on a single variable only, the cough-based alert system captured more than half of the exacerbations in a passive, free-living scenario. No adherence issues were reported, and patients confirmed the unobtrusive and hassle-free nature of the approach. |
| format | Article |
| id | doaj-art-d30da4032a724b1e9a43ee663742a8b3 |
| institution | DOAJ |
| issn | 1541-2555 1541-2563 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | COPD |
| spelling | doaj-art-d30da4032a724b1e9a43ee663742a8b32025-08-20T03:06:44ZengTaylor & Francis GroupCOPD1541-25551541-25632025-04-0122110.1080/15412555.2025.2487909Can Passive Cough Monitoring Predict COPD Exacerbations?A. H. Morice0A. C. den Brinker1M. Crooks2S. Thackray-Nocera3O. Ouweltjes4R. Rietman5Department of Academic Respiratory Medicine, Centre for Cardiovascular and Metabolic Research, Hull York Medical School, Castle Hill Hospital, Hull, UKIndependent Researcher, Formerly with Philips Research, High Tech Campus, Eindhoven, NetherlandsDepartment of Academic Respiratory Medicine, Centre for Cardiovascular and Metabolic Research, Hull York Medical School, Castle Hill Hospital, Hull, UKDepartment of Academic Respiratory Medicine, Centre for Cardiovascular and Metabolic Research, Hull York Medical School, Castle Hill Hospital, Hull, UKDigital Standardization & Licensing Research, Philips, High Tech Campus, Eindhoven, NetherlandsInnovation Engineering, Data Science and AI, Philips, High Tech Campus, Eindhoven, NetherlandsPurpose Validation of an alert mechanism for COPD exacerbations based on coughing detected by a stationary unobtrusive nighttime monitor.Methods This prospective double-blind longitudinal study of cough monitoring included 40 chronic obstructive pulmonary disease (COPD) patients. Participants underwent cough monitoring and completed a daily questionnaire for 12 weeks. If no exacerbation occurred within that period patients were asked to continue being monitored for a further 12 weeks. The automated system identified deteriorating trends in cough based on a personalized cough classifier and the alerts were compared with patient reported exacerbation onsets.Results Thirty-eight patients [median age 72 (range 57–84)], median FEV-1% predicted 43% (range 20–106%) completed the study and had 41 exacerbations over a total of 3981 days. For 32 patients, the cough monitor data allowed classifier personalization, trend analysis, and alert generation. Based on the trend data, it is estimated that ∼30% of exacerbations are not associated with an increase in cough. The alert mechanism flagged 59% of the exacerbations. For the cases with alerts preceding the onset, the associated lead time was 4 days or more.Conclusion Though based on a single variable only, the cough-based alert system captured more than half of the exacerbations in a passive, free-living scenario. No adherence issues were reported, and patients confirmed the unobtrusive and hassle-free nature of the approach.https://www.tandfonline.com/doi/10.1080/15412555.2025.2487909COPDexacerbationalert systemautomated cough counttelehealth |
| spellingShingle | A. H. Morice A. C. den Brinker M. Crooks S. Thackray-Nocera O. Ouweltjes R. Rietman Can Passive Cough Monitoring Predict COPD Exacerbations? COPD COPD exacerbation alert system automated cough count telehealth |
| title | Can Passive Cough Monitoring Predict COPD Exacerbations? |
| title_full | Can Passive Cough Monitoring Predict COPD Exacerbations? |
| title_fullStr | Can Passive Cough Monitoring Predict COPD Exacerbations? |
| title_full_unstemmed | Can Passive Cough Monitoring Predict COPD Exacerbations? |
| title_short | Can Passive Cough Monitoring Predict COPD Exacerbations? |
| title_sort | can passive cough monitoring predict copd exacerbations |
| topic | COPD exacerbation alert system automated cough count telehealth |
| url | https://www.tandfonline.com/doi/10.1080/15412555.2025.2487909 |
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