Cardiovascular disease risk prediction by Framingham risk score in women with polycystic ovary syndrome
Abstract Background Despite the documented increased cardiovascular disease (CVD) risk in women with polycystic ovary syndrome (PCOS), no specific risk prediction tools are recommended for these patients. We aimed to assess the validity of the Framingham Risk Score (FRS) as a predictor of CVD risk i...
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BMC
2025-02-01
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| Series: | Reproductive Biology and Endocrinology |
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| Online Access: | https://doi.org/10.1186/s12958-025-01346-7 |
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| author | Mina Amiri Maryam Mousavi Mahsa Noroozzadeh Fereidoun Azizi Fahimeh Ramezani Tehrani |
| author_facet | Mina Amiri Maryam Mousavi Mahsa Noroozzadeh Fereidoun Azizi Fahimeh Ramezani Tehrani |
| author_sort | Mina Amiri |
| collection | DOAJ |
| description | Abstract Background Despite the documented increased cardiovascular disease (CVD) risk in women with polycystic ovary syndrome (PCOS), no specific risk prediction tools are recommended for these patients. We aimed to assess the validity of the Framingham Risk Score (FRS) as a predictor of CVD risk in PCOS patients. Methods In a community-based prospective study, 4,435 women from the Tehran Lipid and Glucose Study (TLGS) cohort were analyzed. Among them, 215 women aged 30 years or older were diagnosed with PCOS. A Cox proportional hazards model applied to assess the relationship between the FRS and CVD event. Model accuracy was evaluated using the C-statistic, while discrimination and calibration were assessed via the ROC curve, area under the ROC curve (AUC) statistics, and the Hosmer- Lemeshow test. Results The Cox proportional hazards (HRs) model revealed that the CVD risk increased by 38% for each one-unit increase in the FRS [HR: 1.38 (95% CI: 1.14, 1.66)] in PCOS patients. The FRS had a C-statistic of 0.765, which indicated a satisfactory fit for CVD prediction in this population. The AUC of the ROC curve was 0.82, which demonstrated a good discrimination of the FRS. The Hosmer-Lemeshow test showed that the predicted probabilities of CVD were consistent with the observed CVD rates (p = 0.217), indicating a good calibration. Conclusions This study revealed a significant increase in CVD risk among PCOS patients. The FRS effectively predicts a 38% increment in CVD risk for every one-unit increase in the FRS. Our study further validated the FRS as a predictor of CVD risk in these patients. |
| format | Article |
| id | doaj-art-d308babd68f449cebf6da32449eef978 |
| institution | Kabale University |
| issn | 1477-7827 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Reproductive Biology and Endocrinology |
| spelling | doaj-art-d308babd68f449cebf6da32449eef9782025-02-09T13:00:01ZengBMCReproductive Biology and Endocrinology1477-78272025-02-0123111110.1186/s12958-025-01346-7Cardiovascular disease risk prediction by Framingham risk score in women with polycystic ovary syndromeMina Amiri0Maryam Mousavi1Mahsa Noroozzadeh2Fereidoun Azizi3Fahimeh Ramezani Tehrani4Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical SciencesReproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical SciencesReproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical SciencesEndocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical SciencesReproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical SciencesAbstract Background Despite the documented increased cardiovascular disease (CVD) risk in women with polycystic ovary syndrome (PCOS), no specific risk prediction tools are recommended for these patients. We aimed to assess the validity of the Framingham Risk Score (FRS) as a predictor of CVD risk in PCOS patients. Methods In a community-based prospective study, 4,435 women from the Tehran Lipid and Glucose Study (TLGS) cohort were analyzed. Among them, 215 women aged 30 years or older were diagnosed with PCOS. A Cox proportional hazards model applied to assess the relationship between the FRS and CVD event. Model accuracy was evaluated using the C-statistic, while discrimination and calibration were assessed via the ROC curve, area under the ROC curve (AUC) statistics, and the Hosmer- Lemeshow test. Results The Cox proportional hazards (HRs) model revealed that the CVD risk increased by 38% for each one-unit increase in the FRS [HR: 1.38 (95% CI: 1.14, 1.66)] in PCOS patients. The FRS had a C-statistic of 0.765, which indicated a satisfactory fit for CVD prediction in this population. The AUC of the ROC curve was 0.82, which demonstrated a good discrimination of the FRS. The Hosmer-Lemeshow test showed that the predicted probabilities of CVD were consistent with the observed CVD rates (p = 0.217), indicating a good calibration. Conclusions This study revealed a significant increase in CVD risk among PCOS patients. The FRS effectively predicts a 38% increment in CVD risk for every one-unit increase in the FRS. Our study further validated the FRS as a predictor of CVD risk in these patients.https://doi.org/10.1186/s12958-025-01346-7Cardiovascular disease (CVD)Polycystic ovary syndrome (PCOS)Framingham risk score (FRS)PredictionTehran lipid and glucose study (TLGS) |
| spellingShingle | Mina Amiri Maryam Mousavi Mahsa Noroozzadeh Fereidoun Azizi Fahimeh Ramezani Tehrani Cardiovascular disease risk prediction by Framingham risk score in women with polycystic ovary syndrome Reproductive Biology and Endocrinology Cardiovascular disease (CVD) Polycystic ovary syndrome (PCOS) Framingham risk score (FRS) Prediction Tehran lipid and glucose study (TLGS) |
| title | Cardiovascular disease risk prediction by Framingham risk score in women with polycystic ovary syndrome |
| title_full | Cardiovascular disease risk prediction by Framingham risk score in women with polycystic ovary syndrome |
| title_fullStr | Cardiovascular disease risk prediction by Framingham risk score in women with polycystic ovary syndrome |
| title_full_unstemmed | Cardiovascular disease risk prediction by Framingham risk score in women with polycystic ovary syndrome |
| title_short | Cardiovascular disease risk prediction by Framingham risk score in women with polycystic ovary syndrome |
| title_sort | cardiovascular disease risk prediction by framingham risk score in women with polycystic ovary syndrome |
| topic | Cardiovascular disease (CVD) Polycystic ovary syndrome (PCOS) Framingham risk score (FRS) Prediction Tehran lipid and glucose study (TLGS) |
| url | https://doi.org/10.1186/s12958-025-01346-7 |
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