Clinical presentation and treatment of thrombotic thrombocytopenic purpura - analysis of recent diagnostic and therapeutic methods
Introduction Thrombotic thrombocytopenic purpura (TTP) is a rare hematologic disease caused by reduced ADAMTS13 (A disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13) activity. This disease can lead to a variety of symptoms and be difficult to diagnose. Correct diagnosis...
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Kazimierz Wielki University
2025-03-01
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| Series: | Journal of Education, Health and Sport |
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| Online Access: | https://apcz.umk.pl/JEHS/article/view/57872 |
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| author | Jan Szwech Mateusz Matczak Karol Jasiński Aleksandra Broda Kacper Hoksa Krzysztof Jodłowski Ewa Dubniewicz Paula Majewska Alicja Staszek Wiktoria Łoskot |
| author_facet | Jan Szwech Mateusz Matczak Karol Jasiński Aleksandra Broda Kacper Hoksa Krzysztof Jodłowski Ewa Dubniewicz Paula Majewska Alicja Staszek Wiktoria Łoskot |
| author_sort | Jan Szwech |
| collection | DOAJ |
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Introduction
Thrombotic thrombocytopenic purpura (TTP) is a rare hematologic disease caused by reduced ADAMTS13 (A disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13) activity. This disease can lead to a variety of symptoms and be difficult to diagnose. Correct diagnosis is very important to reduce mortality and initiate appropriate treatment. New treatment methods may offer better chances of survival from this potentially fatal disease.
Aim of the study
The aim of the article was to evaluation of different diagnostic pathways and the effectiveness of treatment of thrombotic thrombocytopenic purpura. Drawing the attention of the medical community to the discussed issue. Highlighting the importance of the issue due to the high mortality rate in the absence of treatment.
Materials and methods
The article was prepared by analyzing multiple databases, including PubMed, Google Scholar, and Elsevier covering the period from 2018 to 2024.
Conclusion
Thrombotic thrombocytopenic purpura (TTP) is a rare but serious disease, especially if appropriate treatment is not initiated. There is need a special attention to TTP, as treatment needs to begin even before a definitive diagnosis is established, due to the lengthy wait for laboratory results. Although modern biological drugs are available, further research is needed to streamline treatment methods and provide new therapeutic opportunities.
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| format | Article |
| id | doaj-art-d302f7e593524e60849531caa7ab7158 |
| institution | DOAJ |
| issn | 2391-8306 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj-art-d302f7e593524e60849531caa7ab71582025-08-20T03:16:26ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062025-03-017910.12775/JEHS.2025.79.57872Clinical presentation and treatment of thrombotic thrombocytopenic purpura - analysis of recent diagnostic and therapeutic methodsJan Szwech0https://orcid.org/0009-0002-9312-8152Mateusz Matczak1https://orcid.org/0009-0000-9701-406XKarol Jasiński2https://orcid.org/0009-0004-6845-5199Aleksandra Broda3https://orcid.org/0009-0004-5179-9411Kacper Hoksa4https://orcid.org/0009-0007-9832-7093Krzysztof Jodłowski5https://orcid.org/0009-0003-9041-2091Ewa Dubniewicz6https://orcid.org/0009-0007-4191-6794Paula Majewska7https://orcid.org/0009-0003-7934-397XAlicja Staszek8https://orcid.org/0009-0007-0323-8697Wiktoria Łoskot9https://orcid.org/0009-0001-5392-4835Masovian Specialist Hospital, ul. Jana Aleksandrowicza 5, 26-617 RadomHospital of the Ministry of Interior and Administration in Lodz, ul. Północna 42, 91–425 LodzProvincial Hospital of St. Luke in Tarnow, 33-100 Tarnów, ul. Lwowska 178aHospital of the Ministry of Interior and Administration in Lodz, ul. Północna 42, 91–425 LodzHospital of the Ministry of Interior and Administration in Lodz, ul. Północna 42, 91–425 LodzHospital of the Ministry of Interior and Administration in Lodz, ul. Północna 42, 91–425 LodzCentral Clinical Hospital of Medical University of Lodz, ul. Pomorska 251, 92-213 LodzCentral Clinical Hospital of Medical University of Lodz, ul. Pomorska 251, 92-213 LodzCentral Clinical Hospital of Medical University of Lodz, ul. Pomorska 251, 92-213 LodzUniversity Clinical Hospital No. 2 of the Medical University of Lodz: Łódź, ul. Stefana Żeromskiego 113, 90-549 Łódź, PL Introduction Thrombotic thrombocytopenic purpura (TTP) is a rare hematologic disease caused by reduced ADAMTS13 (A disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13) activity. This disease can lead to a variety of symptoms and be difficult to diagnose. Correct diagnosis is very important to reduce mortality and initiate appropriate treatment. New treatment methods may offer better chances of survival from this potentially fatal disease. Aim of the study The aim of the article was to evaluation of different diagnostic pathways and the effectiveness of treatment of thrombotic thrombocytopenic purpura. Drawing the attention of the medical community to the discussed issue. Highlighting the importance of the issue due to the high mortality rate in the absence of treatment. Materials and methods The article was prepared by analyzing multiple databases, including PubMed, Google Scholar, and Elsevier covering the period from 2018 to 2024. Conclusion Thrombotic thrombocytopenic purpura (TTP) is a rare but serious disease, especially if appropriate treatment is not initiated. There is need a special attention to TTP, as treatment needs to begin even before a definitive diagnosis is established, due to the lengthy wait for laboratory results. Although modern biological drugs are available, further research is needed to streamline treatment methods and provide new therapeutic opportunities. https://apcz.umk.pl/JEHS/article/view/57872thrombotic thrombocytopenic purpurathrombocytopeniaADAMTS13 |
| spellingShingle | Jan Szwech Mateusz Matczak Karol Jasiński Aleksandra Broda Kacper Hoksa Krzysztof Jodłowski Ewa Dubniewicz Paula Majewska Alicja Staszek Wiktoria Łoskot Clinical presentation and treatment of thrombotic thrombocytopenic purpura - analysis of recent diagnostic and therapeutic methods Journal of Education, Health and Sport thrombotic thrombocytopenic purpura thrombocytopenia ADAMTS13 |
| title | Clinical presentation and treatment of thrombotic thrombocytopenic purpura - analysis of recent diagnostic and therapeutic methods |
| title_full | Clinical presentation and treatment of thrombotic thrombocytopenic purpura - analysis of recent diagnostic and therapeutic methods |
| title_fullStr | Clinical presentation and treatment of thrombotic thrombocytopenic purpura - analysis of recent diagnostic and therapeutic methods |
| title_full_unstemmed | Clinical presentation and treatment of thrombotic thrombocytopenic purpura - analysis of recent diagnostic and therapeutic methods |
| title_short | Clinical presentation and treatment of thrombotic thrombocytopenic purpura - analysis of recent diagnostic and therapeutic methods |
| title_sort | clinical presentation and treatment of thrombotic thrombocytopenic purpura analysis of recent diagnostic and therapeutic methods |
| topic | thrombotic thrombocytopenic purpura thrombocytopenia ADAMTS13 |
| url | https://apcz.umk.pl/JEHS/article/view/57872 |
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