Comparative Analysis of the Transcriptome of Latent Autoimmune Diabetes in Adult (LADA) Patients from Eastern China
Latent autoimmune diabetes in adults (LADA) is characterized as a slow-progressing form of autoimmune diabetes. LADA resembles some phenotypes of type 1 diabetes (T1D) and type 2 diabetes (T2D), frequently leading to misdiagnosis and inappropriate therapeutic strategies. Understanding its transcript...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
|
| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2019/8616373 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849473486510096384 |
|---|---|
| author | Yuqiao Ji Dongmei Jiang Jian Liu Xiaolong Chen Tian Xia Zhujun Yin Lei Li Hao Jin Hongmei Chen Mingzhong Sun |
| author_facet | Yuqiao Ji Dongmei Jiang Jian Liu Xiaolong Chen Tian Xia Zhujun Yin Lei Li Hao Jin Hongmei Chen Mingzhong Sun |
| author_sort | Yuqiao Ji |
| collection | DOAJ |
| description | Latent autoimmune diabetes in adults (LADA) is characterized as a slow-progressing form of autoimmune diabetes. LADA resembles some phenotypes of type 1 diabetes (T1D) and type 2 diabetes (T2D), frequently leading to misdiagnosis and inappropriate therapeutic strategies. Understanding its transcriptome profiles aids in revealing the detailed molecular mechanisms of LADA and its therapy. In the present study, we performed RNA-seq analysis of LADA patients from Eastern China and showed that LADA exhibited 277 differentially expressed genes (DEGs) with 199 upregulated and 78 downregulated. Gene ontology and KEGG pathway enrichment analysis revealed that these DEGs were mainly related to immune function and cell death and growth. Furthermore, a comparison of DEGs in LADA with those in T1D and T2D identified from the online databases showed that there are very few overlapped genes between LADA and T1D or T2D, confirming LADA to be a distinct type of diabetes from T1D or T2D. In summary, our comprehensive analysis may aid in the understanding and treatment of LADA patients in Eastern China. |
| format | Article |
| id | doaj-art-d2ff9c6cc3c6476fbe1e7142a3603263 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-d2ff9c6cc3c6476fbe1e7142a36032632025-08-20T03:24:07ZengWileyJournal of Diabetes Research2314-67452314-67532019-01-01201910.1155/2019/86163738616373Comparative Analysis of the Transcriptome of Latent Autoimmune Diabetes in Adult (LADA) Patients from Eastern ChinaYuqiao Ji0Dongmei Jiang1Jian Liu2Xiaolong Chen3Tian Xia4Zhujun Yin5Lei Li6Hao Jin7Hongmei Chen8Mingzhong Sun9Department of Clinical Laboratory, Affiliated Yancheng Hospital, School of Medicine, Southeast University, Yancheng, Jiangsu 224001, ChinaDepartment of Clinical Laboratory, Affiliated Yancheng Hospital, School of Medicine, Southeast University, Yancheng, Jiangsu 224001, ChinaReproductive & Developmental Biology Laboratory, National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC 27709, USADepartment of Clinical Laboratory, Affiliated Yancheng Hospital, School of Medicine, Southeast University, Yancheng, Jiangsu 224001, ChinaDepartment of Clinical Laboratory, Affiliated Yancheng Hospital, School of Medicine, Southeast University, Yancheng, Jiangsu 224001, ChinaDepartment of Clinical Laboratory, Affiliated Yancheng Hospital, School of Medicine, Southeast University, Yancheng, Jiangsu 224001, ChinaEast China Normal University, 500 Dongchuan Road, Shanghai 200241, ChinaDepartment of Clinical Laboratory, Affiliated Yancheng Hospital, School of Medicine, Southeast University, Yancheng, Jiangsu 224001, ChinaDepartment of Clinical Laboratory, Affiliated Yancheng Hospital, School of Medicine, Southeast University, Yancheng, Jiangsu 224001, ChinaDepartment of Clinical Laboratory, Affiliated Yancheng Hospital, School of Medicine, Southeast University, Yancheng, Jiangsu 224001, ChinaLatent autoimmune diabetes in adults (LADA) is characterized as a slow-progressing form of autoimmune diabetes. LADA resembles some phenotypes of type 1 diabetes (T1D) and type 2 diabetes (T2D), frequently leading to misdiagnosis and inappropriate therapeutic strategies. Understanding its transcriptome profiles aids in revealing the detailed molecular mechanisms of LADA and its therapy. In the present study, we performed RNA-seq analysis of LADA patients from Eastern China and showed that LADA exhibited 277 differentially expressed genes (DEGs) with 199 upregulated and 78 downregulated. Gene ontology and KEGG pathway enrichment analysis revealed that these DEGs were mainly related to immune function and cell death and growth. Furthermore, a comparison of DEGs in LADA with those in T1D and T2D identified from the online databases showed that there are very few overlapped genes between LADA and T1D or T2D, confirming LADA to be a distinct type of diabetes from T1D or T2D. In summary, our comprehensive analysis may aid in the understanding and treatment of LADA patients in Eastern China.http://dx.doi.org/10.1155/2019/8616373 |
| spellingShingle | Yuqiao Ji Dongmei Jiang Jian Liu Xiaolong Chen Tian Xia Zhujun Yin Lei Li Hao Jin Hongmei Chen Mingzhong Sun Comparative Analysis of the Transcriptome of Latent Autoimmune Diabetes in Adult (LADA) Patients from Eastern China Journal of Diabetes Research |
| title | Comparative Analysis of the Transcriptome of Latent Autoimmune Diabetes in Adult (LADA) Patients from Eastern China |
| title_full | Comparative Analysis of the Transcriptome of Latent Autoimmune Diabetes in Adult (LADA) Patients from Eastern China |
| title_fullStr | Comparative Analysis of the Transcriptome of Latent Autoimmune Diabetes in Adult (LADA) Patients from Eastern China |
| title_full_unstemmed | Comparative Analysis of the Transcriptome of Latent Autoimmune Diabetes in Adult (LADA) Patients from Eastern China |
| title_short | Comparative Analysis of the Transcriptome of Latent Autoimmune Diabetes in Adult (LADA) Patients from Eastern China |
| title_sort | comparative analysis of the transcriptome of latent autoimmune diabetes in adult lada patients from eastern china |
| url | http://dx.doi.org/10.1155/2019/8616373 |
| work_keys_str_mv | AT yuqiaoji comparativeanalysisofthetranscriptomeoflatentautoimmunediabetesinadultladapatientsfromeasternchina AT dongmeijiang comparativeanalysisofthetranscriptomeoflatentautoimmunediabetesinadultladapatientsfromeasternchina AT jianliu comparativeanalysisofthetranscriptomeoflatentautoimmunediabetesinadultladapatientsfromeasternchina AT xiaolongchen comparativeanalysisofthetranscriptomeoflatentautoimmunediabetesinadultladapatientsfromeasternchina AT tianxia comparativeanalysisofthetranscriptomeoflatentautoimmunediabetesinadultladapatientsfromeasternchina AT zhujunyin comparativeanalysisofthetranscriptomeoflatentautoimmunediabetesinadultladapatientsfromeasternchina AT leili comparativeanalysisofthetranscriptomeoflatentautoimmunediabetesinadultladapatientsfromeasternchina AT haojin comparativeanalysisofthetranscriptomeoflatentautoimmunediabetesinadultladapatientsfromeasternchina AT hongmeichen comparativeanalysisofthetranscriptomeoflatentautoimmunediabetesinadultladapatientsfromeasternchina AT mingzhongsun comparativeanalysisofthetranscriptomeoflatentautoimmunediabetesinadultladapatientsfromeasternchina |