GENETIC RISK FACTORS OF TROMBOPHILIA IN WOMEN OF REPRODUCTIVE AGE RESIDING IN KRASNODAR REGION
Оur paper presents the study of incidence rate of genetic polymorphism of hemostasis genes and folate cycle in patients with habitual miscarriage, residing in Krasnodar region. The property of reproduction age women with habitual miscarriage in juvenile age (75 patients) was the multigene nature of...
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| Format: | Article |
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IRBIS LLC
2016-06-01
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| Series: | Акушерство, гинекология и репродукция |
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| Online Access: | https://www.gynecology.su/jour/article/view/147 |
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| author | A. S. Adamchik D. I. Panchenko |
| author_facet | A. S. Adamchik D. I. Panchenko |
| author_sort | A. S. Adamchik |
| collection | DOAJ |
| description | Оur paper presents the study of incidence rate of genetic polymorphism of hemostasis genes and folate cycle in patients with habitual miscarriage, residing in Krasnodar region. The property of reproduction age women with habitual miscarriage in juvenile age (75 patients) was the multigene nature of trombophilia in 76.81% of cases (53 patients) from 69 patients with mutations (92% of total number of studied patients) at low percent of incidence of factor V (Leiden) and factor II (prothrombin) gene mutation. It shows that the management of pregnant women, decision on COCs and HRT administration can’t be made with testing of a limited number of the most thoroughly studied genes, considered as unconditional and strict markers of inherited thrombophilia (FV, F II, MTHFR С677Т). |
| format | Article |
| id | doaj-art-d2ff7a46470b47e8946388151d3aa461 |
| institution | Kabale University |
| issn | 2313-7347 2500-3194 |
| language | Russian |
| publishDate | 2016-06-01 |
| publisher | IRBIS LLC |
| record_format | Article |
| series | Акушерство, гинекология и репродукция |
| spelling | doaj-art-d2ff7a46470b47e8946388151d3aa4612025-08-20T03:57:36ZrusIRBIS LLCАкушерство, гинекология и репродукция2313-73472500-31942016-06-0191596210.17749/2313-7347.2015.9.1.059-062145GENETIC RISK FACTORS OF TROMBOPHILIA IN WOMEN OF REPRODUCTIVE AGE RESIDING IN KRASNODAR REGIONA. S. Adamchik0D. I. Panchenko1Kuban State Medical University of the Ministry of Health of Russia, MoscowKuban State Medical University of the Ministry of Health of Russia, MoscowОur paper presents the study of incidence rate of genetic polymorphism of hemostasis genes and folate cycle in patients with habitual miscarriage, residing in Krasnodar region. The property of reproduction age women with habitual miscarriage in juvenile age (75 patients) was the multigene nature of trombophilia in 76.81% of cases (53 patients) from 69 patients with mutations (92% of total number of studied patients) at low percent of incidence of factor V (Leiden) and factor II (prothrombin) gene mutation. It shows that the management of pregnant women, decision on COCs and HRT administration can’t be made with testing of a limited number of the most thoroughly studied genes, considered as unconditional and strict markers of inherited thrombophilia (FV, F II, MTHFR С677Т).https://www.gynecology.su/jour/article/view/147underlying risk for thrombosiswomen of reproductive agepolymorphic genetic markers |
| spellingShingle | A. S. Adamchik D. I. Panchenko GENETIC RISK FACTORS OF TROMBOPHILIA IN WOMEN OF REPRODUCTIVE AGE RESIDING IN KRASNODAR REGION Акушерство, гинекология и репродукция underlying risk for thrombosis women of reproductive age polymorphic genetic markers |
| title | GENETIC RISK FACTORS OF TROMBOPHILIA IN WOMEN OF REPRODUCTIVE AGE RESIDING IN KRASNODAR REGION |
| title_full | GENETIC RISK FACTORS OF TROMBOPHILIA IN WOMEN OF REPRODUCTIVE AGE RESIDING IN KRASNODAR REGION |
| title_fullStr | GENETIC RISK FACTORS OF TROMBOPHILIA IN WOMEN OF REPRODUCTIVE AGE RESIDING IN KRASNODAR REGION |
| title_full_unstemmed | GENETIC RISK FACTORS OF TROMBOPHILIA IN WOMEN OF REPRODUCTIVE AGE RESIDING IN KRASNODAR REGION |
| title_short | GENETIC RISK FACTORS OF TROMBOPHILIA IN WOMEN OF REPRODUCTIVE AGE RESIDING IN KRASNODAR REGION |
| title_sort | genetic risk factors of trombophilia in women of reproductive age residing in krasnodar region |
| topic | underlying risk for thrombosis women of reproductive age polymorphic genetic markers |
| url | https://www.gynecology.su/jour/article/view/147 |
| work_keys_str_mv | AT asadamchik geneticriskfactorsoftrombophiliainwomenofreproductiveageresidinginkrasnodarregion AT dipanchenko geneticriskfactorsoftrombophiliainwomenofreproductiveageresidinginkrasnodarregion |