Evaluating neurofilament light chain serum levels as a diagnostic marker for Lyme neuroborreliosis
Background: Serum neurofilament light chain (sNfL) is a biomarker for neuro-axonal injury. Objectives: To assess sNfL’s utility as a diagnostic marker for Lyme neuroborreliosis (LNB). Methods: We compared serum and CSF NfL levels in LNB patients and age-matched controls. Age-adjusted NfL values were...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-01-01
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| Series: | Therapeutic Advances in Neurological Disorders |
| Online Access: | https://doi.org/10.1177/17562864251314011 |
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| author | Cédric Hirzel Annina Grütter Denis Grandgirard Robert Hoepner Franziska Suter-Riniker Stephen L. Leib |
| author_facet | Cédric Hirzel Annina Grütter Denis Grandgirard Robert Hoepner Franziska Suter-Riniker Stephen L. Leib |
| author_sort | Cédric Hirzel |
| collection | DOAJ |
| description | Background: Serum neurofilament light chain (sNfL) is a biomarker for neuro-axonal injury. Objectives: To assess sNfL’s utility as a diagnostic marker for Lyme neuroborreliosis (LNB). Methods: We compared serum and CSF NfL levels in LNB patients and age-matched controls. Age-adjusted NfL values were used in receiver operating characteristic (ROC) analysis. Design: Retrospective cohort study. Results: Eighty-six patients (30 LNB, 29 with-, and 27 without neurological disorders) were included. Compared to individuals without neurological disease, LNB patients showed increased serum (median (interquartile range, IQR): 36.3 pg/ml (19.3–112.0) vs 20 pg/ml (12.9–37.3), p < 0.001) and CSF NfL levels (median (IQR): 1000.0 pg/ml (286.0–6471.0) vs 182 pg/ml (99.3–474.0), p < 0.001). NfL concentrations were similar in LNB and other neurological disorders. ROC analysis of age-adjusted sNfL and CSF NfL levels showed areas under the curve of 0.78 (95% confidence interval (CI): 0.66–0.89) and 0.83 (95% CI: 0.71–0.94), respectively. Conclusion: sNfL concentrations lack sufficient diagnostic capability for LNB diagnosis. |
| format | Article |
| id | doaj-art-d2fc3fcf38bd41b8b0d241da9624dbbf |
| institution | DOAJ |
| issn | 1756-2864 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SAGE Publishing |
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| series | Therapeutic Advances in Neurological Disorders |
| spelling | doaj-art-d2fc3fcf38bd41b8b0d241da9624dbbf2025-08-20T02:41:39ZengSAGE PublishingTherapeutic Advances in Neurological Disorders1756-28642025-01-011810.1177/17562864251314011Evaluating neurofilament light chain serum levels as a diagnostic marker for Lyme neuroborreliosisCédric HirzelAnnina GrütterDenis GrandgirardRobert HoepnerFranziska Suter-RinikerStephen L. LeibBackground: Serum neurofilament light chain (sNfL) is a biomarker for neuro-axonal injury. Objectives: To assess sNfL’s utility as a diagnostic marker for Lyme neuroborreliosis (LNB). Methods: We compared serum and CSF NfL levels in LNB patients and age-matched controls. Age-adjusted NfL values were used in receiver operating characteristic (ROC) analysis. Design: Retrospective cohort study. Results: Eighty-six patients (30 LNB, 29 with-, and 27 without neurological disorders) were included. Compared to individuals without neurological disease, LNB patients showed increased serum (median (interquartile range, IQR): 36.3 pg/ml (19.3–112.0) vs 20 pg/ml (12.9–37.3), p < 0.001) and CSF NfL levels (median (IQR): 1000.0 pg/ml (286.0–6471.0) vs 182 pg/ml (99.3–474.0), p < 0.001). NfL concentrations were similar in LNB and other neurological disorders. ROC analysis of age-adjusted sNfL and CSF NfL levels showed areas under the curve of 0.78 (95% confidence interval (CI): 0.66–0.89) and 0.83 (95% CI: 0.71–0.94), respectively. Conclusion: sNfL concentrations lack sufficient diagnostic capability for LNB diagnosis.https://doi.org/10.1177/17562864251314011 |
| spellingShingle | Cédric Hirzel Annina Grütter Denis Grandgirard Robert Hoepner Franziska Suter-Riniker Stephen L. Leib Evaluating neurofilament light chain serum levels as a diagnostic marker for Lyme neuroborreliosis Therapeutic Advances in Neurological Disorders |
| title | Evaluating neurofilament light chain serum levels as a diagnostic marker for Lyme neuroborreliosis |
| title_full | Evaluating neurofilament light chain serum levels as a diagnostic marker for Lyme neuroborreliosis |
| title_fullStr | Evaluating neurofilament light chain serum levels as a diagnostic marker for Lyme neuroborreliosis |
| title_full_unstemmed | Evaluating neurofilament light chain serum levels as a diagnostic marker for Lyme neuroborreliosis |
| title_short | Evaluating neurofilament light chain serum levels as a diagnostic marker for Lyme neuroborreliosis |
| title_sort | evaluating neurofilament light chain serum levels as a diagnostic marker for lyme neuroborreliosis |
| url | https://doi.org/10.1177/17562864251314011 |
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