Uptake, safety and effectiveness of inactivated influenza vaccine in inflammatory bowel disease: a UK-wide study
Objective To investigate (1) the UK-wide inactivated influenza vaccine (IIV) uptake in adults with inflammatory bowel disease (IBD), (2) the association between vaccination against influenza and IBD flare and (3) the effectiveness of IIV in preventing morbidity and mortality.Design Data for adults w...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2024-05-01
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| Series: | BMJ Open Gastroenterology |
| Online Access: | https://bmjopengastro.bmj.com/content/11/1/e001370.full |
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| author | Abhishek Abhishek Christian D Mallen Georgina Nakafero Matthew J Grainge Tim Card Jonathan S Nguyen Van-Tam |
| author_facet | Abhishek Abhishek Christian D Mallen Georgina Nakafero Matthew J Grainge Tim Card Jonathan S Nguyen Van-Tam |
| author_sort | Abhishek Abhishek |
| collection | DOAJ |
| description | Objective To investigate (1) the UK-wide inactivated influenza vaccine (IIV) uptake in adults with inflammatory bowel disease (IBD), (2) the association between vaccination against influenza and IBD flare and (3) the effectiveness of IIV in preventing morbidity and mortality.Design Data for adults with IBD diagnosed before the 1 September 2018 were extracted from the Clinical Practice Research Datalink Gold. We calculated the proportion of people vaccinated against seasonal influenza in the 2018–2019 influenza cycle. To investigate vaccine effectiveness, we calculated the propensity score (PS) for vaccination and conducted Cox proportional hazard regression with inverse-probability treatment weighting on PS. We employed self-controlled case series analysis to investigate the association between vaccination and IBD flare.Results Data for 13 631 people with IBD (50.4% male, mean age 52.9 years) were included. Fifty percent were vaccinated during the influenza cycle, while 32.1% were vaccinated on time, that is, before the seasonal influenza virus circulated in the community. IIV was associated with reduced all-cause mortality (aHR (95% CI): 0.73 (0.55,0.97) but not hospitalisation for pneumonia (aHR (95% CI) 0.52 (0.20–1.37), including in the influenza active period (aHR (95% CI) 0.48 (0.18–1.27)). Administration of the IIV was not associated with IBD flare.Conclusion The uptake of influenza vaccine was low in people with IBD, and the majority were not vaccinated before influenza virus circulated in the community. Vaccination with the IIV was not associated with IBD flare. These findings add to the evidence to promote vaccination against influenza in people with IBD. |
| format | Article |
| id | doaj-art-d2fb65834275484f82fb5885b4ba02b6 |
| institution | Kabale University |
| issn | 2054-4774 |
| language | English |
| publishDate | 2024-05-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open Gastroenterology |
| spelling | doaj-art-d2fb65834275484f82fb5885b4ba02b62025-02-12T07:35:12ZengBMJ Publishing GroupBMJ Open Gastroenterology2054-47742024-05-0111110.1136/bmjgast-2024-001370Uptake, safety and effectiveness of inactivated influenza vaccine in inflammatory bowel disease: a UK-wide studyAbhishek Abhishek0Christian D Mallen1Georgina Nakafero2Matthew J Grainge3Tim Card4Jonathan S Nguyen Van-Tam5Academic Rheumatology, University of Nottingham, Nottingham, UKKeele University School of Medicine, Keele, UKAcademic Rheumatology, University of Nottingham, Nottingham, UKLifespan and Population Health, University of Nottingham, Nottingham, UKLifespan and Population Health, University of Nottingham, Nottingham, UKLifespan and Population Health, University of Nottingham, Nottingham, UKObjective To investigate (1) the UK-wide inactivated influenza vaccine (IIV) uptake in adults with inflammatory bowel disease (IBD), (2) the association between vaccination against influenza and IBD flare and (3) the effectiveness of IIV in preventing morbidity and mortality.Design Data for adults with IBD diagnosed before the 1 September 2018 were extracted from the Clinical Practice Research Datalink Gold. We calculated the proportion of people vaccinated against seasonal influenza in the 2018–2019 influenza cycle. To investigate vaccine effectiveness, we calculated the propensity score (PS) for vaccination and conducted Cox proportional hazard regression with inverse-probability treatment weighting on PS. We employed self-controlled case series analysis to investigate the association between vaccination and IBD flare.Results Data for 13 631 people with IBD (50.4% male, mean age 52.9 years) were included. Fifty percent were vaccinated during the influenza cycle, while 32.1% were vaccinated on time, that is, before the seasonal influenza virus circulated in the community. IIV was associated with reduced all-cause mortality (aHR (95% CI): 0.73 (0.55,0.97) but not hospitalisation for pneumonia (aHR (95% CI) 0.52 (0.20–1.37), including in the influenza active period (aHR (95% CI) 0.48 (0.18–1.27)). Administration of the IIV was not associated with IBD flare.Conclusion The uptake of influenza vaccine was low in people with IBD, and the majority were not vaccinated before influenza virus circulated in the community. Vaccination with the IIV was not associated with IBD flare. These findings add to the evidence to promote vaccination against influenza in people with IBD.https://bmjopengastro.bmj.com/content/11/1/e001370.full |
| spellingShingle | Abhishek Abhishek Christian D Mallen Georgina Nakafero Matthew J Grainge Tim Card Jonathan S Nguyen Van-Tam Uptake, safety and effectiveness of inactivated influenza vaccine in inflammatory bowel disease: a UK-wide study BMJ Open Gastroenterology |
| title | Uptake, safety and effectiveness of inactivated influenza vaccine in inflammatory bowel disease: a UK-wide study |
| title_full | Uptake, safety and effectiveness of inactivated influenza vaccine in inflammatory bowel disease: a UK-wide study |
| title_fullStr | Uptake, safety and effectiveness of inactivated influenza vaccine in inflammatory bowel disease: a UK-wide study |
| title_full_unstemmed | Uptake, safety and effectiveness of inactivated influenza vaccine in inflammatory bowel disease: a UK-wide study |
| title_short | Uptake, safety and effectiveness of inactivated influenza vaccine in inflammatory bowel disease: a UK-wide study |
| title_sort | uptake safety and effectiveness of inactivated influenza vaccine in inflammatory bowel disease a uk wide study |
| url | https://bmjopengastro.bmj.com/content/11/1/e001370.full |
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