An Update on Clinical and Pathogenic Spectra of Leishmaniasis
Leishmaniasis, classified as a neglected tropical disease, exerts its impact on millions globally. Its clinical spectrum encompasses diverse forms, from benign self-resolving skin lesions (cutaneous leishmaniasis) to life-threatening visceral infections (visceral leishmaniasis or kala-azar). This re...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Cambridge University Press
2025-01-01
|
| Series: | Expert Reviews in Molecular Medicine |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S1462399425000043/type/journal_article |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849233074537103360 |
|---|---|
| author | Angamuthu Selvapandiyan Shital Shital Diya A’gitok Sangma Manju Jain Nadira Karunaweera Nirmal K. Ganguly |
| author_facet | Angamuthu Selvapandiyan Shital Shital Diya A’gitok Sangma Manju Jain Nadira Karunaweera Nirmal K. Ganguly |
| author_sort | Angamuthu Selvapandiyan |
| collection | DOAJ |
| description | Leishmaniasis, classified as a neglected tropical disease, exerts its impact on millions globally. Its clinical spectrum encompasses diverse forms, from benign self-resolving skin lesions (cutaneous leishmaniasis) to life-threatening visceral infections (visceral leishmaniasis or kala-azar). This review aims to comprehensively explore the spectrum of the disease as an outcome of often-overlooked parasite variants. Additionally, it addresses the emerging challenges faced in the pursuit towards disease elimination. The evolving landscape of leishmaniasis demands the development of molecular surveillance tools to detect the heterogeneous parasite strains that contribute to the emergence of new endemic foci. Such surveillance poses formidable challenges to current elimination strategies. As the disease landscape continues to evolve, understanding the molecular intricacies of causative parasite strains becomes paramount. This knowledge not only aids the understanding of the basis of emerging/shifting endemic areas but also facilitates the search for and the design of targeted interventions. In this context, this review will navigate through the dynamic terrain of leishmaniasis, the various causative species of Leishmania parasites emphasising the urgency for the development of robust surveillance mechanisms and innovative approaches to confront the evolving challenges in our quest for global disease elimination. |
| format | Article |
| id | doaj-art-d2fb39287c9a4eeb84f7424488b0a934 |
| institution | Kabale University |
| issn | 1462-3994 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Expert Reviews in Molecular Medicine |
| spelling | doaj-art-d2fb39287c9a4eeb84f7424488b0a9342025-08-20T12:57:28ZengCambridge University PressExpert Reviews in Molecular Medicine1462-39942025-01-012710.1017/erm.2025.4An Update on Clinical and Pathogenic Spectra of LeishmaniasisAngamuthu Selvapandiyan0https://orcid.org/0000-0002-2194-1534Shital Shital1Diya A’gitok Sangma2Manju Jain3Nadira Karunaweera4Nirmal K. Ganguly5Department of Molecular Medicine, Jamia Hamdard University, New Delhi, IndiaDepartment of Molecular Medicine, Jamia Hamdard University, New Delhi, IndiaDepartment of Biochemistry, Central University of Punjab, Bathinda, IndiaDepartment of Biochemistry, Central University of Punjab, Bathinda, IndiaDepartment of Parasitology, Faculty of Medicine, University of Colombo, Colombo, Sri LankaDepartment of Research, Sir Gangaram Hospital, New Delhi, IndiaLeishmaniasis, classified as a neglected tropical disease, exerts its impact on millions globally. Its clinical spectrum encompasses diverse forms, from benign self-resolving skin lesions (cutaneous leishmaniasis) to life-threatening visceral infections (visceral leishmaniasis or kala-azar). This review aims to comprehensively explore the spectrum of the disease as an outcome of often-overlooked parasite variants. Additionally, it addresses the emerging challenges faced in the pursuit towards disease elimination. The evolving landscape of leishmaniasis demands the development of molecular surveillance tools to detect the heterogeneous parasite strains that contribute to the emergence of new endemic foci. Such surveillance poses formidable challenges to current elimination strategies. As the disease landscape continues to evolve, understanding the molecular intricacies of causative parasite strains becomes paramount. This knowledge not only aids the understanding of the basis of emerging/shifting endemic areas but also facilitates the search for and the design of targeted interventions. In this context, this review will navigate through the dynamic terrain of leishmaniasis, the various causative species of Leishmania parasites emphasising the urgency for the development of robust surveillance mechanisms and innovative approaches to confront the evolving challenges in our quest for global disease elimination.https://www.cambridge.org/core/product/identifier/S1462399425000043/type/journal_articleclinical challengescutaneous leishmaniasisco-infectionsmolecular toolsmucocutaneous leishmaniasisvisceral leishmaniasis |
| spellingShingle | Angamuthu Selvapandiyan Shital Shital Diya A’gitok Sangma Manju Jain Nadira Karunaweera Nirmal K. Ganguly An Update on Clinical and Pathogenic Spectra of Leishmaniasis Expert Reviews in Molecular Medicine clinical challenges cutaneous leishmaniasis co-infections molecular tools mucocutaneous leishmaniasis visceral leishmaniasis |
| title | An Update on Clinical and Pathogenic Spectra of Leishmaniasis |
| title_full | An Update on Clinical and Pathogenic Spectra of Leishmaniasis |
| title_fullStr | An Update on Clinical and Pathogenic Spectra of Leishmaniasis |
| title_full_unstemmed | An Update on Clinical and Pathogenic Spectra of Leishmaniasis |
| title_short | An Update on Clinical and Pathogenic Spectra of Leishmaniasis |
| title_sort | update on clinical and pathogenic spectra of leishmaniasis |
| topic | clinical challenges cutaneous leishmaniasis co-infections molecular tools mucocutaneous leishmaniasis visceral leishmaniasis |
| url | https://www.cambridge.org/core/product/identifier/S1462399425000043/type/journal_article |
| work_keys_str_mv | AT angamuthuselvapandiyan anupdateonclinicalandpathogenicspectraofleishmaniasis AT shitalshital anupdateonclinicalandpathogenicspectraofleishmaniasis AT diyaagitoksangma anupdateonclinicalandpathogenicspectraofleishmaniasis AT manjujain anupdateonclinicalandpathogenicspectraofleishmaniasis AT nadirakarunaweera anupdateonclinicalandpathogenicspectraofleishmaniasis AT nirmalkganguly anupdateonclinicalandpathogenicspectraofleishmaniasis AT angamuthuselvapandiyan updateonclinicalandpathogenicspectraofleishmaniasis AT shitalshital updateonclinicalandpathogenicspectraofleishmaniasis AT diyaagitoksangma updateonclinicalandpathogenicspectraofleishmaniasis AT manjujain updateonclinicalandpathogenicspectraofleishmaniasis AT nadirakarunaweera updateonclinicalandpathogenicspectraofleishmaniasis AT nirmalkganguly updateonclinicalandpathogenicspectraofleishmaniasis |