Cardiovascular Risk Profiles amongst Women in a Multiethnic Population in Inner City Britain: A Potential Impact of Anaemia
The risk of diabetes is markedly reduced in men with iron deficiency anaemia (IDA). The nature of this relationship in women is not clear, nor is there information about the influence of ethnicity, given the increased susceptibility of diabetes amongst South Asians and Afro-Caribbeans. We reviewed 3...
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| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2013/303859 |
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| author | Julia Chackathayil Jeetesh V. Patel Paramjit S. Gill Rahul Potluri Ammar Natalwala Hardeep Uppal Deepthi Lavu Reinhard Heun Elizabeth A. Hughes Gregory Y. H. Lip |
| author_facet | Julia Chackathayil Jeetesh V. Patel Paramjit S. Gill Rahul Potluri Ammar Natalwala Hardeep Uppal Deepthi Lavu Reinhard Heun Elizabeth A. Hughes Gregory Y. H. Lip |
| author_sort | Julia Chackathayil |
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| description | The risk of diabetes is markedly reduced in men with iron deficiency anaemia (IDA). The nature of this relationship in women is not clear, nor is there information about the influence of ethnicity, given the increased susceptibility of diabetes amongst South Asians and Afro-Caribbeans. We reviewed 3563 patients with a diagnosis of anaemia from 2000 to 2007. The age-adjusted prevalence of vitamin B12 deficiency and IDA was calculated, together with cardiovascular comorbidities amongst Caucasians, South Asians, and Afro-Caribbeans. The prevalence of vitamin B12 deficiency (women only) or IDA was markedly higher in South Asians compared to Caucasians and Afro-Caribbeans. Among women with IDA, diabetes was more prevalent among South Asians (45%, 95% CI 39.0–51.0) compared to Caucasians (3.0%, 2.1–4.0); P<0.001. Among South Asian women with vitamin B12 deficiency, the prevalence of diabetes was reduced 8.5% (5.2–12.0). South Asian women with vitamin B12 deficiency had a higher prevalence of myocardial infarction (MI) and ischemic heart disease (IHD), but this relationship was reversed in IDA. IDA is associated with a greater prevalence of diabetes in South Asian women, but it is not coordinated by a greater risk of macrovascular complications. Given the cardiovascular impact of diabetes in South Asians, this association merits further study in relation to its pathophysiological implication. |
| format | Article |
| id | doaj-art-d2eab921d07749c2bceb9f9fd060aa2a |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-d2eab921d07749c2bceb9f9fd060aa2a2025-08-20T03:24:07ZengWileyInternational Journal of Endocrinology1687-83371687-83452013-01-01201310.1155/2013/303859303859Cardiovascular Risk Profiles amongst Women in a Multiethnic Population in Inner City Britain: A Potential Impact of AnaemiaJulia Chackathayil0Jeetesh V. Patel1Paramjit S. Gill2Rahul Potluri3Ammar Natalwala4Hardeep Uppal5Deepthi Lavu6Reinhard Heun7Elizabeth A. Hughes8Gregory Y. H. Lip9University of Birmingham, Centre for Cardiovascular Sciences, City Hospital, Birmingham B18 7QH and Sandwell Medical Research Unit, Sandwell General Hospital, West Bromwich, West Midlands B71 4HJ, UKUniversity of Birmingham, Centre for Cardiovascular Sciences, City Hospital, Birmingham B18 7QH and Sandwell Medical Research Unit, Sandwell General Hospital, West Bromwich, West Midlands B71 4HJ, UKPrimary Care Clinical Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UKDepartment of Cardiovascular Medicine, University of Manchester, Manchester M13 9NT, UKDivision of Medical Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UKDivision of Medical Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UKDepartment of Obstetrics and Gynaecology, University Hospital of North Staffordshire, Stoke-on-Trent, UKDepartment of Psychiatry, Derby City General Hospital, Uttoxeter Road, Derby DE22 3NE, UKUniversity of Birmingham, Centre for Cardiovascular Sciences, City Hospital, Birmingham B18 7QH and Sandwell Medical Research Unit, Sandwell General Hospital, West Bromwich, West Midlands B71 4HJ, UKUniversity of Birmingham, Centre for Cardiovascular Sciences, City Hospital, Birmingham B18 7QH and Sandwell Medical Research Unit, Sandwell General Hospital, West Bromwich, West Midlands B71 4HJ, UKThe risk of diabetes is markedly reduced in men with iron deficiency anaemia (IDA). The nature of this relationship in women is not clear, nor is there information about the influence of ethnicity, given the increased susceptibility of diabetes amongst South Asians and Afro-Caribbeans. We reviewed 3563 patients with a diagnosis of anaemia from 2000 to 2007. The age-adjusted prevalence of vitamin B12 deficiency and IDA was calculated, together with cardiovascular comorbidities amongst Caucasians, South Asians, and Afro-Caribbeans. The prevalence of vitamin B12 deficiency (women only) or IDA was markedly higher in South Asians compared to Caucasians and Afro-Caribbeans. Among women with IDA, diabetes was more prevalent among South Asians (45%, 95% CI 39.0–51.0) compared to Caucasians (3.0%, 2.1–4.0); P<0.001. Among South Asian women with vitamin B12 deficiency, the prevalence of diabetes was reduced 8.5% (5.2–12.0). South Asian women with vitamin B12 deficiency had a higher prevalence of myocardial infarction (MI) and ischemic heart disease (IHD), but this relationship was reversed in IDA. IDA is associated with a greater prevalence of diabetes in South Asian women, but it is not coordinated by a greater risk of macrovascular complications. Given the cardiovascular impact of diabetes in South Asians, this association merits further study in relation to its pathophysiological implication.http://dx.doi.org/10.1155/2013/303859 |
| spellingShingle | Julia Chackathayil Jeetesh V. Patel Paramjit S. Gill Rahul Potluri Ammar Natalwala Hardeep Uppal Deepthi Lavu Reinhard Heun Elizabeth A. Hughes Gregory Y. H. Lip Cardiovascular Risk Profiles amongst Women in a Multiethnic Population in Inner City Britain: A Potential Impact of Anaemia International Journal of Endocrinology |
| title | Cardiovascular Risk Profiles amongst Women in a Multiethnic Population in Inner City Britain: A Potential Impact of Anaemia |
| title_full | Cardiovascular Risk Profiles amongst Women in a Multiethnic Population in Inner City Britain: A Potential Impact of Anaemia |
| title_fullStr | Cardiovascular Risk Profiles amongst Women in a Multiethnic Population in Inner City Britain: A Potential Impact of Anaemia |
| title_full_unstemmed | Cardiovascular Risk Profiles amongst Women in a Multiethnic Population in Inner City Britain: A Potential Impact of Anaemia |
| title_short | Cardiovascular Risk Profiles amongst Women in a Multiethnic Population in Inner City Britain: A Potential Impact of Anaemia |
| title_sort | cardiovascular risk profiles amongst women in a multiethnic population in inner city britain a potential impact of anaemia |
| url | http://dx.doi.org/10.1155/2013/303859 |
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