THE EFFECT OF GLUTATHIONE DEPLETOR AND INDUCERS IN THE BILIARY EXCRETION OF CADMIUM AND ZINC IN RATS.
The effect of hepatic glutathione (GSH) depletion and enzymes Induction on hepatic glutathione S-transferase (GST’s) activity, biliary excretion of GSH cadmium, zinc was studied in rats. The GSH depletor Methyl Iodide did not Influence hepatic GST activity but depending on the substrate used , Pheno...
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College of Veterinary Medicine, University of Basrah, Iraq
2009-12-01
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| Series: | Basrah Journal of Veterinary Research |
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| Online Access: | https://bjvr.uobasrah.edu.iq/article_56913_b11843dfa42e03faa45f8a53ed9df34e.pdf |
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| author | Abdel Khailq.A.A Hanaa.A.Abbas May.J.Abed |
| author_facet | Abdel Khailq.A.A Hanaa.A.Abbas May.J.Abed |
| author_sort | Abdel Khailq.A.A |
| collection | DOAJ |
| description | The effect of hepatic glutathione (GSH) depletion and enzymes Induction on hepatic glutathione S-transferase (GST’s) activity, biliary excretion of GSH cadmium, zinc was studied in rats.
The GSH depletor Methyl Iodide did not Influence hepatic GST activity but depending on the substrate used , Phenobarbital benzopyeren increased it by 50-60% , 20-30% respectively GSH depletor decreased (60%) , benzopyrene did not effect
Phenobarbital increase(90%) the transport of GSH into bile.The biliary excretion of cadmium and zinc was reduced by methyl iodide depletor (52-65%) and enhanced by Phenobarbital (99- 110)% . treatment with benzopyrene did not affect the excretion of zinc into bile ,but decreased that of cadmium, these result do not provide evidence for the role of hepatic GST but support the importance of biliary GSH excretion in the hepatobiliary transport of cadmium & zinc .
It is assumed that Phenobarbital enhance the biliary excretion of metals by increasing the transport of GSH as a chemical complexation (cadmium-glutathione, zinc-glutathion) while the benzopyrene was less effect . |
| format | Article |
| id | doaj-art-d2e8a992a0794f9789ffcd2c15796b0b |
| institution | OA Journals |
| issn | 1813-8497 2410-8456 |
| language | English |
| publishDate | 2009-12-01 |
| publisher | College of Veterinary Medicine, University of Basrah, Iraq |
| record_format | Article |
| series | Basrah Journal of Veterinary Research |
| spelling | doaj-art-d2e8a992a0794f9789ffcd2c15796b0b2025-08-20T02:31:27ZengCollege of Veterinary Medicine, University of Basrah, IraqBasrah Journal of Veterinary Research1813-84972410-84562009-12-018210410910.33762/bvetr.2009.5691356913THE EFFECT OF GLUTATHIONE DEPLETOR AND INDUCERS IN THE BILIARY EXCRETION OF CADMIUM AND ZINC IN RATS.Abdel Khailq.A.AHanaa.A.AbbasMay.J.AbedThe effect of hepatic glutathione (GSH) depletion and enzymes Induction on hepatic glutathione S-transferase (GST’s) activity, biliary excretion of GSH cadmium, zinc was studied in rats. The GSH depletor Methyl Iodide did not Influence hepatic GST activity but depending on the substrate used , Phenobarbital benzopyeren increased it by 50-60% , 20-30% respectively GSH depletor decreased (60%) , benzopyrene did not effect Phenobarbital increase(90%) the transport of GSH into bile.The biliary excretion of cadmium and zinc was reduced by methyl iodide depletor (52-65%) and enhanced by Phenobarbital (99- 110)% . treatment with benzopyrene did not affect the excretion of zinc into bile ,but decreased that of cadmium, these result do not provide evidence for the role of hepatic GST but support the importance of biliary GSH excretion in the hepatobiliary transport of cadmium & zinc . It is assumed that Phenobarbital enhance the biliary excretion of metals by increasing the transport of GSH as a chemical complexation (cadmium-glutathione, zinc-glutathion) while the benzopyrene was less effect .https://bjvr.uobasrah.edu.iq/article_56913_b11843dfa42e03faa45f8a53ed9df34e.pdfzinkgstphenobarbital |
| spellingShingle | Abdel Khailq.A.A Hanaa.A.Abbas May.J.Abed THE EFFECT OF GLUTATHIONE DEPLETOR AND INDUCERS IN THE BILIARY EXCRETION OF CADMIUM AND ZINC IN RATS. Basrah Journal of Veterinary Research zink gst phenobarbital |
| title | THE EFFECT OF GLUTATHIONE DEPLETOR AND INDUCERS IN THE BILIARY EXCRETION OF CADMIUM AND ZINC IN RATS. |
| title_full | THE EFFECT OF GLUTATHIONE DEPLETOR AND INDUCERS IN THE BILIARY EXCRETION OF CADMIUM AND ZINC IN RATS. |
| title_fullStr | THE EFFECT OF GLUTATHIONE DEPLETOR AND INDUCERS IN THE BILIARY EXCRETION OF CADMIUM AND ZINC IN RATS. |
| title_full_unstemmed | THE EFFECT OF GLUTATHIONE DEPLETOR AND INDUCERS IN THE BILIARY EXCRETION OF CADMIUM AND ZINC IN RATS. |
| title_short | THE EFFECT OF GLUTATHIONE DEPLETOR AND INDUCERS IN THE BILIARY EXCRETION OF CADMIUM AND ZINC IN RATS. |
| title_sort | effect of glutathione depletor and inducers in the biliary excretion of cadmium and zinc in rats |
| topic | zink gst phenobarbital |
| url | https://bjvr.uobasrah.edu.iq/article_56913_b11843dfa42e03faa45f8a53ed9df34e.pdf |
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