Bioprinting-By-Design of Hydrogel-Based Biomaterials for In Situ Skin Tissue Engineering
Burns are one of the most common trauma injuries worldwide and have detrimental effects on the entire body. However, the current standard of care is autologous split thickness skin grafts (STSGs), which induces additional injuries to the patient. Therefore, the development of alternative treatments...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-02-01
|
| Series: | Gels |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2310-2861/11/2/110 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850080150537895936 |
|---|---|
| author | Alisa Douglas Yufei Chen Margarita Elloso Adam Levschuk Marc G. Jeschke |
| author_facet | Alisa Douglas Yufei Chen Margarita Elloso Adam Levschuk Marc G. Jeschke |
| author_sort | Alisa Douglas |
| collection | DOAJ |
| description | Burns are one of the most common trauma injuries worldwide and have detrimental effects on the entire body. However, the current standard of care is autologous split thickness skin grafts (STSGs), which induces additional injuries to the patient. Therefore, the development of alternative treatments to replace traditional STSGs is critical, and bioprinting could be the future of burn care. Specifically, in situ bioprinting offers several advantages in clinical applications compared to conventional in vitro bioprinting, primarily due to its ability to deposit bioink directly onto the wound. This review provides an in-depth discussion of the aspects involved in in situ bioprinting for skin regeneration, including crosslinking mechanisms, properties of natural and synthetic hydrogel-based bioinks, various in situ bioprinting methods, and the clinical translation of in situ bioprinting. The current limitations of in situ bioprinting is the ideal combination of bioink and printing mechanism to allow multi-material dispensing or to produce well-orchestrated constructs in a timely manner in clinical settings. However, extensive ongoing research is focused on addressing these challenges, and they do not diminish the significant potential of in situ bioprinting for skin regeneration. |
| format | Article |
| id | doaj-art-d2e72e45d0034542972e3e78e1efae3e |
| institution | DOAJ |
| issn | 2310-2861 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj-art-d2e72e45d0034542972e3e78e1efae3e2025-08-20T02:45:00ZengMDPI AGGels2310-28612025-02-0111211010.3390/gels11020110Bioprinting-By-Design of Hydrogel-Based Biomaterials for In Situ Skin Tissue EngineeringAlisa Douglas0Yufei Chen1Margarita Elloso2Adam Levschuk3Marc G. Jeschke4Department of School of Biomedical Engineering, McMaster University, Hamilton, ON L8S 4L8, CanadaDavid Braley Research Institute, Hamilton, ON L8L 2X2, CanadaHamilton Health Sciences, Hamilton, ON L8L 0A4, CanadaSchulich School of Medicine and Dentistry, Western University, London, ON N6A 5C1, CanadaDepartment of School of Biomedical Engineering, McMaster University, Hamilton, ON L8S 4L8, CanadaBurns are one of the most common trauma injuries worldwide and have detrimental effects on the entire body. However, the current standard of care is autologous split thickness skin grafts (STSGs), which induces additional injuries to the patient. Therefore, the development of alternative treatments to replace traditional STSGs is critical, and bioprinting could be the future of burn care. Specifically, in situ bioprinting offers several advantages in clinical applications compared to conventional in vitro bioprinting, primarily due to its ability to deposit bioink directly onto the wound. This review provides an in-depth discussion of the aspects involved in in situ bioprinting for skin regeneration, including crosslinking mechanisms, properties of natural and synthetic hydrogel-based bioinks, various in situ bioprinting methods, and the clinical translation of in situ bioprinting. The current limitations of in situ bioprinting is the ideal combination of bioink and printing mechanism to allow multi-material dispensing or to produce well-orchestrated constructs in a timely manner in clinical settings. However, extensive ongoing research is focused on addressing these challenges, and they do not diminish the significant potential of in situ bioprinting for skin regeneration.https://www.mdpi.com/2310-2861/11/2/110hydrogelbioprintingin situburnsskin regenerationbioink |
| spellingShingle | Alisa Douglas Yufei Chen Margarita Elloso Adam Levschuk Marc G. Jeschke Bioprinting-By-Design of Hydrogel-Based Biomaterials for In Situ Skin Tissue Engineering Gels hydrogel bioprinting in situ burns skin regeneration bioink |
| title | Bioprinting-By-Design of Hydrogel-Based Biomaterials for In Situ Skin Tissue Engineering |
| title_full | Bioprinting-By-Design of Hydrogel-Based Biomaterials for In Situ Skin Tissue Engineering |
| title_fullStr | Bioprinting-By-Design of Hydrogel-Based Biomaterials for In Situ Skin Tissue Engineering |
| title_full_unstemmed | Bioprinting-By-Design of Hydrogel-Based Biomaterials for In Situ Skin Tissue Engineering |
| title_short | Bioprinting-By-Design of Hydrogel-Based Biomaterials for In Situ Skin Tissue Engineering |
| title_sort | bioprinting by design of hydrogel based biomaterials for in situ skin tissue engineering |
| topic | hydrogel bioprinting in situ burns skin regeneration bioink |
| url | https://www.mdpi.com/2310-2861/11/2/110 |
| work_keys_str_mv | AT alisadouglas bioprintingbydesignofhydrogelbasedbiomaterialsforinsituskintissueengineering AT yufeichen bioprintingbydesignofhydrogelbasedbiomaterialsforinsituskintissueengineering AT margaritaelloso bioprintingbydesignofhydrogelbasedbiomaterialsforinsituskintissueengineering AT adamlevschuk bioprintingbydesignofhydrogelbasedbiomaterialsforinsituskintissueengineering AT marcgjeschke bioprintingbydesignofhydrogelbasedbiomaterialsforinsituskintissueengineering |