Prognostic and clinicopathological significance of C-reactive protein–albumin–lymphocyte(CALLY) in patients with digestive system neoplasms: a systematic review and meta-analysis
Abstract Objective The prognostic significance of the C-reactive protein-albumin-lymphocyte (CALLY) index in digestive system neoplasms (DSNs) has been investigated in several studies, but inconsistencies remain between the results of different studies. Therefore, the aim of this study was to confir...
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BMC
2025-04-01
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| Series: | World Journal of Surgical Oncology |
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| Online Access: | https://doi.org/10.1186/s12957-025-03779-1 |
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| author | Dengzhuo Chen Yongli Ma Jinghui Li Liang Wen Linfeng Liu Jiarui Su Jiawei Wu Ping Wang Guosheng Zhang Chengzhi Huang Xueqing Yao |
| author_facet | Dengzhuo Chen Yongli Ma Jinghui Li Liang Wen Linfeng Liu Jiarui Su Jiawei Wu Ping Wang Guosheng Zhang Chengzhi Huang Xueqing Yao |
| author_sort | Dengzhuo Chen |
| collection | DOAJ |
| description | Abstract Objective The prognostic significance of the C-reactive protein-albumin-lymphocyte (CALLY) index in digestive system neoplasms (DSNs) has been investigated in several studies, but inconsistencies remain between the results of different studies. Therefore, the aim of this study was to confirm the prognostic significance of CALLY in patients with DSNs and its association with clinicopathological characteristics (CPCs). Methods The databases PubMed, Cochrane Library, Web of Science, Research Square and Embase were systematically searched for clinical trials with databases up to 1 November 2024. The value of CALLY in predicting overall survival (OS), disease-free survival (DFS) and recurrence-free survival (RFS) versus cancer-specific survival (CSS) in patients with DSNs was confirmed by calculating the combined hazard ratio (HR) and 95% CI. The combined OR and 95% CI were calculated to assess the association between CALLY and CPCs in patients with DSNs. Results A total of 18 studies with 7916 patients with DSNs were included in this study. Pooled analysis showed that lower CALLY was associated with poor OS, DFS, RFS and CSS were significantly associated. In addition, low CALLY index was associated with male gender, T3-T4, lymph node metastasis, lymph vessel invasion, complications, stage III-IV and surgical approach were significantly associated. However, there was no association between low CALLY index and histological type, adjuvant chemotherapy, and neoadjuvant chemotherapy. Conclusions In this meta-analysis, a low CALLY index was significantly associated with poor OS, DFS, RFS and CSS in patients with DSNs and with several CPCs in patients with DSNs. Systematic review registration PROSPERO CRD42024622973. |
| format | Article |
| id | doaj-art-d2e6cada45bd4fabacbf596fbc18b37e |
| institution | DOAJ |
| issn | 1477-7819 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
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| series | World Journal of Surgical Oncology |
| spelling | doaj-art-d2e6cada45bd4fabacbf596fbc18b37e2025-08-20T03:07:41ZengBMCWorld Journal of Surgical Oncology1477-78192025-04-0123111810.1186/s12957-025-03779-1Prognostic and clinicopathological significance of C-reactive protein–albumin–lymphocyte(CALLY) in patients with digestive system neoplasms: a systematic review and meta-analysisDengzhuo Chen0Yongli Ma1Jinghui Li2Liang Wen3Linfeng Liu4Jiarui Su5Jiawei Wu6Ping Wang7Guosheng Zhang8Chengzhi Huang9Xueqing Yao10Gannan Medical UniversityGanzhou Hospital of Guangdong Provincial People’s Hospital, Ganzhou Municipal HospitalGannan Medical UniversityGannan Medical UniversityGannan Medical UniversityDepartment of Gastrointestinal Surgery, Department of General Surgery, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical UniversityDepartment of Gastrointestinal Surgery, Department of General Surgery, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical UniversityDepartment of Gastrointestinal Surgery, Department of General Surgery, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical UniversityGanzhou Hospital of Guangdong Provincial People’s Hospital, Ganzhou Municipal HospitalDepartment of Gastrointestinal Surgery, Department of General Surgery, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical UniversityGannan Medical UniversityAbstract Objective The prognostic significance of the C-reactive protein-albumin-lymphocyte (CALLY) index in digestive system neoplasms (DSNs) has been investigated in several studies, but inconsistencies remain between the results of different studies. Therefore, the aim of this study was to confirm the prognostic significance of CALLY in patients with DSNs and its association with clinicopathological characteristics (CPCs). Methods The databases PubMed, Cochrane Library, Web of Science, Research Square and Embase were systematically searched for clinical trials with databases up to 1 November 2024. The value of CALLY in predicting overall survival (OS), disease-free survival (DFS) and recurrence-free survival (RFS) versus cancer-specific survival (CSS) in patients with DSNs was confirmed by calculating the combined hazard ratio (HR) and 95% CI. The combined OR and 95% CI were calculated to assess the association between CALLY and CPCs in patients with DSNs. Results A total of 18 studies with 7916 patients with DSNs were included in this study. Pooled analysis showed that lower CALLY was associated with poor OS, DFS, RFS and CSS were significantly associated. In addition, low CALLY index was associated with male gender, T3-T4, lymph node metastasis, lymph vessel invasion, complications, stage III-IV and surgical approach were significantly associated. However, there was no association between low CALLY index and histological type, adjuvant chemotherapy, and neoadjuvant chemotherapy. Conclusions In this meta-analysis, a low CALLY index was significantly associated with poor OS, DFS, RFS and CSS in patients with DSNs and with several CPCs in patients with DSNs. Systematic review registration PROSPERO CRD42024622973.https://doi.org/10.1186/s12957-025-03779-1C-reactive protein–albumin–lymphocyteDigestive system neoplasmsMeta-analysisPrognosis |
| spellingShingle | Dengzhuo Chen Yongli Ma Jinghui Li Liang Wen Linfeng Liu Jiarui Su Jiawei Wu Ping Wang Guosheng Zhang Chengzhi Huang Xueqing Yao Prognostic and clinicopathological significance of C-reactive protein–albumin–lymphocyte(CALLY) in patients with digestive system neoplasms: a systematic review and meta-analysis World Journal of Surgical Oncology C-reactive protein–albumin–lymphocyte Digestive system neoplasms Meta-analysis Prognosis |
| title | Prognostic and clinicopathological significance of C-reactive protein–albumin–lymphocyte(CALLY) in patients with digestive system neoplasms: a systematic review and meta-analysis |
| title_full | Prognostic and clinicopathological significance of C-reactive protein–albumin–lymphocyte(CALLY) in patients with digestive system neoplasms: a systematic review and meta-analysis |
| title_fullStr | Prognostic and clinicopathological significance of C-reactive protein–albumin–lymphocyte(CALLY) in patients with digestive system neoplasms: a systematic review and meta-analysis |
| title_full_unstemmed | Prognostic and clinicopathological significance of C-reactive protein–albumin–lymphocyte(CALLY) in patients with digestive system neoplasms: a systematic review and meta-analysis |
| title_short | Prognostic and clinicopathological significance of C-reactive protein–albumin–lymphocyte(CALLY) in patients with digestive system neoplasms: a systematic review and meta-analysis |
| title_sort | prognostic and clinicopathological significance of c reactive protein albumin lymphocyte cally in patients with digestive system neoplasms a systematic review and meta analysis |
| topic | C-reactive protein–albumin–lymphocyte Digestive system neoplasms Meta-analysis Prognosis |
| url | https://doi.org/10.1186/s12957-025-03779-1 |
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