Cohort profile: patient characteristics and quality-of-life measurements for newly-referred patients with atrial fibrillation—Keio interhospital Cardiovascular Studies-atrial fibrillation (KiCS-AF)
Purpose Besides the high rates of morbidity and mortality, atrial fibrillation (AF) is also associated with impairment of quality-of-life (QOL). However, reports covering non-selected AF population within Asian countries remain scarce. The objective of the Keio interhospital Cardiovascular Studies-a...
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BMJ Publishing Group
2019-12-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/9/12/e032746.full |
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| author | Iwao Nakamura Ikuko Ueda Keiichi Fukuda Shun Kohsaka John A Spertus Taku Inohara Nobuhiro Ikemura Takehiro Kimura Kenneth Mahaffey Kojiro Tanimoto Masahiro Suzuki Makoto Akaishi Hideo Mitamura Seiji Takatsuki |
| author_facet | Iwao Nakamura Ikuko Ueda Keiichi Fukuda Shun Kohsaka John A Spertus Taku Inohara Nobuhiro Ikemura Takehiro Kimura Kenneth Mahaffey Kojiro Tanimoto Masahiro Suzuki Makoto Akaishi Hideo Mitamura Seiji Takatsuki |
| author_sort | Iwao Nakamura |
| collection | DOAJ |
| description | Purpose Besides the high rates of morbidity and mortality, atrial fibrillation (AF) is also associated with impairment of quality-of-life (QOL). However, reports covering non-selected AF population within Asian countries remain scarce. The objective of the Keio interhospital Cardiovascular Studies-atrial fibrillation (KiCS-AF) registry is to clarify the baseline and QOL profiles of the AF patients at the time of initial referral to identify areas for improvement and country-specific gaps.Participants The KiCS-AF registry is a multicentre, prospective cohort study designed to specifically recruit AF patients newly referred to the 11 network hospitals within the Kanto area of Japan. The registry completed its enrolment in June 2018. All patients were requested to answer the Atrial Fibrillation Effect on Quality-of-Life (AFEQT) questionnaire both at baseline and 1 year, with planned clinical follow-up for 5 years. The registry also assessed individual treatment strategies including rate and rhythm control, stroke prophylaxis, and their impacts on patient-reported QOL.Findings to date As of December 2016, 2464 AF patients were registered; their mean age was 67.1 years (SD, 11.7), majority (69.7%; n=1717) were men and 49.2% presented with paroxysmal AF. The mean CHA2DS2-VASc (cardiac failure or dysfunction, hypertension, age ≥75 years, diabetes, stroke including vascular disease, age 65-74 years, and sex category [female]) score was 2.3 (SD, 1.6) and oral anticoagulant therapy was used for 88.6% of patients with CHA2DS2-VASc scores ≥2. The median AFEQT-overall summary score was 79.1 (IQR, 66.6–89.1). Roughly 50% had significantly impaired QOL (ie, AFEQT <80) at baseline. Currently, 2307 eligible patients (93.6%) have completed the 1-year follow-up, of which 2072 patients (89.8%) answered the second AFEQT questionnaire.Future plans The KiCS-AF allowed for extensive investigation of AF-related QOL in a non-selected population with long-term follow-up using a rigorously validated QOL assessment tool. Almost half of patients had impaired QOL at baseline. Further investigations aimed at providing care and improving patient-reported QOL are required. |
| format | Article |
| id | doaj-art-d2e54fd3b36a43bcb71975b030382f0a |
| institution | DOAJ |
| issn | 2044-6055 |
| language | English |
| publishDate | 2019-12-01 |
| publisher | BMJ Publishing Group |
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| spelling | doaj-art-d2e54fd3b36a43bcb71975b030382f0a2025-08-20T02:51:30ZengBMJ Publishing GroupBMJ Open2044-60552019-12-0191210.1136/bmjopen-2019-032746Cohort profile: patient characteristics and quality-of-life measurements for newly-referred patients with atrial fibrillation—Keio interhospital Cardiovascular Studies-atrial fibrillation (KiCS-AF)Iwao Nakamura0Ikuko Ueda1Keiichi Fukuda2Shun Kohsaka3John A Spertus4Taku Inohara5Nobuhiro Ikemura6Takehiro Kimura7Kenneth Mahaffey8Kojiro Tanimoto9Masahiro Suzuki10Makoto Akaishi11Hideo Mitamura12Seiji Takatsuki13Department of Cardiology, Hino Shiritsu Byoin, Hino, Tokyo, JapanDepartment of Cardiology, Keio University School of Medicine, Shinjuku-ku, Tokyo, JapanDepartment of Cardiology, Keio University School of Medicine, Tokyo, JapanDepartment of Cardiology, Keio University School of Medicine, Shinjuku-ku, JapanCardiovascular Research, Department of Biomedical and Health Informatics, Saint Luke`s Mid America Heart Institute, Kansas City, Missouri, USA1 Keio University School of Medicine Graduate School of Medicine, Shinjuku-ku, JapanDepartment of Cardiology, Keio University School of Medicine, Shinjuku-ku, Tokyo, JapanDepartment of Cardiology, Keio University School of Medicine, Tokyo, JapanStanford Center for Clinical Research, Stanford University School of Medicine, Stanford, California, USADeparatment of Cardiology, National Hospital Organisation Tokyo Medical Center, Meguro-ku, Tokyo, JapanMicrobiology, Fujita Health University Hospital, Toyoake, Aichi, JapanDepartment of Cardiology, Tokai University Tokyo Hospital, Shibuya-ku, Tokyo, JapanDepartment of Cardiology, Tachikawa Hospital, Tachikawa, Tokyo, JapanDepartment of Cardiology, Keio University School of Medicine, Tokyo, JapanPurpose Besides the high rates of morbidity and mortality, atrial fibrillation (AF) is also associated with impairment of quality-of-life (QOL). However, reports covering non-selected AF population within Asian countries remain scarce. The objective of the Keio interhospital Cardiovascular Studies-atrial fibrillation (KiCS-AF) registry is to clarify the baseline and QOL profiles of the AF patients at the time of initial referral to identify areas for improvement and country-specific gaps.Participants The KiCS-AF registry is a multicentre, prospective cohort study designed to specifically recruit AF patients newly referred to the 11 network hospitals within the Kanto area of Japan. The registry completed its enrolment in June 2018. All patients were requested to answer the Atrial Fibrillation Effect on Quality-of-Life (AFEQT) questionnaire both at baseline and 1 year, with planned clinical follow-up for 5 years. The registry also assessed individual treatment strategies including rate and rhythm control, stroke prophylaxis, and their impacts on patient-reported QOL.Findings to date As of December 2016, 2464 AF patients were registered; their mean age was 67.1 years (SD, 11.7), majority (69.7%; n=1717) were men and 49.2% presented with paroxysmal AF. The mean CHA2DS2-VASc (cardiac failure or dysfunction, hypertension, age ≥75 years, diabetes, stroke including vascular disease, age 65-74 years, and sex category [female]) score was 2.3 (SD, 1.6) and oral anticoagulant therapy was used for 88.6% of patients with CHA2DS2-VASc scores ≥2. The median AFEQT-overall summary score was 79.1 (IQR, 66.6–89.1). Roughly 50% had significantly impaired QOL (ie, AFEQT <80) at baseline. Currently, 2307 eligible patients (93.6%) have completed the 1-year follow-up, of which 2072 patients (89.8%) answered the second AFEQT questionnaire.Future plans The KiCS-AF allowed for extensive investigation of AF-related QOL in a non-selected population with long-term follow-up using a rigorously validated QOL assessment tool. Almost half of patients had impaired QOL at baseline. Further investigations aimed at providing care and improving patient-reported QOL are required.https://bmjopen.bmj.com/content/9/12/e032746.full |
| spellingShingle | Iwao Nakamura Ikuko Ueda Keiichi Fukuda Shun Kohsaka John A Spertus Taku Inohara Nobuhiro Ikemura Takehiro Kimura Kenneth Mahaffey Kojiro Tanimoto Masahiro Suzuki Makoto Akaishi Hideo Mitamura Seiji Takatsuki Cohort profile: patient characteristics and quality-of-life measurements for newly-referred patients with atrial fibrillation—Keio interhospital Cardiovascular Studies-atrial fibrillation (KiCS-AF) BMJ Open |
| title | Cohort profile: patient characteristics and quality-of-life measurements for newly-referred patients with atrial fibrillation—Keio interhospital Cardiovascular Studies-atrial fibrillation (KiCS-AF) |
| title_full | Cohort profile: patient characteristics and quality-of-life measurements for newly-referred patients with atrial fibrillation—Keio interhospital Cardiovascular Studies-atrial fibrillation (KiCS-AF) |
| title_fullStr | Cohort profile: patient characteristics and quality-of-life measurements for newly-referred patients with atrial fibrillation—Keio interhospital Cardiovascular Studies-atrial fibrillation (KiCS-AF) |
| title_full_unstemmed | Cohort profile: patient characteristics and quality-of-life measurements for newly-referred patients with atrial fibrillation—Keio interhospital Cardiovascular Studies-atrial fibrillation (KiCS-AF) |
| title_short | Cohort profile: patient characteristics and quality-of-life measurements for newly-referred patients with atrial fibrillation—Keio interhospital Cardiovascular Studies-atrial fibrillation (KiCS-AF) |
| title_sort | cohort profile patient characteristics and quality of life measurements for newly referred patients with atrial fibrillation keio interhospital cardiovascular studies atrial fibrillation kics af |
| url | https://bmjopen.bmj.com/content/9/12/e032746.full |
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