Exploring heart failure prevalence and dimensions: A comprehensive NT‐proBNP study in high‐risk primary care patients
Abstract Introduction Early detection of heart failure (HF), particularly in asymptomatic individuals, is essential for timely intervention. This study aimed to determine the prevalence of HF among high‐risk individuals in primary care using N‐terminal probrain natriuretic peptide (NT‐proBNP) screen...
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| Format: | Article |
| Language: | English |
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Wiley
2025-08-01
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| Series: | ESC Heart Failure |
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| Online Access: | https://doi.org/10.1002/ehf2.15290 |
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| author | Ahmet Celik Emrah Yesil Unal Kılıç Gizem Akcay Ozyurt Selman Aytimur Mustafa Demir Huseyin Naci Eker Ayse Siddika Col Cemil Ilker Altiparmak Mustafa Ergen Selen Bozkaya Ismail Sefa Okyay Ibrahim Ethem Kerem Kiristin Marina Arap Melike Yirtar Deniz Korkmaz Ali Kırdağ Ismail Turkay Ozcan |
| author_facet | Ahmet Celik Emrah Yesil Unal Kılıç Gizem Akcay Ozyurt Selman Aytimur Mustafa Demir Huseyin Naci Eker Ayse Siddika Col Cemil Ilker Altiparmak Mustafa Ergen Selen Bozkaya Ismail Sefa Okyay Ibrahim Ethem Kerem Kiristin Marina Arap Melike Yirtar Deniz Korkmaz Ali Kırdağ Ismail Turkay Ozcan |
| author_sort | Ahmet Celik |
| collection | DOAJ |
| description | Abstract Introduction Early detection of heart failure (HF), particularly in asymptomatic individuals, is essential for timely intervention. This study aimed to determine the prevalence of HF among high‐risk individuals in primary care using N‐terminal probrain natriuretic peptide (NT‐proBNP) screening. Methods A prospective cohort of 874 participants aged ≥40 years with at least one HF risk factor but no prior HF diagnosis was analysed. NT‐proBNP levels were measured, and all participants underwent comprehensive cardiac evaluations, including laboratory tests, electrocardiography and echocardiography. Results The mean age of the cohort was 62.5 ± 9.1 years, and 51.9% were female. Based on ACC/AHA HF staging, 69.1% of participants were classified as Stage A, 21.9% as Stage B and 9.0% as Stage C. Elevated NT‐proBNP levels were detected in 84.8% of Stage B and 100% of Stage C patients. Among Stage C patients, 92.4% had HF with preserved ejection fraction (HFpEF). NT‐proBNP levels correlated positively with left atrial volume index (r = 0.273, P < 0.001), left ventricular mass index (r = 0.207, P < 0.001), E/e′ ratio (r = 0.182, P < 0.001) and estimated systolic pulmonary artery pressure (r = 0.124, P < 0.001), while showing a negative correlation with estimated glomerular filtration rate (r = −0.222, P < 0.001). Conclusions A significant proportion of high‐risk individuals in primary care had undiagnosed HF, particularly Stage B (pre‐HF) and early symptomatic Stage C HF. The predominance of HFpEF highlights the need for targeted management. NT‐proBNP screening is a valuable tool for early identification and risk stratification, especially for detecting Stage B HF, where it serves as an effective standalone method in the absence of imaging. |
| format | Article |
| id | doaj-art-d2df4294f2ef43c995dfe461affe8066 |
| institution | Kabale University |
| issn | 2055-5822 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | ESC Heart Failure |
| spelling | doaj-art-d2df4294f2ef43c995dfe461affe80662025-08-20T03:51:44ZengWileyESC Heart Failure2055-58222025-08-011242834284210.1002/ehf2.15290Exploring heart failure prevalence and dimensions: A comprehensive NT‐proBNP study in high‐risk primary care patientsAhmet Celik0Emrah Yesil1Unal Kılıç2Gizem Akcay Ozyurt3Selman Aytimur4Mustafa Demir5Huseyin Naci Eker6Ayse Siddika Col7Cemil Ilker Altiparmak8Mustafa Ergen9Selen Bozkaya10Ismail Sefa Okyay11Ibrahim Ethem Kerem12Kiristin Marina Arap13Melike Yirtar14Deniz Korkmaz15Ali Kırdağ16Ismail Turkay Ozcan17Department of Cardiology, Faculty of Medicine Mersin University Mersin TurkeyDepartment of Cardiology, Faculty of Medicine Mersin University Mersin TurkeyMersin Ticaret Borsasi Primary Health Care Center Mersin TurkeyDepartment of Cardiology, Faculty of Medicine Mersin University Mersin TurkeyDepartment of Cardiology, Faculty of Medicine Mersin University Mersin TurkeyDepartment of Cardiology, Faculty of Medicine Mersin University Mersin TurkeyMersin Central Primary Health Care Center Mersin TurkeyMersin Mimar Sinan Primary Health Care Center Mersin TurkeyMersin Ticaret Borsasi Primary Health Care Center Mersin TurkeyMersin Toroslar Osmaniye Primary Health Care Center Mersin TurkeyMersin Gazi Primary Health Care Center Mersin TurkeyMersin Mezitli Sahil Primary Health Care Center Mersin TurkeyMersin Ticaret Borsasi Primary Health Care Center Mersin TurkeyMersin Mimar Sinan Primary Health Care Center Mersin TurkeyMersin Osman Gazi Primary Health Care Center Mersin TurkeyMersin Ciftlikkoy Primary Health Care Center Mersin TurkeyMersin Selahattin Yanpar Primary Health Care Center Mersin TurkeyDepartment of Cardiology, Faculty of Medicine Mersin University Mersin TurkeyAbstract Introduction Early detection of heart failure (HF), particularly in asymptomatic individuals, is essential for timely intervention. This study aimed to determine the prevalence of HF among high‐risk individuals in primary care using N‐terminal probrain natriuretic peptide (NT‐proBNP) screening. Methods A prospective cohort of 874 participants aged ≥40 years with at least one HF risk factor but no prior HF diagnosis was analysed. NT‐proBNP levels were measured, and all participants underwent comprehensive cardiac evaluations, including laboratory tests, electrocardiography and echocardiography. Results The mean age of the cohort was 62.5 ± 9.1 years, and 51.9% were female. Based on ACC/AHA HF staging, 69.1% of participants were classified as Stage A, 21.9% as Stage B and 9.0% as Stage C. Elevated NT‐proBNP levels were detected in 84.8% of Stage B and 100% of Stage C patients. Among Stage C patients, 92.4% had HF with preserved ejection fraction (HFpEF). NT‐proBNP levels correlated positively with left atrial volume index (r = 0.273, P < 0.001), left ventricular mass index (r = 0.207, P < 0.001), E/e′ ratio (r = 0.182, P < 0.001) and estimated systolic pulmonary artery pressure (r = 0.124, P < 0.001), while showing a negative correlation with estimated glomerular filtration rate (r = −0.222, P < 0.001). Conclusions A significant proportion of high‐risk individuals in primary care had undiagnosed HF, particularly Stage B (pre‐HF) and early symptomatic Stage C HF. The predominance of HFpEF highlights the need for targeted management. NT‐proBNP screening is a valuable tool for early identification and risk stratification, especially for detecting Stage B HF, where it serves as an effective standalone method in the absence of imaging.https://doi.org/10.1002/ehf2.15290NT‐proBNPHFpEFprimary careStage AStage BStage C |
| spellingShingle | Ahmet Celik Emrah Yesil Unal Kılıç Gizem Akcay Ozyurt Selman Aytimur Mustafa Demir Huseyin Naci Eker Ayse Siddika Col Cemil Ilker Altiparmak Mustafa Ergen Selen Bozkaya Ismail Sefa Okyay Ibrahim Ethem Kerem Kiristin Marina Arap Melike Yirtar Deniz Korkmaz Ali Kırdağ Ismail Turkay Ozcan Exploring heart failure prevalence and dimensions: A comprehensive NT‐proBNP study in high‐risk primary care patients ESC Heart Failure NT‐proBNP HFpEF primary care Stage A Stage B Stage C |
| title | Exploring heart failure prevalence and dimensions: A comprehensive NT‐proBNP study in high‐risk primary care patients |
| title_full | Exploring heart failure prevalence and dimensions: A comprehensive NT‐proBNP study in high‐risk primary care patients |
| title_fullStr | Exploring heart failure prevalence and dimensions: A comprehensive NT‐proBNP study in high‐risk primary care patients |
| title_full_unstemmed | Exploring heart failure prevalence and dimensions: A comprehensive NT‐proBNP study in high‐risk primary care patients |
| title_short | Exploring heart failure prevalence and dimensions: A comprehensive NT‐proBNP study in high‐risk primary care patients |
| title_sort | exploring heart failure prevalence and dimensions a comprehensive nt probnp study in high risk primary care patients |
| topic | NT‐proBNP HFpEF primary care Stage A Stage B Stage C |
| url | https://doi.org/10.1002/ehf2.15290 |
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