Suppression of PINK1 autophosphorylation attenuates pilocarpine-induced seizures and neuronal injury in rats

Suppression of PINK1 autophosphorylation attenuates pilocarpine-induced seizures and neuronal injury in rats

PTEN-induced kinase 1 (PINK1) autophosphorylation triggers the PINK1/Parkin pathway, which is the main mitophagic pathway in the mammalian nervous system. In the present study, we aimed to mechanistically explore the role of PINK1 in pilocarpine-induced status epilepticus (SE) in Sprague-Dawley rats...

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Bibliographic Details
Main Authors: Yujie Zhai, Yi Yuan, Yaru Cui, Xiaoqian Wang, Hua Zhou, Qian Teng, Hongjin Wang, Bohan Sun, Hongliu Sun, Jianhua Tang
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Brain Research Bulletin
Subjects:
PTEN-induced kinase 1
Status epilepticus
Mitophagy
Mitochondrial oxidative stress
Neuronal injury
Online Access:http://www.sciencedirect.com/science/article/pii/S036192302400251X
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